An essential outline of the main facets of polypharmacology in drug discovery research Extending drug discovery opportunities beyond the "e;one drug, one target"e; philosophy, a polypharmacological approach to the treatment of complex diseases is emerging as a hot topic in both industry and academic research. Polypharmacology in Drug Discovery presents an overview of the various facets of polypharmacology and how it can be applied as an innovative concept for developing medicines for treating bacterial infections, epilepsy, cancer, psychiatric disorders, and more. Filled with a collection of instructive case studies that reinforce the material and illuminate the subject, this practical guide: Covers the two-sided nature of polypharmacology its contribution to adverse drug reactions and its benefit in certain therapeutic drug classes Addresses the important topic of polypharmacology in drug discovery, a subject that has not been thoroughly covered outside of scattered journal articles Overviews state-of-the-art approaches and developments to help readers understand concepts and issues related to polypharmacology Fosters interdisciplinary drug discovery research by embracing computational, synthetic, in vitro and in vivo pharmacological and clinical aspects of polypharmacology A clear road map for helping readers successfully navigate around the problems involved with promiscuous ligands and targets, Polypharmacology in Drug Discovery provides real examples, in-depth explanations and discussions, and detailed reviews and opinions to spark inspiration for new drug discovery projects.

An essential outline of the main facets of polypharmacology indrug discovery researchExtending drug discovery opportunities beyond the "one drug, onetarget" philosophy, a polypharmacological approach to the treatmentof complex diseases is emerging as a hot topic in both industry andacademic research. Polypharmacology in Drug Discovery presents anoverview of the various facets of polypharmacology and how it canbe applied as an innovative concept for developing medicines fortreating bacterial infections, epilepsy, cancer, psychiatricdisorders, and more. Filled with a collection of instructive casestudies that reinforce the material and illuminate the subjectthis practical guide:* Covers the two-sided nature of polypharmacology--itscontribution to adverse drug reactions and its benefit in certaintherapeutic drug classes* Addresses the important topic of polypharmacology in drugdiscovery, a subject that has not been thoroughly covered outsideof scattered journal articles* Overviews state-of-the-art approaches and developments to helpreaders understand concepts and issues related topolypharmacology* Fosters interdisciplinary drug discovery research by embracingcomputational, synthetic, in vitro and in vivo pharmacological andclinical aspects of polypharmacologyA clear road map for helping readers successfully navigatearound the problems involved with promiscuous ligands and targetsPolypharmacology in Drug Discovery provides real examples, in-depthexplanations and discussions, and detailed reviews and opinions tospark inspiration for new drug discovery projects.