The Tew laboratory maintains an interest in using redox pathways as a platform to develop therapeutic strategies through drug discovery/development and biomarker identification. We interrogate how reactive oxygen and nitrogen species (ROS/RNS) impact cancer cells and develop novel drugs that impact on glutathione based pathways. Our research efforts have been integral to studies that have identified glutathione S-transferases (GST) as important in drug resistance, catalytic detoxification and as arbiters of kinase-mediated cell signaling events. In addition, we have been instrumental in defining how GSTP contributes to the process by which cells respond to ROS by selective addition of glutathione to specific protein clusters, so called S-glutathionylation. Each of these research areas has had broad impact on a number of cancer disciplines. Moreover, we have also been seminally involved in the Phase I to III clinical testing of three oncology drugs, Telcyta, Telintra and NOV-002. Other ongoing translational efforts have produced two ongoing clinical trials to measure the effectiveness of serum S-glutathionylated serine proteinase inhibitors as possible biomarkers for exposure to hydrogen peroxide mouthwashes and radiation.

1. The Epidemiology of Selenium and Human CancerMarco Vinceti, Tommaso Filippini, Silvia Cilloni, and Catherine M. Crespi2. Selenoproteins in Tumorigenesis and Cancer ProgressionSarah P. Short and Christopher S. Williams3. Selenoproteins and MetastasisMichael P. Marciel and Peter R. Hoffmann4. Selenium-Dependent Glutathione Peroxidases During Tumor DevelopmentAnna P. Kipp5. Targeting the Selenoprotein Thioredoxin Reductase 1 for Anticancer TherapyElias S.J. Arnér6. The Regulation of Pathways of Inflammation and Resolution in Immune Cells and Cancer Stem Cells by SeleniumBastihalli T. Diwakar, Arvind M. Korwar, Robert F. Paulson, and K. Sandeep Prabhu7. Selenium and Breast Cancer Risk: Focus on Cellular and Molecular MechanismsCamile C. Fontelles and Thomas P. Ong8. Selenium and Epigenetics in Cancer: Focus on DNA MethylationEwa Jablonska and Edyta Reszka 9. Selenium and Cancer Stem CellsGiuseppe Murdolo, Desirée Bartolini, Cristina Tortoioli, Marta Piroddi, Pierangelo Torquato, and Francesco Galli10. elenocompounds in Cancer Therapy: An OverviewDesirée Bartolini, Luca Sancineto, Andreza Fabro de Bem, Kenneth D. Tew, Claudio Santi, Rafael Radi, Pierangelo Toquato, and Francesco Galli

Selenium and Selenoproteins in Cancer, Volume 136, the latest release in the Advances in Cancer Research series, provides invaluable information on the fast-moving field of cancer research. This updated volume includes chapters on The epidemiology of selenium and human cancer, Selenium, epigenetics and cancer, Selenium status and cancer risk, Nutritional aspects of selenium and breast cancer risk: focus on cellular and molecular mechanisms, Selenoproteins in tumorigenesis and cancer progression, Selenoproteins and metastasis, The tumor microenvironment and inflammatory factors, and Selenium-dependent glutathione peroxidases during tumor development.

This new release in the series presents original reviews on research regarding the prevention and treatment of cancer with selenium.