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Steroids and Neuronal Activity
ISBN-13:
9780470513996
Veröffentl:
2008
Einband:
E-Book
Seiten:
294
Autor:
Derek J. Chadwick
eBook Typ:
PDF
eBook Format:
Reflowable E-Book
Kopierschutz:
Adobe DRM [Hard-DRM]
Sprache:
Englisch
Beschreibung:
Classical studies of steroid hormones are concerned with their regulation of protein synthesis via the modulation of genomic transcription. But many of the actions of these hormones occur too rapidly to be explained in this manner, particularly their effects on the central nervous system. This text deals with recent discoveries showing that steroids can modulate the activity of some neurotransmitters. It explores the role of GABA as an important regulator of neuronal activity in the central nervous system and its inhibitory action as mediated via the GABA receptor and potentiated by steroids. In addition, the binding of steroids to cell membranes, the components involved and the outcome of such interactions are described. Also discusses possible uses of steroids as anesthetics and anticonvulsants.
Classical studies of steroid hormones are concerned with their regulation of protein synthesis via the modulation of genomic transcription. But many of the actions of these hormones occur too rapidly to be explained in this manner, particularly their effects on the central nervous system. This text deals with recent discoveries showing that steroids can modulate the activity of some neurotransmitters. It explores the role of GABA as an important regulator of neuronal activity in the central nervous system and its inhibitory action as mediated via the GABA receptor and potentiated by steroids. In addition, the binding of steroids to cell membranes, the components involved and the outcome of such interactions are described. Also discusses possible uses of steroids as anesthetics and anticonvulsants.
Partial table of contents:Steroid Effects on Neuronal Activity: When Is the GenomeInvolved?(B. McEwen, et al.).Steroid Binding at sigma Receptors: CNS and ImmunologicalImplications (T. Su, et al.).Effects of Progesterone and Its Metabolites on NeuronalMembranes (V. Ramirez, et al.).Effect of Oestradiol on Dopamine Receptors and Protein Kinase CActivity in the Rat Pituitary: Binding of Oestradiol to PituitaryMembranes (D. Joubert-Bression, et al.).Effects of Prostaglandin E2 and Progesterone on Rat BrainSynaptosomal Plasma Membranes (G. Deliconstantinos).Steroids and Neuronal Destruction or Stabilization (E.Hall).Early and Late Effects of Steroid Hormones on the CentralNervous System (B. Dubrovsky, et al.).Index of Contributors.Subject Index.