About the Series... Metal Ions in Life Sciences links coordination chemistry and biochemistry in their widest sense and thus increases our understanding of the relationship between the chemistry of metals and life processes. The series reflects the interdisciplinary nature of Biological Inorganic Chemistry and coordinates the efforts of scientists in fields like biochemistry, inorganic chemistry, coordination chemistry, molecular and structural biology, enzymology, environmental chemistry, physiology, toxicology, biophysics, pharmacy, and medicine. Consequently, the volumes are an essential source for researchers active in these and related fields as well as teachers preparing courses, e.g., in Bioinorganic Chemistry. About this Book... Volume 1, devoted solely to the vital research area concerning the role of metal ions in neurodegenerative diseases, offers in 15 stimulating chapters an authoritative and timely view of this fascinating subject. Written by 41 internationally recognized experts, Neurodegenerative Diseases and Metal Ions highlights, supported by 130 illustrations, the recent progress made in understanding the role metal ions play in diseases like transmissible spongiform encephalopathies (Creutzfeldt-Jakob and related diseases), Alzheimer's, Parkinson's, Huntington's, Wilson's and Menkes' diseases, as well as in familial amyotrophic lateral sclerosis and others. The interplay between metal ions, catecholamines and the formation of reactive oxygen species resulting in oxidative stress is considered, as is the metalloneurochemistry of zinc and the neurotoxicity of aluminum, cadmium, lead, and mercury. The need for novel drugs which manipulate metal-centered neuropathology is emphasized.

About the Series...Metal Ions in Life Sciences links coordinationchemistry and biochemistry in their widest sense and thus increasesour understanding of the relationship between the chemistry ofmetals and life processes. The series reflects theinterdisciplinary nature of Biological Inorganic Chemistryand coordinates the efforts of scientists in fields likebiochemistry, inorganic chemistry, coordination chemistrymolecular and structural biology, enzymology, environmentalchemistry, physiology, toxicology, biophysics, pharmacy, andmedicine. Consequently, the volumes are an essential source forresearchers active in these and related fields as well as teacherspreparing courses, e.g., in Bioinorganic Chemistry.About this Book...Volume 1, devoted solely to the vital research areaconcerning the role of metal ions in neurodegenerative diseasesoffers in 15 stimulating chapters an authoritative and timely viewof this fascinating subject.Written by 41 internationally recognized expertsNeurodegenerative Diseases and Metal Ions highlightssupported by 130 illustrations, the recent progress made inunderstanding the role metal ions play in diseases liketransmissible spongiform encephalopathies (Creutzfeldt-Jakob andrelated diseases), Alzheimer's, Parkinson's, Huntington's, Wilson'sand Menkes' diseases, as well as in familial amyotrophic lateralsclerosis and others. The interplay between metal ionscatecholamines and the formation of reactive oxygen speciesresulting in oxidative stress is considered, as is themetalloneurochemistry of zinc and the neurotoxicity of aluminumcadmium, lead, and mercury. The need for novel drugs whichmanipulate metal-centered neuropathology is emphasized.

HISTORICAL DEVELOPMENT AND PERSPECTIVES OF THE SERIES.PREFACE TO VOLUME 1.CONTRIBUTORS TO VOLUME 1.TITLES OF VOLUMES 1-44 IN THE METAL IONS IN BIOLOGICALSYSTEMS SERIES.CONTENTS OF VOLUMES IN THE METAL IONS IN LIFE SCIENCESSERIES.1 THE ROLE OF METAL IONS IN NEUROLOGY. ANINTRODUCTION (Dorothea Strozyk and Ashley I. Bush).2 PROTEIN FOLDING, MISFOLDING, AND DISEASE(Jennifer C. Lee, Judy E. Kim, Ekaterina V. Pletneva, JasminFaraone-Mennella, Harry B. Gray, and Jay R. Winkler).3 METAL ION BINDING PROPERTIES OF PROTEINS RELATED TONEURODEGENERATION (Henryk Kozlowski, Marek LuczkowskiDaniela Valensin, and Gianni Valensin).4 METALLIC PRIONS: MINING THE CORE OF TRANSMISSIBLESPONGIFORM ENCEPHALOPATHIES (David R. Brown).5 THE ROLE OF METAL IONS IN THE AMYLOID PRECURSORPROTEIN AND IN ALZHEIMER'S DISEASE (Thomas A. Bayerand Gerd Multhaup).6 THE ROLE OF IRON IN THE PATHOGENESIS OFPARKINSON'S DISEASE (Manfred Gerlach, Kay L. DoubleMario E. Götz, Moussa B. H. Youdim, and PeterRiederer).7 IN VIVO ASSESSMENT OF IRON INHUNTINGTON'S DISEASE AND OTHER AGE-RELATED NEURODEGENERATIVEBRAIN DISEASES (George Bartzokis, Po H. Lu, Todd A. Tishlerand Susan Perlman).8 COPPER-ZINC SUPEROXIDE DISMUTASE AND FAMILIALAMYOTROPHIC LATERAL SCLEROSIS (Lisa J. Whitson and P. JohnHart).9 THE MALFUNCTIONING OF COPPER TRANSPORT IN WILSON ANDMENKES DISEASES (Bibudhendra Sarkar).10 IRON AND ITS ROLE IN NEURODEGENERATIVE DISEASES(Roberta J. Ward and Robert R. Crichton).11 THE CHEMICAL INTERPLAY BETWEEN CATECHOLAMINES ANDMETAL IONS IN NEUROLOGICAL DISEASES (Wolfgang Linert, Guy N.L. Jameson, Reginald F. Jameson, and Kurt A. Jellinger).12 ZINC METALLONEUROCHEMISTRY: PHYSIOLOGY, PATHOLOGYAND PROBES (Christopher J. Chang and Stephen J.Lippard).13 THE ROLE OF ALUMINUM IN NEUROTOXIC ANDNEURODEGENERATIVE PROCESSES (Tamás Kiss, KrisztinaGajda-Schrantz, and Paolo F. Zatta).14 NEUROTOXICITY OF CADMIUM, LEAD, AND MERCURY(Hana R. Pohl, Henry G. Abadin, and John F. Risher).15 NEURODEGENERATIVE DISEASES AND METAL IONS. ACONCLUDING OVERVIEW (Dorothea Strozyk and Ashley I.Bush).SUBJECT INDEX.