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Autor: Shoji Fukushima
ISBN-13: 9780128018033
Einband: EPUB
Seiten: 224
Sprache: Englisch
eBook Typ: Adobe Digital Editions
eBook Format: EPUB
Kopierschutz: Adobe DRM [Hard-DRM]
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Thresholds of Genotoxic Carcinogens

From Mechanisms to Regulation
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Thresholds of Genotoxic Carcinogens: From Mechanisms to Regulation brings together current opinion and research activities from Japan, the US, and Europe on the subject of genotoxic thresholds. In regulation, it is an adage that genotoxic carcinogens have no thresholds for action, and that they impose cancer risk on humans even at very low levels. This policy is frequently called into question as humans possess a number of defense mechanisms including detoxication, DNA repair, and apoptosis, meaning there is a threshold at which these genotoxic carcinogens take action. The book examines these potential thresholds, describing the potential cancer risks of daily low-level exposure, the mechanisms involved (such as DNA repair, detoxication, translesion DNA synthesis), chemical and statistical methods of analysis, and the ways in which these may be utilized to inform policy. Thresholds of Genotoxic Carcinogens: From Mechanisms to Regulation is an essential reference for any professional researchers in genetic toxicology and those involved in toxicological regulation.Unites an international team of experts to provide a balanced overview of the current opinion on thresholds of genotoxic carcinogensProvides all the information readers need to determine a safe threshold for potential genotoxic carcinogensIncludes information on the mechanisms of genotoxic carcinogens and how these can inform regulationServes as an essential reference for any professional researchers in genetic toxicology and those involved in toxicological regulation
1
Thresholds of Genotoxic Carcinogens: From Mechanisms to Regulation brings together current opinion and research activities from Japan, the US, and Europe on the subject of genotoxic thresholds. In regulation, it is an adage that genotoxic carcinogens have no thresholds for action, and that they impose cancer risk on humans even at very low levels. This policy is frequently called into question as humans possess a number of defense mechanisms including detoxication, DNA repair, and apoptosis, meaning there is a threshold at which these genotoxic carcinogens take action. The book examines these potential thresholds, describing the potential cancer risks of daily low-level exposure, the mechanisms involved (such as DNA repair, detoxication, translesion DNA synthesis), chemical and statistical methods of analysis, and the ways in which these may be utilized to inform policy. Thresholds of Genotoxic Carcinogens: From Mechanisms to Regulation is an essential reference for any professional researchers in genetic toxicology and those involved in toxicological regulation.Unites an international team of experts to provide a balanced overview of the current opinion on thresholds of genotoxic carcinogensProvides all the information readers need to determine a safe threshold for potential genotoxic carcinogensIncludes information on the mechanisms of genotoxic carcinogens and how these can inform regulationServes as an essential reference for any professional researchers in genetic toxicology and those involved in toxicological regulation

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Autor: Shoji Fukushima
ISBN-13 :: 9780128018033
ISBN: 0128018038
Verlag: Elsevier Science
Seiten: 224
Sprache: Englisch
Sonstiges: Ebook, Maximale Downloadanzahl: 3