Practical Manual of Gastroesophageal Reflux Disease Edited by Marcelo F. Vela, Director of GI Motility, Gastroenterology Section, Baylor College of Medicine & Michael E. DeBakey VA Medical Center, Houston, TX, USA Joel E. Richter, Hugh Culverhouse Professor of Medicine, Director, Division of Gastroenterology and Nutrition, Director, Joy M. Culverhouse Center for Esophageal Diseases, University of South Florida, Tampa, FL, USA John E. Pandolfino, Department of Medicine, Division of Gastroenterology, Northwestern University, Chicago, IL, USA Do you regularly manage patients with GERD? Need a practical tool to guide you through best patient care and management? Highly practical, expertly-written, and packed with useful text tools like case histories, pitfall boxes and management algorithms, this convenient and user-friendly manual provides you with complete clinical guidance to gastroesophageal reflux disease (GERD), one of the most common conditions that gastroenterologists face every day. The book is divided into three parts: An overview of GERD, including pathophysiology, diagnosis, general management strategies and side effects from medical and surgical GERD therapies Management of specific clinical presentations such as Refractory GERD, Laryngopharyngeal Reflux, Noncardiac Chest Pain, and GERD-Related Dysphagia Barrett s Esophagus and GERD, including diagnosis, surveillance and treatment options With a strong focus on the clinical management of GERD and with contributions from the world s leading authorities on the topic, Practical Manual of Gastroesophageal Reflux Disease is the perfect tool for the modern day gastroenterologist - both at specialist level and in training managing this extremely prevalent condition.

Practical Manual of Gastroesophageal Reflux Disease Edited by Marcelo F. Vela, Director of GI Motility, Gastroenterology Section, Baylor College of Medicine & Michael E. DeBakey VA Medical Center, Houston, TX, USA Joel E. Richter, Hugh Culverhouse Professor of Medicine, Director, Division of Gastroenterology and Nutrition, Director, Joy M. Culverhouse Center for Esophageal Diseases, University of South Florida, Tampa, FL, USA John E. Pandolfino, Department of Medicine, Division of Gastroenterology, Northwestern University, Chicago, IL, USA Do you regularly manage patients with GERD? Need a practical tool to guide you through best patient care and management? Highly practical, expertly-written, and packed with useful text tools like case histories, pitfall boxes and management algorithms, this convenient and user-friendly manual provides you with complete clinical guidance to gastroesophageal reflux disease (GERD), one of the most common conditions that gastroenterologists face every day. The book is divided into three parts: An overview of GERD, including pathophysiology, diagnosis, general management strategies and side effects from medical and surgical GERD therapies Management of specific clinical presentations such as Refractory GERD, Laryngopharyngeal Reflux, Noncardiac Chest Pain, and GERD-Related Dysphagia Barrett s Esophagus and GERD, including diagnosis, surveillance and treatment options With a strong focus on the clinical management of GERD and with contributions from the world s leading authorities on the topic, Practical Manual of Gastroesophageal Reflux Disease is the perfect tool for the modern day gastroenterologist - both at specialist level and in training managing this extremely prevalent condition.

1;Practical Manual of Gastroesophageal Reflux Disease;51.1;Copyright;61.2;Contents;71.3;List of Contributors;91.4;Preface;111.5;Part 1 Gastroesophageal Reflux Disease Overview;131.5.1;Chapter 1 Gastroesophageal Reflux Disease: Pathophysiology;151.5.1.1;Introduction;151.5.1.2;Mechanisms leading to gastroesophageal reflux;161.5.1.3;Mechanisms involved in perception of reflux;251.5.1.4;Summary;301.5.1.5;References;311.5.2;Chapter 2 Gastroesophageal Reflux Disease: Epidemiology, Impact on Quality of Life, and Health Economic Implications;381.5.2.1;Introduction;391.5.2.2;Individual reflux syndromes;391.5.2.3;Epidemiology of gastroesophageal reflux disease;411.5.2.4;Health-related quality of life in gastroesophageal reflux disease;431.5.2.5;Health economic implications;451.5.2.6;Evolution and natural progression of gastroesophageal reflux disease;471.5.2.7;Summary;481.5.2.8;References;481.5.3;Chapter 3 Overview of the Tools for the Diagnosis of Gastroesophageal Reflux Disease;511.5.3.1;Introduction;511.5.3.2;Gastroesophageal reflux disease symptoms, questionnaires, and the proton pump inhibitor test;531.5.3.3;Esophagram and esophageal manometry;551.5.3.4;Endoscopy and esophageal biopsies;551.5.3.5;Ambulatory reflux monitoring;561.5.3.6;References;611.5.4;Chapter 4 Overview of Gastroesophageal Reflux Disease Treatments;651.5.4.1;Introduction;651.5.4.2;Lifestyle modifications;671.5.4.3;Acid suppression;681.5.4.4;Reflux inhibition;701.5.4.5;Enhancing acid clearance;701.5.4.6;Visceral hypersensitivity;721.5.4.7;Surgery and endoscopic treatment;731.5.4.8;Management algorithm;761.5.4.9;Conclusion;761.5.4.10;References;771.5.5;Chapter 5 Gastroesophageal Reflux Disease Treatment: Side-Effects and Complications of Acid Suppression;811.5.5.1;Introduction;821.5.5.2;Vitamin and mineral absorption effects;821.5.5.3;Alteration of pharmacokinetics/pharmacodynamics;861.5.5.4;Conclusion;911.5.5.5;References;921.5.6;Chapter 6 Gastroesophageal Reflux Disease Treatment: Side-Effects and Complications of Fundoplication;951.5.6.1;Introduction;961.5.6.2;General mortality, morbidity and conversion rate to open operation;971.5.6.3;Acute perioperative and immediate postoperative complications;981.5.6.4;Late postoperative complications;1001.5.6.5;Redo anti-reflux surgery;1031.5.6.6;References;1061.6;Part 2 Gastroesophageal Reflux Disease: Management of Specific Clinical Presentations;1091.6.1;Chapter 7 Evaluation and Management of Refractory Gastroesophageal Reflux Disease;1111.6.1.1;Introduction;1111.6.1.2;Definition of refractory gastroesophageal reflux disease and proton pump inhibitor non-responders;1121.6.1.3;Diagnostic algorithm for managing proton pump inhibitor non-responders;1171.6.1.4;Treatment of proton pump inhibitor non-responders;1201.6.1.5;Conclusion;1241.6.1.6;References;1241.6.2;Chapter 8 Functional Heartburn;1271.6.2.1;Introduction;1281.6.2.2;Definition and diagnostic criteria;1291.6.2.3;Pathogenesis of heartburn in functional heartburn;1321.6.2.4;Role of psychological factors;1361.6.2.5;Clinical evaluation;1361.6.2.6;Treatment;1371.6.2.7;References;1391.6.3;Chapter 9 The Role of Acid Reflux in Non-Cardiac Chest Pain;1441.6.3.1;Introduction;1451.6.3.2;Reflux in non-cardiac chest pain;1451.6.3.3;Mechanisms of pain;1471.6.3.4;Diagnosis;1501.6.3.5;Treatment;1561.6.3.6;Natural history and prognosis;1581.6.3.7;Summary and recommendations;1591.6.3.8;References;1601.6.4;Chapter 10 Laryngopharyngeal Reflux;1661.6.4.1;Introduction;1661.6.4.2;Prevalence;1671.6.4.3;Mechanisms of gastroesophageal reflux laryngitis;1681.6.4.4;Clinical symptoms;1691.6.4.5;Evaluation of the larynx;1691.6.4.6;Ambulatory pH studies;1721.6.4.7;Managing laryngeal complications of reflux disease;1781.6.4.8;Summary;1831.6.4.9;References;1851.6.5;Chapter 11 Reflux-Related Cough;1911.6.5.1;Introduction;1911.6.5.2;Epidemiology;1921.6.5.3;Pathophysiology;1921.6.5.4;Clinical management;1941.6