Monitoring is a major component of management of chronic diseases such as diabetes, cardiovascular disease, arthritis and depression. Yet poor monitoring means healthcare costs are rising. This book discusses how monitoring principles adopted in other spheres such as clinical pharmacology and evidence-based medicine can be applied to chronic disease in the global setting. With contributions from leading experts in evidence-based medicine, it is a ground-breaking text for all involved in delivery of better and more effective management of chronic illnesses.

Monitoring is a major component of management of chronic diseasessuch as diabetes, cardiovascular disease, arthritis and depression.Yet poor monitoring means healthcare costs are rising.This book discusses how monitoring principles adopted in otherspheres such as clinical pharmacology and evidence-based medicinecan be applied to chronic disease in the global setting. Withcontributions from leading experts in evidence-based medicine, itis a ground-breaking text for all involved in delivery of betterand more effective management of chronic illnesses.

Contributors.Part 1 The Theory of Monitoring.INTRODUCTORY MATERIAL.1 An introduction to monitoring therapeutic interventions inclinical practice (Paul P. Glasziou, University of Oxford; JeffreyK. Aronson, University of Oxford).2 A framework for developing and evaluating a monitoringstrategy (David Mant, University of Oxford).THE MEASUREMENT.3 Developing monitoring tools: integrating the pathophysiologyof disease and the mechanisms of action of therapeuticinterventions (Jeffrey K. Aronson, University of Oxford; SusanMichie, University College London).4 Biomarkers and surrogate endpoints in monitoring therapeuticinterventions (Jeffrey K. Aronson, University of Oxford).5 Choosing the best monitoring tests (Les Irwig, University ofSydney; Paul P. Glasziou, University of Oxford).THE CONTROL PHASES.6 Monitoring the initial response to treatment (Katy BellUniversity of Sydney; Jonathan Craig, University of Sydney; LesIrwig, University of Sydney).7 Control charts and control limits in long-term monitoring(Petra Macaskill, University of Sydney).8 Developing a monitoring schedule: frequency of measurement(Andrew J. Farmer, University of Oxford).9 How should we adjust treatment? (Paul P. Glasziou, Universityof Oxford).THE PSYCHOLOGY OF MONITORING.10 Monitoring as a learning and motivational tool (Susan MichieUniversity College London; Kirsten McCaffery, University ofSydney); Carl Heneghan, University of Oxford).11 Monitoring from the patient's perspective: the social andpsychological implications (Kirsten McCaffery, University ofSydney; Susan Michie, University College London).THE EVALUATION OF MONITORING TECHNIQUES.12 Evaluating the effectiveness and costs of monitoring (PatrickM.M. Bossuyt, University of Amsterdam).13 Good practice in delivering laboratory monitoring (W. StuartA. Smellie, Bishop Auckland Hospital, County Durham).14 Point-of-care testing in monitoring (Christopher P. PriceUniversity of Oxford).15 Monitoring for the adverse effects of drugs (Jamie J.Coleman, Queen Elizabeth Hospital, Birmingham; Robin E. FernerCity Hospital, Birmingham; Jeffrey K. Aronson, University ofOxford).Part 2 The Practice of Monitoring.16 Monitoring diabetes mellitus across the lifetime of illness(Andrew J. Farmer, University of Oxford).17 Oral anticoagulation therapy (OAT) (Carl Heneghan, Universityof Oxford; Rafael Perera, University of Oxford).18 Monitoring cholesterol-modifying interventions (Paul P.Glasziou, University of Oxford; Les Irwig, University of Sydney;Stephane Heritier, (University of Sydney).19 Monitoring levothyroxine replacement in primaryhypothyroidism (Andrea Rita Horvath, University of Szeged).20 Monitoring in renal transplantation (Nicholas B. CrossUniversity of Sydney; Jonathan Craig, University of Sydney).21 Monitoring in pre-eclampsia (Pisake Lumbiganon, Khon KaenUniversity; Malinee Laopaiboon, Khon Kaen University).22 Monitoring in intensive care (Jan M. Binnekade, University ofAmsterdam; Patrick M.M. Bossuyt, University of Amsterdam).23 Monitoring intraocular pressure in glaucoma (Les IrwigUniversity of Sydney; Paul R. Healey, University of Sydney;Jefferson D'Assunsao, University of Sydney; PetraMacaskill, University of Sydney).24 Monitoring in osteoarthritis (George Peat, Keele University;Mark Porcheret, Keele University; John Bedson, Keele University;Alison M. Ward, University of Oxford).Index.