Beschreibung:
Inflammatory Bowel Disease: From Bench to Bedside is a detailed and comprehensive story of the local and systemic pathophysiology of intestinal inflammation including management strategies. Research advances and current concepts of etiopathogenesis in the context of what is already known of the clinicopathologic features of these disorders are explored. This volume blends recent advances in the basic and clinical sciences as they relate to inflammatory bowel disease and emphasizes the effectiveness of a team approach of basic scientists and clinician investigators in this field.
Inflammatory Bowel Disease: From Bench to Bedside is a detailed and comprehensive story of the local and systemic pathophysiology of intestinal inflammation including management strategies. Research advances and current concepts of etiopathogenesis in the context of what is already known of the clinicopathologic features of these disorders is explored. This volume blends recent advances in the basic and clinical sciences as they relate to inflammatory bowel disease and emphasizes the effectiveness of a team approach of basic scientists and clinician investigators in this field.
Preface. Section 1: The Laboratory Bench. 1. Introduction: Inflammatory Bowel Diseases: From Bench to Bedside; S. R. Targan, F. Shanahan, L. C. Karp. 2. The Changing Faces of Crohn's Disease and Ulcerative Colitis; A. Ekbom. 3. Genetics of Inflammatory Bowel Disease; J.I. Rotter, H. Yang. 4. Experimental Mouse Models of Inflammatory Bowel Disease: New Insights into Pathogenic Mechanisms; C.O. Elson. 5. The Normal Intestinal Mucosa - A State of `Controlled' Inflammation; C. Fiochi. 6. The Lymphocyte/ Epithelial/ Bacterial Interface; R. Hershberg and R. Blumberg. 7. The Mucosal Inflammatory Response I: Cytokines and Chemokines; F. Cominelli. 8. Role of the Microcirulation in Chronic Gut Inflammation; M. B. Grisham, F. S. Laroux and D. N. Granger. 9. Remission, Relapse, Intestinal Healing and Repair; M. N. Göke, D. Podolsky. 10. Antibodies in the Exploration of Inflammatory Bowel Disease Pathogenesis and Disease Stratification; J. Braun, O. Cohavy and M. Eggena. 11. Pathophysiology of Inflammatory Bowel Disease: The Effect of Inflammation on Intestinal Function; S. Collins and K. Croitoru. 12. Systemic Consequences of Intestinal Inflammation; K. A. Papodakis and M.T. Abreu. Section II: The Bedside. 13. Understanding Symptoms and Signs in Inflammatory Bowel Diseases; C. C. Cronin and F. Shanahan. 14. Clinical Course and Complications of Ulcerative Colitis and Ulcerative Proctitis; R. Panaccione and L. Sutherland. 15. Clinical Features and Complications of Crohn's Disease; W. Tremaine. 16. Mechanisms of Systemic Inflammation Associated with Intestinal Injury; R. B. Sartor and S. N. Lichtman. 17. Pathology of Inflammatory Bowel Diseases: A Critical Appraisal in Diagnosis and Management; G. Cortina and K. Lewin. 18. An Endoscopic and Histologic Perspective of Diagnosis: When, Where and What to Do; C. Bernstein and R. H. Riddell. 19. Radiologic (Radiographic) and Imaging Features of Ulcerative Colitis and Crohn's Disease; E. Fitzgerald. 20. New Diagnostic Approaches inInflammatory Bowel Disease; L. Kam and E. Vasiliauskas. 21. Differential Diagnosis of Colitis; S. C. Eng and C. M. Surawicz. 22. 'Disease Management' in Chronic Medical Conditions; D. H. Alpers. 23. Pharmacoeconomics and Inflammatory Bowel Disease; B. Feagan. 24. Measuring Quality of Life in Inflammatory Bowel Disease; E.J. Irvine. 25-49 Additional Chapters. Section III: Back to the Laboratory Bench. 50. Epilogue; S.R. Targan, L. C. Karp and F. Shanahan.
Inflammatory Bowel Disease: From Bench to Bedside is a detailed and comprehensive story of the local and systemic pathophysiology of intestinal inflammation including management strategies. Research advances and current concepts of etiopathogenesis in the context of what is already known of the clinicopathologic features of these disorders are explored. This volume blends recent advances in the basic and clinical sciences as they relate to inflammatory bowel disease and emphasizes the effectiveness of a team approach of basic scientists and clinician investigators in this field.
