Neuropathology and Basic Neuroscience

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1. Nervous System Structure and Function.- Componentsr.- Central nervous system subdivisions.- Spinal cord.- Brain stem.- Cerebellum.- Diencephalon.- Basal ganglia.- Corticoid and allocortex.- Cerebral cortex.- Blood supply.- Neuron.- Axon.- Dendrite.- Neuronal physiology.- Acetylcholine.- Dopamine.- Norepinephrine.- Serotonin.- ?-Aminobutyric acid (GABA).- Glycine.- Glutamate.- Opioids.- Neuroglia.- Astrocyte.- Oligodendrocyte.- Ependymal cell.- Microglial cell.- Endothelial cells.- Pia-arachnoid.- 2. Principles of Cerebral Localization Syndromes.- Hemisyndromes.- Behavioral syndromes.- Frontal lobe syndromes.- Parietal lobe syndromes.- Temporal lobe syndromes.- Occipital lobe syndromes.- Basal ganglia syndromes.- Thalamic syndromes.- Hypothalamic syndromes.- Brain stem syndromes.- Cerebellar syndromes.- Spinal cord syndromes.- Peripheral nervous system syndromes.- Visual disturbances.- Vertigo, dizziness, unsteadiness.- Unilateral facial paralysis.- Gait disturbances.- Epilepsy and seizure disorder.- 3. Brain Edema and Mass Effect Edema.- Intracranial fluid dynamics.- Brain herniation.- 4. Pathology of Cerebrovascular Disease Stroke.- Hypoxia, ischemia, infarction.- Hypoxic/ischemic encephalopathy.- Transient ischemic attacks (TIA' s).- Fibromuscular dysplasia.- Moyamoya disease.- Cerebral amyloid angiopathy (congophilic angiopathy).- Arteritis (vasculitis).- Hypertensive cerebrovascular disease.- Intracranial vascular aneurysms.- Arteriovenous malformations.- Subependymal and intraventricular hemorrhage.- 5. Pathology of Central Nervous System Infections.- Sites of CNS infections.- Blood-brain barrier.- Meningitis.- Focal suppurative infections.- Fungal and parasitic CNS infections.- Neurosyphilis.- Lyme disease.- Acquired immunodeficiency syndrome (AIDS).-Arbovirus encephalitis.- Herpesvirus encephalitis.- Poliomyelitis.- Rabies.- Subacute sclerosing panencephalitis (SSPE).- Transmissible spongiform encephalopathies.- 6. Neurodegenerative Diseases and Dementia Definitions.- Alzheimer' s disease.- Pick' s disease (lobar atrophy).- Parkinsonism (Parkinson' s syndrome).- Huntington' s disease (Huntington' s chorea).- Spinocerebellar degeneration.- 7. Nervous System Tumors Pathophysiology of symptoms.- Diagnosis of brain tumor.- Glioma.- Primitive neuroectodermal tumor (PNET).- Peripheral neuroblastoma.- Pheochromocytoma.- Craniopharyngioma.- Colloid cyst of third ventricle.- Meningioma.- Schwannoma (neurilemmoma).- Neurofibroma.- Hemangioblastoma of cerebellum (Lindau' s tumur).- Chordoma.- Primary central nervous system lymphoma.- Metastatic tumors.- 8. Pathology of Craniocerebral Trauma Craniocerebral trauma.- Missile injuries.- Closed head injury.- Delayed complications of head injury.- 9. Peripheral Nerve and Muscle Pathology Anatomy and physiology.- Electrophysiologic studies.- Pathology.- 10. Pathology of Toxic and Nutritional Diseases Central pontine myelinolysis.- Marchiafava-Bignami disease.- Methanol (methyl alcohol; wood alcohol) poisoning.- Ethylene glycol poisoning.- Lead poisoning.- Arsenic poisoning.- Mercury poisoning (organic or inorganic mercury).- Thallium poisoning.- Carbon monoxide poisoning.- Wernicke-Korsakoff syndrome.- Alcoholic cerebellar degeneration.- Vitamin E (?-tocopherol) deficiency.- Vitamin B deficiency.- Hypoglycemic encephalopathy.- Hepatic encephalopathy.- Uremic neuropathy.- Kernicterus.- Radiation effects.- 11. Pathology of Neurometabolic Disorders Gaucher' s disease.- Niemann-Pick disease.- GM2-gangliosidosis.- Fabry' s disease.- Ceroid lipofuscinoses.- Metachromaticleukodystrophy.- Krabbe' s disease (globoid cell leukodystrophy).- Peroxisomal disorders.- Mucopolysaccharidoses.- Aminoacid disorders.- Transferase-deficient galactosemia.- Glycogen storage disorders.- Wilson' s disease (hepatolenticular degeneration).- Alexander' s disease.- Canavan' s disease.- Leigh' s disease.- Lesch-Nyhan disease.- Porphyria.- 12. Pathology of Demyelinating Disorders Multiple sclerosis (MS).- Acute disseminated encephalomyelitis.- Acute necrotizing hemorrhagic encephalomyelitis.- Guillain-Barré syndrome.- 13. Nervous System Malformations Definitions.- Neural tube defects (dysraphic disorders).- Trisomy 21 syndrome (Down' s syndrome).- Hydrocephalus (hydrocephaly).- Anomalies of neuronal migration.- Hydranencephaly.- Porencephaly.- Multicystic encephalopathy.- Holoprosencephaly.- Encephalocele.- Agenesis of the corpus callosum.- Arrhinencephaly.- 14. Spinal Cord Pathology Vascular disorders.- Inflammatory conditions.- Spinal trauma.- Degeneration of intervertebral disc.- Rheumatoid arthritis.- Ossification of posterior longitudinal ligament.- Syringomyelia.- Neoplasms.- Spinal cord anomalies.- 15. Pineal Gland Pathology Anatomy and physiology.- Innervation of pineal gland.- Circumventricular secretory organs.- Pineal neoplasm.- Germ cell tumors.- 16. Pituitary Gland Pathology Pituitary gland location.- Embryonic derivation.- Vascular supply.- Cellular architecture of adenohypophysis.- Neurohypophyseal hormones.- Hypothalamic hypophysiotrophic hormones.- Adenohypophyseal hormones.- Adrenocorticotropic hormone (ACTH).- Thyrotropin.- Gonadotropins.- Human growth hormone.- Prolactin.- Pituitary adenoma.- 17. Eye Pathology Orbit.- Eyelids.- Cornea, sclera, and conjunctiva.- Anterior and posterior chambers.- Uveal tract.- Lens.- Vitreous.-Retina.- Vascular disease.- Pigmentary retinopathy.- 18. Ear Pathology External ear.- Middle ear.- Inner ear.- Cochlea.- Physiologic studies.- Otitis media.- Otosclerosis.- Ménière' s disease.- Self-assessment examination #1.- Self-assessment examination #2.- Answers to self-assessment examinations.
This new addition to the Oklahoma Notes series is written specifically to fit with modern neuroscience courses, which integrate basic science (anatomy, biochemistry, and physiology of the nervous system) with clinical science (how diseases of the nervous system present in the clinic). Each Oklahoma Notes book presents the core information of one segment of the medical school curriculum. Written by some of the most effective medical educators in the country, and now thoroughly updated and revised, the Oklahoma Notes feature: Concise text presented in outline format for rapid review; contents oriented to promote Boards success; self-assessment questions geared to the current format of the USMLE exam; more tables and figures designed to facilitate self-assessment and review; and low-cost, complete coverage of all subjects taught in the first two years of medical school.

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