All the latest tools needed to plan and perform the synthesis of complex bioactive molecules Focusing on organic, organometallic, and bio-oriented processes, this book explores the impact and use of the latest synthetic tools for the synthesis of complex biologically active compounds. Readers will discover step by step how these synthetic tools have provided new, elegant solutions to many synthetic puzzles. Moreover, they will discover innovative methods that make it possible to control the exact connectivity of atoms within a molecule in order to set precise three-dimensional arrangements. Modern Tools for the Synthesis of Complex Bioactive Molecules features sixteen chapters, each one written by one or more leading experts in organic synthesis from around the world. It covers a broad range of topics that enable readers to take advantage of the latest methods for synthesizing complex molecules, including: Modern catalysis, emphasizing key transformations such as C-H functionalizations, cross-couplings, gold-catalyzed reactions, metathesis-based syntheses, and asymmetric organocatalysis Eco-compatible transformations, including rearrangements and domino reactions Tools for the synthesis of carbohydrates and alkaloids New techniques, including the use of fluorous tags and engineered biosynthesis The last two chapters explore target- and diversity-oriented organic synthesis as well as the use of DNA-based asymmetric catalysis, which are all promising tools for the successful synthesis of complex bioactive molecules. Modern Tools for the Synthesis of Complex Bioactive Molecules is ideal for students and researchers who need to plan and perform the synthesis of complex molecules as efficiently as possible. The book's expert advice will help these readers quickly resolve a broad range of problems that can arise in organic syntheses.

All the latest tools needed to plan and perform the synthesisof complex bioactive moleculesFocusing on organic, organometallic, and bio-oriented processesthis book explores the impact and use of the latest synthetic toolsfor the synthesis of complex biologically active compounds. Readerswill discover step by step how these synthetic tools have providednew, elegant solutions to many synthetic puzzles. Moreover, theywill discover innovative methods that make it possible to controlthe exact connectivity of atoms within a molecule in order to setprecise three-dimensional arrangements.Modern Tools for the Synthesis of Complex BioactiveMolecules features sixteen chapters, each one written by one ormore leading experts in organic synthesis from around the world. Itcovers a broad range of topics that enable readers to takeadvantage of the latest methods for synthesizing complex moleculesincluding:* Modern catalysis, emphasizing key transformations such as C-Hfunctionalizations, cross-couplings, gold-catalyzed reactionsmetathesis-based syntheses, and asymmetric organocatalysis* Eco-compatible transformations, including rearrangements anddomino reactions* Tools for the synthesis of carbohydrates and alkaloids* New techniques, including the use of fluorous tags andengineered biosynthesisThe last two chapters explore target- and diversity-orientedorganic synthesis as well as the use of DNA-based asymmetriccatalysis, which are all promising tools for the successfulsynthesis of complex bioactive molecules.Modern Tools for the Synthesis of Complex BioactiveMolecules is ideal for students and researchers who need toplan and perform the synthesis of complex molecules as efficientlyas possible. The book's expert advice will help these readersquickly resolve a broad range of problems that can arise in organicsyntheses.

FOREWORD viiPREFACE ixCONTRIBUTORS xiCHAPTER 1 C-H FUNCTIONALIZATION: A NEW STRATEGY FOR THESYNTHESIS OF BIOLOGICALLY ACTIVE NATURAL PRODUCTS 1Sophie Rousseaux, Benoy^t Lie´gault, and KeithFagnouCHAPTER 2 THE NEGISHI CROSS-COUPLING IN THE SYNTHESIS OF NATURALPRODUCTS AND BIOACTIVE MOLECULES 33Evelina Colacino, Jean Martinez, and Fre´de´ricLamatyCHAPTER 3 METAL-CATALYZED C-HETEROATOM CROSS-COUPLINGREACTIONS 77Renata Marcia de Figueiredo, Jean Marc Campagne, and DamienPrimCHAPTER 4 GOLDEN OPPORTUNITIES IN THE SYNTHESIS OF NATURALPRODUCTS AND BIOLOGICALLY ACTIVE COMPOUNDS 111Fabien GagoszCHAPTER 5 METATHESIS-BASED SYNTHESIS OF COMPLEX BIOACTIVES155Jean-Alexandre Richard, Sin Yee Ng, and David Y.-K. ChenCHAPTER 6 ENANTIOSELECTIVE ORGANOCATALYSIS: A POWERFUL TOOL FORTHE SYNTHESIS OF BIOACTIVE MOLECULES 189Mitsuru Shoji and Yujiro HayashiCHAPTER 7 ASYMMETRIC PHASE-TRANSFER CATALYSIS 213Seiji Shirakawa, Shin A. Moteki, and Keiji MaruokaCHAPTER 8 REARRANGEMENTS IN NATURAL PRODUCT SYNTHESIS 243Jose´ Marco-Contelles and Elena SorianoCHAPTER 9 DOMINO REACTIONS IN THE ENANTIOSELECTIVE SYNTHESIS OFBIOACTIVE NATURAL PRODUCTS 271Lutz F. Tietze, Scott G. Stewart, and AlexanderDu¨fertCHAPTER 10 FLUOROUS LINKER-FACILITATED SYNTHESIS OF BIOLOGICALLYINTERESTING MOLECULES 335Wei ZhangCHAPTER 11 THE EVOLUTION OF IMMOBILIZED REAGENTS AND THEIRAPPLICATION IN FLOW CHEMISTRY FOR THE SYNTHESIS OF NATURAL PRODUCTSAND PHARMACEUTICAL COMPOUNDS 359Rebecca M. Myers, Kimberley A. Roper, Ian R. Baxendale, andSteven V. LeyCHAPTER 12 SYNTHETIC APPROACHES TO BIOACTIVE CARBOHYDRATES395Xavier Guinchard, Se´bastien Picard, and DavidCrichCHAPTER 13 AMMONIUM YLIDES AS BUILDING BLOCKS FOR ALKALOIDSYNTHESIS 433Scott Bur and Albert PadwaCHAPTER 14 PRECURSOR-DIRECTED BIOSYNTHESIS OF POLYKETIDE ANDNONRIBOSOMAL PEPTIDE NATURAL PRODUCTS 485Colin J. B. Harvey and Chaitan KhoslaCHAPTER 15 TARGET-ORIENTED AND DIVERSITY-ORIENTED ORGANICSYNTHESIS 513Raphae¨l RodriguezCHAPTER 16 DNA AS A TOOL FOR MOLECULAR DISCOVERY 539Michael Smietana, Jean-Jacques Vasseur, Janine Cossy, andStellios ArseniyadisINDEX 557