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Small-Animal SPECT Imaging
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HARRISON H. BARRETT received a BS in physics from Virginia Polytechnic Institute, an MS in Physics from MIT, and a PhD in applied physics from Harvard. Dr. Barrett is a professor in the Optical Sciences Center, the Department of Radiology, and the Program in Applied Mathematics and serves as Director of the Center for Gamma-ray Imaging. The holder of twenty-three U.S. patents, he is the recipient of the IEEE Medical Imaging Scientist Award and a Humboldt Prize.
Small-animal SPECT is a relatively new imaging tool that can aid in drug development, drug research, molecular imaging, and imaging science
- Preface -Biomedical Significance of Small-Animal Imaging -Detectors for Small-Animal SPECT I -Detectors for Small-Animal SPECT II -The Animal in Animal Imaging -Objective Assessment of Image Quality -SPECT Imager Design and Data-Acquisition Systems -Computational Algorithms in Small-Animal Imaging -Reconstruction Algorithm with Resolution Deconvolution in a Small-Animal PET Imager -Estimates of Axial and Transaxial Resolution for One-, Two-, and Three-Camera Helical Pinhole SPECT -Pinhole Aperture Design for Small-Animal Imaging -Comparison of CsI(Ti) and Scintillating Plastic in a Multi-Pinhole/CCD-Based Gamma Camera for Small-Animal Low-Energy SPECT -Calibration of Scintillation Cameras and Pinhole SPECT Imaging Systems -Imaging Dopamine Transporters in a Mouse Brain with Single-Pinhole SPECT -A Micro-SPECT/CT System for Imaging of AA-Amyloidosis in Mice -Feasibility of Micro-SPECT/CT Imaging of Atherosclerotic Plaques in a Transgenic Mouse Model -Effect of Respiratory Motion on Plaque Imaging in the Mouse Using Tc-99m Labeled Annexin-V -Calibration and Performance of the Fully Engineered YAP-(S)PET Scanner for Small Rodents -A Small-Animal SPECT Imaging System Utilizing Position Tracking of Unanesthetized Mice -A Multidetector High-Resolution SPECT/CT Scanner with Continuous Scanning Capability -High-Resolution Multi-Pinhole Imaging Using Silicon Detectors -Development and Characterization of a High-Resolution MicroSPECT System -High-Resolution Radionuclide Imaging Using Focusing Gamma-Ray Optics -SPECT/Micro-CT Imaging of Bronchial Angiogenesis in a Rat -Projection and Pinhole-Based Data Acquisition for Small-Animal SPECT Using Storage Phosphor Technology -Index
Small-Animal SPECT Imaging is an edited work derived from the first workshop on Small-Animal SPECT Imaging held January 14-16, 2004 at the University of Arizona, Tucson, AZ, USA. The overall goal of the meeting and therefore this volume is to promote information exchange and collaboration between the research groups developing systems for small-animal applications. Topics include the biomedical significance of small-animal imaging, an overview of detector technologies including scintillation cameras and semi-conductor arrays, imager design and data acquisition systems, animal handling and anesthesia issues, objective assessment of image quality, and system modeling and reconstruction algorithms.