Osteoarthritis is a chronic degenerative disease associated with joint pain and loss of joint function. It has an estimated incidence of 4 out of every 100 people and significantly reduces the quality of life in affected individuals. The major symptoms are chronic pain, swelling and stiffness; severe, chronic joint pain is often the central factor that causes patients to seek medical attention. Within the affected joint, there is focal degradation and remodelling of articular cartilage, new bone formation (osteophytes) and mild synovitis. Several mechanisms are thought to contribute to osteoarthritic joint pain. These include mild synovial inflammation, bone oedema, ligament stretching, osteophyte formation and cartilage-derived mediators. Changes in joint biomechanics and muscle strength also influence the severity and duration of joint pain in osteoarthritis. Within the nervous system, the relative contributions of peripheral afferent nociceptive fibres and central mechanisms remain to be defined, and there is limited information on the phenotype of sensory neurons in the OA joint. Importantly, there is no relation between clinical severity, as measured by radiographic changes, and the presence and severity of joint pain. Patients with severe joint pain may have normal joint architecture as determined by X-ray, whereas patients with considerable evidence of joint remodelling may not have significant joint pain. Treatments for osteoarthritic joint pain include non-steroidal anti-inflammatory compounds, exercise, corrective shoes and surgical intervention. There remains a critical need for improved control of joint pain in osteoarthritis. This book brings together contributions from key investigators in the area of osteoarthritic joint pain. It covers the clinical presentation of joint pain, the pathways involved in joint pain, osteoarthritis disease processes and pain, experimental models and pain control. The discussions provide insights into the nature of osteoarthritic joint pain, identify key studies needed to advance understanding of the problem, highlight possible intervention points and indicate future pathways towards a better treatment of osteoarthritic joint pain.

Osteoarthritis is a chronic degenerative disease associated withjoint pain and loss of joint function. It has an estimatedincidence of 4 out of every 100 people and significantly reducesthe quality of life in affected individuals. The major symptoms arechronic pain, swelling and stiffness; severe, chronic joint pain isoften the central factor that causes patients to seek medicalattention. Within the affected joint, there is focal degradationand remodelling of articular cartilage, new bone formation(osteophytes) and mild synovitis.Several mechanisms are thought to contribute to osteoarthriticjoint pain. These include mild synovial inflammation, bone oedemaligament stretching, osteophyte formation and cartilage-derivedmediators. Changes in joint biomechanics and muscle strength alsoinfluence the severity and duration of joint pain inosteoarthritis. Within the nervous system, the relativecontributions of peripheral afferent nociceptive fibres and centralmechanisms remain to be defined, and there is limited informationon the phenotype of sensory neurons in the OA joint. Importantlythere is no relation between clinical severity, as measured byradiographic changes, and the presence and severity of joint pain.Patients with severe joint pain may have normal joint architectureas determined by X-ray, whereas patients with considerable evidenceof joint remodelling may not have significant joint pain.Treatments for osteoarthritic joint pain include non-steroidalanti-inflammatory compounds, exercise, corrective shoes andsurgical intervention. There remains a critical need for improvedcontrol of joint pain in osteoarthritis.This book brings together contributions from key investigatorsin the area of osteoarthritic joint pain. It covers theclinical presentation of joint pain, the pathways involved in jointpain, osteoarthritis disease processes and pain, experimentalmodels and pain control. The discussions provide insights intothe nature of osteoarthritic joint pain, identify key studiesneeded to advance understanding of the problem, highlight possibleintervention points and indicate future pathways towards a bettertreatment of osteoarthritic joint pain.

Chair's Introduction (D. Felson).Spinal mechanisms contributing to joint pain (H. Schaible).Activation of sensory neurons in the arthritic joint (B.Grubb).Neuromuscular aspects of osteoarthritis: a perspective (K.Brandt).Current perspectives on the clinical presentation of joint painin human osteoarthritis (P. Creamer).Joint mechanics in osteoarthritis (W. Herzog, etal.).General discussion I Developing animal models of RA.Characterization of joint pain in human osteoarthritis (G.Ordeberg).The role of inflammatory mediators on nociception and pain inarthritis (B. Kidd, et al.).Molecular events of chronic pain: from neurone to whole animalin an animal model of osteoarthritis (J. Henry).Phantoms of rheumatology (C. McCabe, et al.).Bone pain and pressure in osteoarthritic joints (P. Simkin).Structural associations of osteoarthritis pain: lessons frommagnetic resonance imaging (P. Conaghan & D. Felson).The role of TRP channels in sensory neurons (M. Koltenberg)Mechanisms that generate and maintain bone cancer pain (P.Mantyh & S. Hunt).Symmetry, T cells and neurogenic arthritis (N. Shenker, etal.).Lessons from fibromyalgia: abnormal pain sensitivity in kneeostheoarthritis (L. Bradley, et al.).Chair's summing up (D. Felson).Index of contributors.Subject index.