Proton Transfer Reaction Mass Spectrometry (PTR-MS) is a rapidly growing analytical technique for detecting and identifying very small quantities of chemical compounds in air. It has seen widespread use in atmospheric monitoring and food science and shows increasing promise in applications such as industrial process monitoring, medical science and in crime and security scenarios. Written by leading researchers, this is the first book devoted to PTR-MS and it provides a comprehensive account of the basic principles, the experimental technique and various applications, thus making this book essential reading for researchers, technicians, postgraduate students and professionals in industry. The book contains nine chapters and is divided into two parts. The first part describes the underlying principles of the PTR-MS technique, including the relevant ion-molecule chemistry thermodynamics and reaction kinetics a discussion of ion sources, drift tubes and mass spectrometers practical aspects of PTR-MS, including calibration. The second part of the book turns its attention to some of the many applications of PTR-MS, demonstrating the scope and benefits, as well as the limitations, of the technique. The chapters that make up the second part of the book build upon the material presented in the first part and are essentially self-contained reviews focusing on the following topics: environmental science food science medicine homeland security, and applications of PTR-MS in liquid analysis.

Proton Transfer Reaction Mass Spectrometry (PTR-MS) is a rapidlygrowing analytical technique for detecting and identifying verysmall quantities of chemical compounds in air. It has seenwidespread use in atmospheric monitoring and food science and showsincreasing promise in applications such as industrial processmonitoring, medical science and in crime and securityscenarios.Written by leading researchers, this is the first book devoted toPTR-MS and it provides a comprehensive account of the basicprinciples, the experimental technique and various applicationsthus making this book essential reading for researcherstechnicians, postgraduate students and professionals inindustry.The book contains nine chapters and is divided into two parts.The first part describes the underlying principles of the PTR-MStechnique, including* the relevant ion-molecule chemistry* thermodynamics and reaction kinetics* a discussion of ion sources, drift tubes and massspectrometers* practical aspects of PTR-MS, includingcalibration.The second part of the book turns its attention to some of themany applications of PTR-MS, demonstrating the scope and benefitsas well as the limitations, of the technique. The chapters thatmake up the second part of the book build upon the materialpresented in the first part and are essentially self-containedreviews focusing on the following topics:* environmental science* food science* medicine* homeland security, and* applications of PTR-MS in liquid analysis.

Quotation xiiiPreface xvSECTION 1 FUNDAMENTALS1 Background 31.1 Volatile Organic Compounds in the Earth's Atmosphere31.2 Volatile Organic Compounds in Other Environments 51.3 Techniques for VOC Measurements 61.4 Emergence of Proton Transfer Reaction Mass Spectrometry15References 232 Chemical Ionization: Chemistry, Thermodynamics and Kinetics252.1 Introduction 252.2 Proton Transfer 272.3 Other Chemical Ionization Processes 44References 453 Experimental: Components and Principles 493.1 Introduction 493.2 Ion Extraction and Ion Optics 503.3 Ion Sources 573.4 Drift Tubes 643.5 Mass Spectrometry 763.6 Ion Detectors 973.7 Analogue versus Digital Signal Processing 103References 1064 Quantitative Analysis 1114.1 Introduction 1114.2 Extracting the Concentration of a Trace Gas from PTR-MS1114.3 Normalized Counts per Second 1124.4 Why Calibrate? 1134.5 Calibration Techniques 1164.6 Effect of Humidity 1204.7 Accuracy, Precision and Limit of Detection 1224.8 Validation of PTR-MS 125References 126SECTION 2 APPLICATIONS5 PTR-MS in the Environmental Sciences 1315.1 Background 1315.2 Use of Reagent Ions Other Than H3O+ 1385.3 Biogenic VOCs 1415.4 Anthropogenic VOCs 1565.5 Biomass Burning 1665.6 Applications of PTR-MS to Laboratory Studies of AtmosphericChemistry 1695.7 Plant Studies 1785.8 Outlook for Atmospheric and Environmental Applications ofPTR-MS 201References 2016 PTR-MS in the Food Sciences 2196.1 Background 2196.2 Combined GC-MS and PTR-MS Studies for Food Analysis2216.3 Mass Spectral Fingerprinting 2246.4 Flavour Release and Perception 2256.5 Food Classification, Food Quality and Food Control 2436.6 Outlook for Food Science and Technology Applications 254References 2557 PTR-MS in the Medical Sciences 2657.1 Background 2657.2 Breath Analysis 2667.3 Online PTR-MS Measurements of Volatile Emissions fromMicrobial Cultures 2887.4 Other Medical Applications 295References 3008 Applications of PTR-MS to Homeland Security: The Detectionof Threat Agents 3098.1 Background 3098.2 Explosives 3108.3 Chemical Warfare Agents and Toxic Industrial Chemicals3198.4 Narcotics 3208.5 Date Rape Drugs 3238.6 Ion Mobility Mass Spectrometry and PTR-MS: A BriefComparison for Homeland Security Applications 3248.7 Future Directions 325References 3269 Liquid Analysis Using PTR-MS 3299.1 Determination of Henry's Law Constants Using PTR-MS3299.2 Analysis of Liquids 331References 334Index