Explores the latest science on dioxins and other POPs, and their impact on human health Now in its third edition, Dioxins and Health is the most respected reference of its kind, presenting the latest scientific findings on dioxins, dibenzofurans, polychlorinated biphenyls and related compounds, and their impact on human health. The book fully examines the many toxicological effects including immunological, neurological, developmental, dermatological, and cardiological these chemicals have on health. This Third Edition has been greatly expanded with the latest research findings on dioxins and related compounds. Moreover, it now includes coverage of other persistent organic pollutants (POPs) and endocrine disruptors, including: Brominated flame retardants, such as polybrominated diphenyl ethers and hexabromocyclododecane Perfluorinated chemicals such as perfluorooctanoic acid and perfluorooctanesulfonic acid Other endocrine disrupting chemicals similar to POPs such as bisphenol A Readers will also learn about the latest findings on the long-term impacts caused by the use of Agent Orange in Vietnam. Other chapters review the Seveso disaster in Italy and the Yusho and Yucheng rice oil poisoning incidents in Japan and Taiwan. In addition, there is a full chapter dedicated to the dioxin poisoning of former Ukraine President Victor Yushchenko. All the chapters in the book have been written by leading international experts. References at the end of each chapter guide readers to the primary literature in the field. Expertly organized in one volume, Dioxins and Health offers readers quick access to essential information about dioxins and related compounds written in clear, simple language that is accessible to not only scientists, clinicians and public health professionals, but also general readers.

Explores the latest science on dioxins and other POPs, and theirimpact on human healthNow in its third edition, Dioxins and Health is the mostrespected reference of its kind, presenting the latest scientificfindings on dioxins, dibenzofurans, polychlorinated biphenyls andrelated compounds, and their impact on human health. The book fullyexamines the many toxicological effects--includingimmunological, neurological, developmental, dermatological, andcardiological--these chemicals have on health.This Third Edition has been greatly expanded with thelatest research findings on dioxins and related compounds.Moreover, it now includes coverage of other persistent organicpollutants (POPs) and endocrine disruptors, including:* Brominated flame retardants, such as polybrominated diphenylethers and hexabromocyclododecane* Perfluorinated chemicals such as perfluorooctanoic acid andperfluorooctanesulfonic acid* Other endocrine disrupting chemicals similar to POPs such asbisphenol AReaders will also learn about the latest findings on thelong-term impacts caused by the use of Agent Orange in Vietnam.Other chapters review the Seveso disaster in Italy and the Yushoand Yucheng rice oil poisoning incidents in Japan and Taiwan. Inaddition, there is a full chapter dedicated to the dioxin poisoningof former Ukraine President Victor Yushchenko.All the chapters in the book have been written by leadinginternational experts. References at the end of each chapter guidereaders to the primary literature in the field.Expertly organized in one volume, Dioxins and Healthoffers readers quick access to essential information about dioxinsand related compounds written in clear, simple language that isaccessible to not only scientists, clinicians and public healthprofessionals, but also general readers.

PREFACE xiACKNOWLEDGMENT xviABOUT THE EDITOR xviiCONTRIBUTORS xixLIST OF TABLES AND FIGURES xxiii1 PERSISTENT ORGANIC POLLUTANTS: AN OVERVIEW 1Daniele Wikoff, Lauren Fitzgerald, and LindaBirnbaum2 TOXICITY EQUIVALENCE FACTORS FOR DIOXIN AND RELATED COMPOUNDS37Michael DeVito3 HISTORIC AND NEWER PERSISTENT ORGANIC POLLUTANTS IN FOOD53Janice Huwe4 FLAME RETARDANTS: POLYBROMINATED DIPHENYL ETHERS AND THEIRREPLACEMENTS 89Thomas F. Webster and Heather M. Stapleton5 PHARMACOKINETICS OF 2,3,7,8-TETRACHLORODIBENZO-AND RELATEDCOMPOUNDS P-DIOXIN 109James R. Olson6 IMMUNOMODULATION BY PERSISTENT ORGANIC POLLUTANTS171Robert W. Luebke, Jamie C. DeWitt, Dori R. Germolec, Keith D.Salazar, and Nancy I. Kerkvliet7 DEVELOPMENTAL NEUROTOXICITY OF DIOXINS 193G. Jean Harry and Pamela J. Lein8 EPIDEMIOLOGICAL EVIDENCE ON THE HEALTH EFFECTS OFPERFLUOROOCTANOIC ACID 229Kyle Steenland, Tony Fletcher, and David A. Savitz9 POLYBROMINATED P-DIOXINS AND DIBENZO-DIBENZOFURANS255Kurunthachalam Kannan, Chunyang Liao, and Hyo-Bang Moon10 EPIDEMIOLOGICAL STUDIES ON CANCER AND EXPOSURE TO DIOXINS ANDRELATED COMPOUNDS 303Lennart Hardell and Mikael Eriksson11 REPRODUCTIVE AND DEVELOPMENTAL EPIDEMIOLOGY OF DIOXINS359Anne Sweeney, Deborah J. del Junco, Marcella Warner, and BrendaEskenazi12 BISPHENOL A 381Thaddeus T. Schug, Sarah A. Vogel, Laura N. Vandenberg, Joe M.Braun, Russ Hauser, Julia A. Taylor, Frederick S. vom Saal, andJerold J. Heindel13 PHTHALATES: HUMAN EXPOSURE AND RELATED HEALTH EFFECTS415John D. Meeker and Kelly K. Ferguson14 THE SEVESO ACCIDENT 445Angela Cecilia Pesatori and Pier Alberto Bertazzi15 AGENT ORANGE: HEALTH AND ENVIRONMENTAL ISSUES IN VIETNAMCAMBODIA, AND LAOS 469Susan Hammond and Arnold Schecter16 THE YUSHO AND YUCHENG RICE OIL POISONING INCIDENTS521Yoshito Masuda and Arnold Schecter17 THE BINGHAMTON, NEW YORK, ELECTRICAL TRANSFORMER FIREINCIDENT OF 1981 553Nancy Kim and Arnold Schecter18 THE YUSHCHENKO DIOXIN POISONING: CHRONOLOGY ANDPHARMACOKINETICS 567John Jake Ryan19 POPs AND HUMAN HEALTH RISK ASSESSMENT 579David T. Szabo and Anne E. LoccisanoINDEX 619