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Continuous Biopharmaceutical Processes
Chromatography, Bioconjugation, and Protein Stability
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ISBN-13:
9781108420228
Veröffentl:
2018
Erscheinungsdatum:
11.10.2018
Seiten:
346
Autor:
David Pfister
Gewicht:
810 g
Format:
266x179x4 mm
Sprache:
Englisch
Beschreibung:
David Pfister is project manager at Ypso Facto (Nancy, France), where he is developing the software ChromWorks, which has been used to perform the large majority of the simulations of chromatographic processes shown in this book. He was a doctorate student of Professor Morbidelli at Eidgenössische Technische Hochschule Zürich (ETH Zurich) and graduated in 2015. His Ph.D. thesis focused on protein conjugation, and his research also dealt with the fundamental understanding of protein chromatography. Before joining ETH Zurich, he obtained a master degree in chemical engineering from École Nationale Supérieure des Industries Chimiques (Nancy, France).
Preface; 1. Introduction to biopharmaceutical processes; 2. Fundamentals of protein chromatography; 3. Counter-current separation processes; 4. Counter-current chromatography for the capture step; 5. Counter-current chromatography for the polishing steps; 6. Protein conjugation; 7. Protein aggregation in biopharmaceutical processes; 8. Conclusion; References; Notation; Index.
Provides a coherent and critical view on the potential benefits of various continuous processes in the biopharmaceutical industry.