1. Molecular Modeling and Chemoinformatics to Advance the Development of Modulators of Epigenetic Targets: A Focus on DNA Methyltransferases Fernando D. Prieto-Martínez, Andrea Peña-Castillo, Oscar Méndez-Lucio, Eli Fernández-De Gortari and José L. Medina-Franco 2. Recent Advances in Computational Models for the Study Protein-Peptide Interactions Denise Kilburg and Emilio Gallicchio 3. Structural Plasticity in Globins: Role of Protein Dynamics in Defining Ligand Migration Pathways C. Estarellas, L. Capece, C. Seira, A. Bidon-Chanal, D. A. Estrin and F. J. Luque 4. Dynamic Reorganization and Enzymatic Remodeling of Type IV Collagen at Cell- Biomaterial Interface Nuno Miranda Coelho, Virginia Llopis-Hernández, Manuel Salmerón-Sánchez and George Altankov 5. Cytochromes P450: History, Classes, Catalytic Mechanism and Industrial Application Darren J. Cook, James D. Cook, Ken Cook, Gary W. Black and Simon J. Charnock 6. Understanding the Multifaceted Role of Human Down Syndrome Kinase DYRK1A Laura J. Kay, Tora K. Smulders-Srinivasan and Meera Soundararajan

Insights into Enzyme Mechanisms and Functions from Experimental and Computational Methods is the latest volume in the popular Advances in Protein Chemistry and Structural Biology series, an essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins, with each thematically organized volume guest edited by leading experts in a broad range of protein-related topics.