With the recent renaissance in mitochondrial biology and increasing recognition of their role in many diseases, this book provides a timely summary of the current state-of-the-art in mitochondrial research. The book opens with the regulation of mitochondrial replication and biogenesis and reviews the mechanisms and functional consequences of mitochondrial fission and fusion. Further chapters address mitochondria and oxidative stress and their roles in cell signalling and cell death. The book includes extensive, fascinating discussion of the biochemistry of mitochondrial cell signalling (especially involving calcium) and of oxidative stress. The nature of the proteins engaged in these processes, many only recently discovered, is covered in detail. Mitochondria have been strongly implicated in neurodegenerative diseases such as Parkinson s, Huntington s and amyotrophic lateral sclerosis. They are also affected in cancer, ageing and cardiovascular disease. The final section of the book reviews mitochondrial mutations and their consequences in ageing and other phenotypic manifestations. The authors discuss how mitochondrial proteins might constitute important therapeutic targets and describe initial attempts to develop compounds that can regulate their function.

With the recent renaissance in mitochondrial biology and increasingrecognition of their role in many diseases, this book provides atimely summary of the current state-of-the-art in mitochondrialresearch. The book opens with the regulation of mitochondrialreplication and biogenesis and reviews the mechanisms andfunctional consequences of mitochondrial fission and fusion.Further chapters address mitochondria and oxidative stress andtheir roles in cell signalling and cell death. The book includesextensive, fascinating discussion of the biochemistry ofmitochondrial cell signalling (especially involving calcium) and ofoxidative stress. The nature of the proteins engaged in theseprocesses, many only recently discovered, is covered in detail.Mitochondria have been strongly implicated in neurodegenerativediseases such as Parkinson's, Huntington's andamyotrophic lateral sclerosis. They are also affected in cancerageing and cardiovascular disease. The final section of the bookreviews mitochondrial mutations and their consequences in ageingand other phenotypic manifestations. The authors discuss howmitochondrial proteins might constitute important therapeutictargets and describe initial attempts to develop compounds that canregulate their function.

Symposium on New perspectives on mitochondrial biolog y, held atthe Novartis Foundation, London, 28-30 November 2006.Editors: Derek J. Chadwick (Organizer) and Jamie Goode.This symposium is based on a proposal by Michael Duchen.David G. Nicholls Chair's introduction.Albert Neutzner, Richard J. Youle and MariuszKarbowski, Outer mitochondrial membrane protein degradation bythe proteasome.Discussion.Sarah E. Haigh, Gilad Twig, Anthony A. J. Molina, Jakob D.Wikstrom, Motti Deutsch and Orian S. ShirihaiPA-GFP: a window into the subcellular adventures of the individualmitochondrion.Discussion.Luca Scorrano, Multiple functions of mitochondria-shapingproteins. Discussion.Bruce M. Spiegelman, Transcriptional control ofmitochondrial energy metabolism through the PGC1coactivators.Discussion.Charles Affourtit, Paul G. Crichton, Nadeene Parker andMartin D. Brand, Novel uncoupling proteins.Discussion.Cecilia Giulivi, Mitochondria as generators and targetsof nitric oxide. Discussion.György Hajnóczky, Masao Saotome, GyörgyCsordás, David Weaver and Muqing Yi, Calciumsignalling and mitochondrial motility.Discussion.Anna Romagnoli, Paola Aguiari, Diego De Stefani, SaraLeo, Saverio Marchi, Alessandro Rimessi, Erika ZecchiniPaolo Pinton and Rosario Rizzuto, Endoplasmicreticulum/mitochondria calcium cross-talk.Discussion.Brian O'Rourke, Sonia Cortassa, Fadi Akar andMiguel Aon, Mitochondrial ion channels in cardiac functionand dysfunction.Discussion.Paolo Bernardi and Michael Forte, Themitochondrial permeability transition pore.Discussion.Dominic James, Philippe A. Parone, Olivier TerradillosSafa Lucken-Ardjomande, Sylvie Montessuit and Jean-ClaudeMartinou, Mechanisms of mitochondrial outer membranepermeabilization.Discussion.M. Flint Beal, Mitochondria and neurodegeneration.Discussion.Mügen Terzioglu and Nils-Göran LarssonMitochondrial dysfunction in mammalian ageing.Discussion.Eric A. Schon and Salvatore DiMauro. Mitochondrialmutations: genotype to phenotype.Discussion.Contributor Index.Subject index.