The TNM Supplement, 4th Edition, includes new, detailed definitions of anatomical sites, regional lymph nodes, and TNM categories. It answers questions that frequently arise during daily use of the TNM system. Importantly, the TNM Supplement expands on the minimum requirements for pathological classification of individal tumour sites and enumerates the recommended criteria for each. Published in association with the Union for International Cancer Control, it provides oncologists with complementary material related to TNM staging not covered in TNM Classification of Malignant Tumours, 7th Edition.

The TNM Supplement, 4th Edition, includes new, detailed definitions of anatomical sites, regional lymph nodes, and TNM categories. It answers questions that frequently arise during daily use of the TNM system. Importantly, the TNM Supplement expands on the minimum requirements for pathological classification of individal tumour sites and enumerates the recommended criteria for each. Published in association with the Union for International Cancer Control, it provides oncologists with complementary material related to TNM staging not covered in TNM Classification of Malignant Tumours, 7th Edition.

Preface, viii
Organizations Associated with the TNM System, xiii

National Committees, xiii

Acknowledgements, xiv

Abbreviations, xv

Chapter 1 EXPLANATORY NOTES - GENERAL

The General Rules of the TNM System, 1

The TNM Clinical and Pathological Classifications, 6

Residual Tumour (R) Classification, 14

Additional Descriptors, 18

Unknown Primary, 22

Staging of Tumours for Which No TNM Classification is Provided,22

Histopathological Grading, 23

Chapter 2 EXPLANATORY NOTES - SPECIFIC ANATOMICALSITES

Head and Neck Tumours, 30

Lip and Oral Cavity, 37

Digestive System Tumours, 46

Lung and Pleural Tumours, 69

Bone Tumours, 81

Soft Tissue Tumours, 82

Skin Tumours, 83

Breast Tumours, 89

Gynaecological Tumours, 92

Urological Tumours, 101

Kidney, 105

Adrenal Cortex Tumours 109

Ophthalmic Tumours 110

Hodgkin Lymphoma and Non-Hodgkin Lymphomas, 116

Appendix, 118

Chapter 3 SITE-SPECIFIC REQUIREMENTS FOR pT AND pN

Introduction, 134

Head and Neck Tumours, 136

Digestive System Tumours, 142

Lung and Pleural Tumours, 148

Tumours of Bone and Soft Tissues, 150

Skin Tumours, 151

Breast Tumours, 154

Gynaecological Tumours, 156

Urological Tumours, 159

Adrenal Cortex Tumours, 164

Ophthalmic Tumours, 165

Hodgkin Lymphoma and Non-Hodgkin Lymphomas, 167

Chapter 4 NEW TNM CLASSIFICATIONS RECOMMENDED FORTESTING

Introduction, 171

General, 171

Specific, 171

Gastrointestinal Sarcomas (other than GISTs) (ICD-O C15-21),172

Malignant Thymic Epithelial Tumours (Thymoma) (ICD-O C37),174

Cranial and Facial Bones (ICD-O C41.0, 1), 174

Primary Cutaneous Lymphomas, 177

Cutaneous T-Cell Lymphoma (Excluding Lip, Eyelid, Vulva andPenis) (ICD-0 C44.2-7, C63.2), 177

ISLC/EORTC Revision to the Classification of Mycosis Fungoidesand Sézary Syndrome, 180

Chronic Myeloid Leukaemia, 182

Multiple Myeloma, 185

Primary Liver Carcinoma in Infants and Children/Hepatoblastoma,186

Adrenal Cortex Carcinoma, 188

Liver Metastasis of Colorectal Carcinoma, 188

Gastrointestinal Malignant Lymphomas, 189

Chapter 5 OPTIONAL PROPOSALS FOR TESTING NEW TELESCOPICRAMIFICATIONS OF TNM

All Tumour Sites, 193

Head and Neck Tumours, 193

Digestive System Tumours, 193

Liver, 196

Lung Tumours, 196

Tumours of Bone and Soft Tissues, 198

Gynaecological Tumours, 198

Urological Tumours, 199

Chapter 6 FREQUENTLY ASKED QUESTIONS

General Questions, 202

Site-Specific Questions, 211

Index, 243

Plate section facing p. 48