Part I: Hematopoietic Stem Cell Development. 1. The Development of Hematopoietic Cell Transplantation and its Application to Organ Transplantation and Autoimmune Diseases; E.D. Thomas. 2. Hemopoietic Stem Cells - Normal and Abnormal; S. Ikehara. 3. Immunity and Tolerance are Related, and Governed by Antigen Migration and Localization; T.E. Starzl, et al. 4. Genetic Approaches to the Investigation of the Mechanisms of Hematopoietic Progenitor Cell Mobilization into the Blood; A.W. Roberts, et al. 5. Role of Hematopoietic Growth Factors on the Ex-Vivo Expansion of Primitive Cord Blood Stem Cells; M. Aglietta, et al. 6. Thymus-Independent T Cell Differentiation In Vitro; M. Sanchez, et al. 7. Immunogenetics Problems in Cord Blood Transplantation; F. Poli, et al. Part II: Update on Solid Tumor and Bone Marrow Transplantation. 8. High-Dose Chemotherapy for Breast Cancer in Europe: From Fashion to Randomization; G. Rosti, et al. 9. Differential Enhancement of Graft-versus-Host (GVH) and Graft-versus-Leukemia (GVL) Reactions by Interleukin-12 (IL-12); M. Schmitt, et al. 10. De Novo and Secondary AML Cells Differ in Their Kinetic Response to HGF Priming; M.A. Smith, et al. 11. Clinical Factors Contributing to the Pace of Engraftment after Allogeneic and Autologous Stem Cell Transplantation: Multivariate Analysis; G.J. Elfenbein. 12. Clinical Relevance of Bone Marrow Histologic Examination in HIV-Infected Patients; S. Cantoni, et al. 13. Molecular Biology of Childhood Solid Tumors; Promises Maintained and Promises Postponed; C. Dominici, P.Kogner. 14. Molecular Genetics of Wilms Tumor; K. Pritchard-Jones. 15. Genetic Heterogeneity in Ewing Tumors and Neuroblastomas; P.F. Ambros, et al. 16. Mechanisms of Retinoid Inhibition of Cell Proliferation in Neuroblastoma; T. Matsuo, C.J. Thiele. 17. Combination of Carboplatin and Etoposide in the Management of Intraocular Retinoblastoma; M.A. Castello, et al. 18. Hyper-IL-6 (H-IL-6), a Fusion Protein of Soluble IL-6 Receptor (sIL-6R) and Interleukin-6 (IL-6), Acts Synergistic with Thrombopoietin (TPO) and Stem Cell Factor (SCF) in Expanding Megakaryocyte Progenitors from Human CD34++/CD90+ Cell; J. Birkmann, et al. 19. Towards Vaccination with Defined Tumor Antigens? P. van de Bruggen, et al. Part III: Myloproliferative Disorders: Basic and Clinical Update. 20. Classification of Malignant Lymphomas: State of the Art; S.A. Pileri, E. Sabattini. The Pathologic Spectrum of AIDS-Related Non-Hodgkin's Lymphomas; U. Carbone, et al. 22. Genesis and Progression of Gastric Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma; M-Q. Du, P.G. Isaacson. 23. De Novo and Secondary AML Cells Differ in Their Kinetic Response to HGF Priming; M.A. Smith, et al. 24. Molecular Diagnosis of Philadelphia-Positive Leukemias; C. Ha kovec, J. Polák. 25. Molecular Monitoring of Non-Hodgkin's Lymphomas; A. Slavickova, et al. Part IV: Regulation of Hematopoiesis. 26. Differential Expression of IL-3 and GM-CSF Receptor Common Signal Transducing Subunit (&bgr;C) During Normal Hematopoietic Differentiation; U. Testa, et al. 27.

This volume of Molecular Biology of Hematopoiesis is dedicated to many inter national scientists and clinicians for their contribution to the field of Hematology/ Oncology presented at the 11th International Symposium on Molecular Biology of Hematopoiesis, which was held in Bormio, Italy, June 25-29, 1998. The continuous support of the Presidents of the meeting, Professor F. Takaku, President of Jichi University, and E. D. Thomas, Nobel Laureate, was greatly acknowledged, especially Professor Takaku, for his vision and support for development of gene therapy in Japan. New information on BMT for autoimmune disease and organ transplantation was presented at the symposium and is published in this volume. Several new findings on gene therapy/transfer into HSC were presented by E. F. Vanin and A. Nienhuis, K. Humphries, 1. A. Nolta, H. E. Heslop, and M. K. Brenner. Professors S. Asano and K. Tani presented new studies on gene transfer into primates. Among the highlights were the new papers on gene transfer presented by G. Wage maker, N. G. Abraham, and M. Onoderea from R. M. BJaese's group. The use of BMT for organ transplant and autoim mune disease was updated and a representative paper is presented in this volume.