Examines new research on the role of cholesterol in regulating ion channels and receptors and its effect on health Drawing together and analyzing all the latest research findings, this book explores the role of cholesterol in the regulation of ion channels and receptors, including its pathological effects. It is the first book to comprehensively describe the complex mechanisms by which cholesterol regulates two major classes of membrane proteins. Moreover, it sheds new light on how cholesterol affects essential cellular functions such as the contraction of the heart, propagation of nerve impulses, and regulation of blood pressure and kidney function. Written and edited by leading pioneers in the field, Cholesterol Regulation of Ion Channels and Receptors is divided into three parts: Part I, Cholesterol Regulation of Membrane Properties, introduces the heterogeneity of cholesterol distribution in biological membranes and the physical and biological implications of the formation of cholesterol-rich membrane domains. Part II, Cholesterol Regulation of Ion Channels, examines the mechanisms underlying cholesterol sensitivities of ion channels, including the regulation of ion channels by cholesterol as a boundary lipid. Part III, Cholesterol Regulation of Receptors, explores the latest discoveries concerning how cholesterol regulates distinct types of receptors, including G-protein coupled receptors, LDL and scavenger receptors, and innate immune system receptors. Increased levels of cholesterol represent a major health risk. Understanding cholesterol regulation of ion channels and receptors is essential for facilitating the development of new therapeutic strategies to alleviate the impact of pathological cholesterol conditions. With this book as their guide, readers have access to the most current knowledge in the field.

Examines new research on the role of cholesterol inregulating ion channels and receptors and its effect onhealthDrawing together and analyzing all the latest research findingsthis book explores the role of cholesterol in the regulation of ionchannels and receptors, including its pathological effects. It isthe first book to comprehensively describe the complex mechanismsby which cholesterol regulates two major classes of membraneproteins. Moreover, it sheds new light on how cholesterol affectsessential cellular functions such as the contraction of the heartpropagation of nerve impulses, and regulation of blood pressure andkidney function.Written and edited by leading pioneers in the fieldCholesterol Regulation of Ion Channels and Receptors isdivided into three parts:* Part I, Cholesterol Regulation of Membrane Propertiesintroduces the heterogeneity of cholesterol distribution inbiological membranes and the physical and biological implicationsof the formation of cholesterol-rich membrane domains.* Part II, Cholesterol Regulation of Ion Channelsexamines the mechanisms underlying cholesterol sensitivities of ionchannels, including the regulation of ion channels by cholesterolas a boundary lipid.* Part III, Cholesterol Regulation of Receptors, exploresthe latest discoveries concerning how cholesterol regulatesdistinct types of receptors, including G-protein coupled receptorsLDL and scavenger receptors, and innate immune systemreceptors.Increased levels of cholesterol represent a major health risk.Understanding cholesterol regulation of ion channels and receptorsis essential for facilitating the development of new therapeuticstrategies to alleviate the impact of pathological cholesterolconditions. With this book as their guide, readers have access tothe most current knowledge in the field.

FOREWORD viiPREFACE ixCONTRIBUTORS xiI CHOLESTEROL REGULATION OF MEMBRANE PROPERTIES 11 CHOLESTEROL TRAFFICKING AND DISTRIBUTION BETWEEN CELLULARMEMBRANES 3Daniel Wu¨ stner, Lukasz Michael Solanko, and Frederik W.Lund2 CHOLESTEROL REGULATION OF MEMBRANE PROTEIN FUNCTION BY CHANGESIN BILAYER PHYSICAL PROPERTIES--AN ENERGETIC PERSPECTIVE27Jens A. Lundbæk and Olaf S. AndersenII CHOLESTEROL REGULATION OF ION CHANNELS 453 INSIGHTS INTO STRUCTURAL DETERMINANTS OF CHOLESTEROLSENSITIVITY OF KIR CHANNELS 47Avia Rosenhouse-Dantsker and Irena Levitan4 ROLE OF LIPID RAFTS IN THE REGULATION OF STORE-OPERATED CA2+CHANNELS 69Hwei L. Ong and Indu S. Ambudkar5 CHOLESTEROL REGULATION OF CARDIAC ION CHANNELS 91Elise Balse, Ste´ phane Hatem, and Stanley Nattel6 DIFFERENTIAL CONTRIBUTION OF BK SUBUNITS TO NONGENOMICREGULATION OF CHANNEL FUNCTION BY STEROIDS 109Alex M. Dopico, Anna N. Bukiya, and Aditya K. Singh7 REGULATION OF K+ CHANNELS BY CHOLESTEROL-RICH MEMBRANE DOMAINSIN THE IMMUNE SYSTEM 135Nu´ ria Comes and Antonio Felipe8 INDIRECT CHANNEL REGULATION BY CHOLESTEROL: THE ROLE OFCAVEOLAE AND CAVEOLINS IN REGULATING KATP CHANNEL FUNCTION161Caroline DartIII CHOLESTEROL REGULATION OF RECEPTORS 1819 REGULATION OF THE NICOTINIC ACETYLCHOLINE RECEPTOR BYCHOLESTEROL AS A BOUNDARY LIPID 183Francisco J. Barrantes10 SPECIFIC AND NONSPECIFIC REGULATION OF GPCR FUNCTION BYCHOLESTEROL 205Gerald Gimpl and Katja Gehrig-Burger11 STRUCTURAL INSIGHTS INTO CHOLESTEROL INTERACTIONS WITHG-PROTEIN-COUPLED RECEPTORS 231Jeremiah S. Joseph, Enrique E. Abola, and Vadim Cherezov12 MEMBRANE CHOLESTEROL: IMPLICATIONS IN RECEPTOR FUNCTION255Sandeep Shrivastava and Amitabha Chattopadhyay13 THE ROLE OF CHOLESTEROL AND LIPID RAFTS IN REGULATION OF TLRRECEPTORS 273Ruxana T. SadikotINDEX 281