The content of this volume has been added to eMagRes (formerly Encyclopedia of Magnetic Resonance) - the ultimate online resource for NMR and MRI. The literature of multidimensional NMR began with the publication of three papers in 1975, then nine in 1976 and fifteen in 1977, and now contains many tens of thousands of papers. Any attempt to survey the field must therefore necessarily be very selective, not to say partial. In assembling this handbook, the Editors have sought to provide both the new researcher and the established scientist with a solid foundation for the understanding of multidimensional NMR, a representative if inevitably limited survey of its applications, an authoritative account of classic techniques such as COSY, NOESY and TOSCY, and an account of the latest progress in the development of multidimensional techniques. This handbook is structured in four parts. The first opens with an historical introduction to, and a brief account of, the practicalities and applications of multidimensional NMR methods, followed by a definitive survey of their conceptual basis and a series of articles setting out the generic principles of methods for acquiring and processing multidimensional NMR data. In the second part, the main families of multidimensional techniques, arranged in approximate order of increasing complexity, are described in detail, from simple J-resolved spectroscopy through to the powerful heteronuclear 3D and 4D methods that now dominate the study of structural biology in solution. The third part offers and illustrative selection from the very wide range of applications of multidimensional NMR methods, including some of the most recent developments in protein NMR. Finally, the fourth part introduces the idea of multidimensional spectra containing non-frequency dimensions, in which properties such as diffusion and relaxation are correlated. About EMR Handbooks / eMagRes Handbooks The Encyclopedia of Magnetic Resonance (up to 2012) and eMagRes (from 2013 onward) publish a wide range of online articles on all aspects of magnetic resonance in physics, chemistry, biology and medicine. The existence of this large number of articles, written by experts in various fields, is enabling the publication of a series of EMR Handbooks / eMagRes Handbooks on specific areas of NMR and MRI. The chapters of each of these handbooks will comprise a carefully chosen selection of articles from eMagRes. In consultation with the eMagRes Editorial Board, the EMR Handbooks / eMagRes Handbooks are coherently planned in advance by specially-selected Editors, and new articles are written (together with updates of some already existing articles) to give appropriate complete coverage. The handbooks are intended to be of value and interest to research students, postdoctoral fellows and other researchers learning about the scientific area in question and undertaking relevant experiments, whether in academia or industry. Have the content of this Handbook and the complete content of eMagRes at your fingertips! Visit: wileyonlinelibrary.com/ref/eMagRes View other eMagRes publications here

The content of this volume has been added toeMagRes (formerly Encyclopedia of MagneticResonance) - the href="onlinelibrary.wiley.com/book/10.1002/9780470034590/homepage/rf_coils_virtual_issue.htm?cm=on-chem&cs=chem-analytic&cu=sitename-ln&cd=sitename-In-MRIgroup-VI"target="_blank">ultimate online resource for NMR and MRI.The literature of multidimensional NMR began with thepublication of three papers in 1975, then nine in 1976 and fifteenin 1977, and now contains many tens of thousands of papers. Anyattempt to survey the field must therefore necessarily be veryselective, not to say partial. In assembling this handbook, theEditors have sought to provide both the new researcher and theestablished scientist with a solid foundation for the understandingof multidimensional NMR, a representative if inevitably limitedsurvey of its applications, an authoritative account of classictechniques such as COSY, NOESY and TOSCY, and an account of thelatest progress in the development of multidimensionaltechniques.This handbook is structured in four parts. The first opens withan historical introduction to, and a brief account of, thepracticalities and applications of multidimensional NMR methodsfollowed by a definitive survey of their conceptual basis and aseries of articles setting out the generic principles of methodsfor acquiring and processing multidimensional NMR data. In thesecond part, the main families of multidimensional techniquesarranged in approximate order of increasing complexity, aredescribed in detail, from simple J-resolved spectroscopy through tothe powerful heteronuclear 3D and 4D methods that now dominate thestudy of structural biology in solution. The third part offers andillustrative selection from the very wide range of applications ofmultidimensional NMR methods, including some of the most recentdevelopments in protein NMR. Finally, the fourth part introducesthe idea of multidimensional spectra containing non-frequencydimensions, in which properties such as diffusion and relaxationare correlated.About EMR Handbooks / eMagResHandbooksThe Encyclopedia of Magnetic Resonance (up to 2012) andeMagRes (from 2013 onward) publish a wide range of onlinearticles on all aspects of magnetic resonance in physicschemistry, biology and medicine. The existence of this large numberof articles, written by experts in various fields, is enabling thepublication of a series of EMR Handbooks / eMagResHandbooks on specific areas of NMR and MRI. Thechapters of each of these handbooks will comprise a carefullychosen selection of articles from eMagRes. In consultationwith the eMagRes Editorial Board, the EMRHandbooks / eMagRes Handbooks are coherentlyplanned in advance by specially-selected Editors, and new articlesare written (together with updates of some already existingarticles) to give appropriate complete coverage. The handbooks areintended to be of value and interest to research studentspostdoctoral fellows and other researchers learning about thescientific area in question and undertaking relevant experimentswhether in academia or industry.Have the content of this Handbook and the complete content ofeMagRes at your fingertips!Visit: href="wileyonlinelibrary.com/ref/eMagRes">wileyonlinelibrary.com/ref/eMagResView other eMagRes publications href="onlinelibrary.wiley.com/book/10.1002/9780470034590/homepage/emagres_publications.htm"target="_blank">here

Contributors.Series Preface.Volume Preface.Part A: Principles.1 Multidimensional NMR: an Introduction (Gareth A. MorrisJames W. Emsley).2 Multidimensional Spectroscopy: Concepts (Richard R.Ernst).3 Ultrafast Multidimensional NMR: Principles and Practice ofSingle-Scan Methods (Maayan Gal, Lucio Frydman).4 Fast Multidimensional NMR by Hadamard Spectroscopy (RayFreeman, Eriks Kupce).5 Multidimensional NMR by Projection-Reconstruction (RayFreeman, Eriks Kupce).6 Rapid Multidimensional NMR: Decomposition Methods and theirApplications (Martin Billeter, Doroteya K. Staykova).7 Multidimensional Correlation Spectroscopy by Covariance NMR(David A. Snyder, Rafael Bruschweiler).8 Maximum Entropy Methods in Multidimensional NMR (Jeffrey C.Hoch, Mehdi Mobli).9 Filter Diagonalization Methods for Time-Domain Signals (A.J. Shaka, Vladimir A. Mandelshtam).10 Fourier Transform and Linear Prediction Methods (Jens J.Led, Henrik Gesmar).Part B: Techniques.11 Two-Dimensional J-Resolved Spectroscopy (Gareth A.Morris).12 COSY (David M. Doddrell).13 COSY: Quantitative Analysis (Alex D. Bain).14 E.COSY: Determination of Coupling Constants (HaraldSchwalbe, P. Schmidt, Christian Griesinger).15 Relayed Coherence Transfer Experiments (Philip H.Bolton).16 TOCSY (Timothy D. W. Claridge).17 Multiple Quantum Spectroscopy of Liquid Samples (TimothyJ. Norwood).18 NOESY (Michael P. Williamson).19 ROESY (Ad Bax, Stephan Grzesiek).20 TOCSY in ROESY and ROESY in TOCSY (J. Schleucher, J.Quant, S. J. Glaser, Christian Griesinger).21 2D Methods of Monitoring Exchange (Keith G.Orrell).22 Heteronuclear Shift Correlation Spectroscopy (Thomas T.Nakashima, R. E. D. McClung).23 2D Methods for the Measurement of Long-RangeProton-Carbon Coupling Constants (Teodor Parella).24 Homonuclear 3D NMR of Biomolecules Rolf Boelens, RobertKaptein).25 3D HMQC-NOESY, NOESY-HMQC, and NOESY-HSQC (RanjithMuhandiram, Lewis E. Kay).26 3D and 4D Heteronuclear Magnetic Resonance (G. MariusClore, Angela M. Gronenborn).Part C: Applications.27 2D Carbon-Heteroelement Correlation (StefanBerger).28 Multidimensional NMR in Organotin Chemistry and Catalysis(Monique Biesemans, Rudolph Willem).29 2D NMR of Molecules Oriented in Liquid Crystalline Phases(Anil Kumar).30 2D NMR of Molecules Oriented in Liquid Crystals--RecentDevelopments (Anil Kumar, N. Suryaprakash).31 Local Field Experiments in Liquid Crystals (StefanoCaldarelli).32 Multiple Quantum Spectroscopy in Liquid Crystalline Solvents(Leslie D. Field).33 Biological Macromolecules: Structure Determination inSolution (Kurt W¨uthrich).34 Structures of Larger Proteins, Protein-Ligand, andProtein-DNA Complexes by Multidimensional Heteronuclear NMR(G. Marius Clore, Angela M. Gronenborn).35 Rapid Multidimensional NMR: Fast Pulsing Techniques and theirApplications to Proteins (Bernhard Brutscher, PaulSchanda).Part D: Related Techniques.36 Diffusion-Ordered Spectroscopy (Gareth A. Morris).37 2D Relaxometry (Brian P. Hills).Index.