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Autor: Brian E. Cairns
ISBN-13: 9780470522219
Einband: E-Book
Seiten: 528
Sprache: Englisch
eBook Typ: PDF
eBook Format: E-Book
Kopierschutz: Adobe DRM [Hard-DRM]
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Peripheral Receptor Targets for Analgesia

Novel Approaches to Pain Management
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A unique reference on peripheral pain receptor mechanisms
While considerable advances have been made on pharmacotherapiesfor many chronic disease states, options available to treat chronicpain have remained relatively unchanged for decades. However,utilizing the receptors involved in peripheral pain transductionmechanisms offers a significant opportunity to create noveltherapies for pain.

A comprehensive review of peripheral pain mechanisms,Peripheral Receptor Targets for Analgesia: Novel Approaches toPain Management provides a unique resource that brings togethera body of knowledge that was previously widely dispersed. As such,it gives readers a framework for further basic and clinical studieson potential receptor targets, as well as the development ofimproved topical analgesics.

Coverage includes:
* The latest discoveries by leading researchers relating to thefunction of various ion channels and receptors in the peripheralnervous system
* Novel delivery techniques
* An appendix listing currently available topical analgesicmedications
* A Foreword by Professor Lars Arendt-Nielsen of the Center forSensory-Motor Interaction (SMI) at Aalborg University

An unmatched resource for improving drug therapies and makingpain management more efficient, Peripheral Receptor Targets forAnalgesia supplies pharmaceutical scientists, pharmacologists,neuroscientists, and graduate and upper-level undergraduatestudents with a comprehensive, up-to-date reference.
FOREWORD by Lars Arendt-Nielsen.

PREFACE.

CONTRIBUTORS.

PART I PERIPHERAL MECHANISM IN CLINICAL PAINCONDITIONS.

1. Role of Peripheral Mechanisms in Craniofacial Pain Conditions(Barry J. Sessle).

2. Role of Peripheral Mechanisms in Spinal Pain Conditions(Brian E. Cairns and Pradit Prateepavanich).

PART II SPECIFIC RECEPTOR TARGETS FOR PERIPHERALANALGESICS.

3. Voltage-Gated Sodium Channels in Peripheral NociceptiveNeurons as Targets For the Treatment of Pain (Theodore R.Cummins).

4. Potassium Channels (Daisuke Nishizawa1, Toru Kobayashi,and Kazutaka Ikeda).

5. Voltage-Gated Calcium Channels as Targets for the Treatmentof Chronic Pain (Joe McGivern).

6. Adenosine Receptors (Jana Sawynok).

7. Acid-Sensing Ion Channels and Pain (Roxanne Y. Walder,Christopher J. Benson and Kathleen A. Sluka).

8. Vanilloid (TRPV1) and Other Transient Receptor PotentialChannels (Marcello Trevisani and Arpad Szallasi).

9. Glutamate Receptors (Brian E. Cairns).

10. Serotonin Receptors (Malin Ernberg).

11. Adrenergic Receptors (Antti Pertovaara).

12. Cholinergic Receptors and Botulinum Toxin (ParisaGazerani).

13. Cannabinoids and Pain Control in the Periphery (Jason J.McDougall).

14. Opioid Receptors (Claudia Herrera Tambeli, Luana Fischerand Carlos Amilcar Parada).

15. Calcitonin Gene-Related Peptide and Substance P(Ranjinidevi Ambalavanar and Dean Dessem).

16. Role of Somatostatin and Somatostatin Receptors in Pain(Ujendra Kumar).

17. Cytokines (Tumor Necrosis Factor, Interleukins) andProstaglandins (Per Alstergren).

18. Neurotrophic Factors and Pain (Peter Svensson).

PART III DELIVERY SYSTEMS.

19. Topical and Systemic Drug Delivery Systems Targeted DrugTherapy (Urs Hafeli and Amit Kale).

20. Gene Therapy for Pain (Marina Mata and David J.Fink).

21. Topical Analgesics (Akhlaq Waheed Hakim and Brian E.Cairns).

Index.

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Autor: Brian E. Cairns
ISBN-13 :: 9780470522219
ISBN: 0470522216
Verlag: John Wiley & Sons
Seiten: 528
Sprache: Englisch
Auflage 1. Auflage
Sonstiges: Ebook