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Physics of Cancer
Beschreibung:
Physics of Cancer emphasizes a novel biophysical-based view on cancer disease and metastasis highlighting the functional role of mechanical properties of cells while describing the biological state of cancer. Originating in part from the author’s own courses on tumor biology and cellular biophysics, this book is suitable for students and researchers in this dynamic interdisciplinary field, be they from a physical, biological or medical sciences background.
Physics of Cancer focuses on the mechanical properties of cancer cells and their role in cancer disease and metastasis. It discusses the role of the mechanical properties of interacting cells and the connective tissue microenvironment and describes the role of an inflammation during cancer disease. This outstanding book is the first to describe cancer disease from a biophysical point of view without being incomplete in describing the biological site of cancer. Originating in part from the author’s own courses on tumor biology and cellular biophysics, this book is suitable for both students and researchers in this dynamic interdisciplinary field, be they from a physical, biological or medical sciences background.
Preface
About the author
Introduction
Part 1 Introduction to tumor biology from a biophysical point of view
1 Initiation of a neoplasm or tumor
2 Inflammation and cancer
Part 2 The role of the mechanical properties of cancer cells in cellular invasion
3 Cellular stiffness and deformability
4 Cell–cell and cell–matrix adhesion strength, local cell stiffness and forces
5 Cytoskeletal remodeling dynamics
6 Intermediate filaments and nuclear deformability during matrix invasion
7 Cell surface tension, the mobility of cell surface receptors and their location in specific regions
Part 3 The impact of the tumor microenvironment on cellular
invasion
8 The mechanical and structural properties of the microenvironment
9 The impact of cells and substances within the extracellular matrix tissue on mechanical properties and cell invasion
Part 4 The impact of the mechanical and biochemical interaction of cancer cells with other cells in transendothelial migration
10 The role of endothelial cell-cell adhesions 10-1
11 The mechanical properties of endothelial cells altered by aggressive cancer cells
12 The role of macrophages during cancer cell transendothelial migration
References
Physics of Cancer focuses on the mechanical properties of cancer cells and their role in cancer disease and metastasis. It discusses the role of the mechanical properties of interacting cells and the connective tissue microenvironment and describes the role of an inflammation during cancer disease. This outstanding book is the first to describe cancer disease from a biophysical point of view without being incomplete in describing the biological site of cancer. The author combines the biochemical, medical, cell biological and physical views of cancer by highlighting the importance of the mechanical properties of cancer cells and their microenvironment.
This book is written for scientists and everyone interested in the rapidly growing field of physics of cancer. It connects and discusses researchers’ findings from different fields and points out the importance of the mechanical properties of cells for the understanding of cancer disease. With extensive references and further reading suggestions, it will further improve the knowledge of the reader and guide them through this complex and growing field of cancer research. Originating in part from the author’s own courses on tumor biology and cellular biophysics, this book is suitable for both students and researchers in this dynamic interdisciplinary field, be they from a physical, biological or medical sciences background.