Part of the prestigious Novartis Foundation, this is the first book to review the pathology associated with acetaldehyde, a known toxic agent found in cigarette smoke and other pollutants and derived from ingested alcohol, amongst other sources. In the body, acetaldehyde affects several tissues, particularly the brain and liver, causing various diseases, including cancer, alcoholic liver disease and Alzheimer s. Acetaldehyde-Related Pathology describes the toxic effects of acetaldehyde at the tissue and cellular levels, reviewing enzyme biochemistry, transgenic mouse models of alcohol dehydrogenase mutants, and the cell-signalling pathways implicated in alcohol-related pathology. It explores the mechanisms of acetaldehyde-induced damage to tissues, often a first step in carcinogenesis, including the oral cavity, the human airway, and the GI tract. The book considers pharmacological strategies and treatments for reducing oral and intestinal acetaldehyde. Acetaldehyde-Related Pathology features in-depth, round-table discussions by an international array of scientists from major laboratories worldwide involved in studies of acetaldehyde-related pathology. This book is essential reading for anyone interested in the effects of this compound - pathologists, biochemists, toxicologists, cell and molecular biologists.

Part of the prestigious Novartis Foundation, this is the first bookto review the pathology associated with acetaldehyde, a known toxicagent found in cigarette smoke and other pollutants and derivedfrom ingested alcohol, amongst other sources. In the bodyacetaldehyde affects several tissues, particularly the brain andliver, causing various diseases, including cancer, alcoholic liverdisease and Alzheimer's.Acetaldehyde-Related Pathology describes the toxiceffects of acetaldehyde at the tissue and cellular levelsreviewing enzyme biochemistry, transgenic mouse models of alcoholdehydrogenase mutants, and the cell-signalling pathways implicatedin alcohol-related pathology. It explores the mechanisms ofacetaldehyde-induced damage to tissues, often a first step incarcinogenesis, including the oral cavity, the human airway, andthe GI tract. The book considers pharmacological strategies andtreatments for reducing oral and intestinal acetaldehyde.Acetaldehyde-Related Pathology features in-depthround-table discussions by an international array of scientistsfrom major laboratories worldwide involved in studies ofacetaldehyde-related pathology.This book is essential reading for anyone interested in theeffects of this compound - pathologists, biochemiststoxicologists, cell and molecular biologists.

Symposium on Acetaldehyde-related pathology: bridging the trans-disciplinary divide, held at the Novartis Foundation, London 5-7th September 2006Editors: Derek J. Chadwick (Organizer) and Jamie GoodeThis symposium is based on a proposal made by Victor Preedy, Peter Emery and Mikko SalaspuroPeter Emery Chair's introduction 1David W. Crabb and Suthat Liangpunsakul Acetaldehyde generating enzyme systems: roles of alcohol dehydrogenase, CYP2E1 and catalase, and speculations on the role of other enzymes and processes 4Discussion 16Richard A. Deitrich, Dennis Petersen and Vasilis Vasiliou Removal of acetaldehyde from the body 23Discussion 40Shih-Jiun Yin and Giia-Sheun Peng Acetaldehyde, polymorphisms and the cardiovascular system 52Discussion 63Jun Ren Acetaldehyde and alcoholic cardiomyopathy: lessons from the ADH and ALDH2 transgenic models 69Discussion 76Mikko Salaspuro Interrelationship between alcohol, smoking, acetaldehyde and cancer 80Discussion 89Hiroto Matsuse, Chizu Fukushima, Terufumi Shimoda, Sadahiro Asai and Shigeru Kohno Effects of acetaldehyde on human airway constriction and inflammation 97Discussion 106Helmut K. Seitz The role of acetaldehyde in alcohol-associated cancer of the gastrointestinal tract 110Discussion 119Robert Tardif The determination of acetaldehyde in exhaled breath 125Discussion 133Mostofa Jamal, Kiyoshi Ameno, Mitsuru Kumihashi, Weihuan Wang, Ikuo Uekita and Iwao Ijiri Ethanol and acetaldehyde: in vivo quantitation and effects on cholinergic function in rat brain 137Discussion 141Ville Salaspuro Pharmacological treatments and strategies for reducing oral and intestinal acetaldehyde 145Discussion 153Victor R. Preedy, David W. Crabb, Jaume Farrés and Peter W. Emery Alcoholic myopathy and acetaldehyde 158Discussion 177Onni Niemelä Acetaldehyde adducts in circulation 183Discussion 193General discussion 198M. Apte, J. McCarroll, R. Pirola and J. Wilson Pancreatic MAP kinase pathways and acetaldehyde 200Discussion 211Shivendra D. Shukla, Youn Ju Lee, Pil-hoon Park and Annayya R. Aroor Acetaldehyde alters MAP kinase signalling and epigenetic histone modifications in hepatocytes 217Discussion 224Paul J. Thornalley Endogenous ?'-oxoaldehydes and formation of protein and nucleotide advanced glycation endproducts in tissue damage 229Discussion 243C. J. Peter Eriksson Measurement of acetaldehyde: what levels occur naturally and in response to alcohol? 247Discussion 256Final discussion 261Contributors Index 265Subject index 267