Bioactive compounds play a central role in high-value product development in the chemical industry. Bioactive compounds have been identified from diverse sources and their therapeutic benefits, nutritional value and protective effects in human and animal healthcare have underpinned their application as pharmaceuticals and functional food ingredients. The orderly study of biologically active products and the exploration of potential biological activities of these secondary metabolites, including their clinical applications, standardization, quality control, mode of action and potential biomolecular interactions, has emerged as one of the most exciting developments in modern natural medicine. Biotechnology of Bioactive Compounds describes the current stage of knowledge on the production of bioactive compounds from microbial, algal and vegetable sources. In addition, the molecular approach for screening bioactive compounds is also discussed, as well as examples of applications of these compounds on human health. The first half of the book comprises information on diverse sources of bioactive compounds, ranging from microorganisms and algae to plants and dietary foods. The second half of the book reviews synthetic approaches, as well as selected bioactivities and biotechnological and biomedical potential. The bioactive compounds profiled include compounds such as C-phycocyanins, glycosides, phytosterols and natural steroids. An overview of the usage of bioactive compounds as antioxidants and anti-inflammatory agents, anti-allergic compounds and in stem cell research is also presented, along with an overview of the medicinal applications of plant-derived compounds. Biotechnology of Bioactive Compounds will be an informative text for undergraduate and graduate students of bio-medicinal chemistry who are keen to explore the potential of bioactive natural products. It also provides useful information for scientists working in various research fields where natural products have a primary role.

Bioactive compounds play a central role in high-value product development in the chemical industry. Bioactive compounds have been identified from diverse sources and their therapeutic benefits, nutritional value and protective effects in human and animal healthcare have underpinned their application as pharmaceuticals and functional food ingredients. The orderly study of biologically active products and the exploration of potential biological activities of these secondary metabolites, including their clinical applications, standardization, quality control, mode of action and potential biomolecular interactions, has emerged as one of the most exciting developments in modern natural medicine.Biotechnology of Bioactive Compounds describes the current stage of knowledge on the production of bioactive compounds from microbial, algal and vegetable sources. In addition, the molecular approach for screening bioactive compounds is also discussed, as well as examples of applications of these compounds on human health. The first half of the book comprises information on diverse sources of bioactive compounds, ranging from microorganisms and algae to plants and dietary foods. The second half of the book reviews synthetic approaches, as well as selected bioactivities and biotechnological and biomedical potential. The bioactive compounds profiled include compounds such as C-phycocyanins, glycosides, phytosterols and natural steroids. An overview of the usage of bioactive compounds as antioxidants and anti-inflammatory agents, anti-allergic compounds and in stem cell research is also presented, along with an overview of the medicinal applications of plant-derived compounds.Biotechnology of Bioactive Compounds will be an informative text for undergraduate and graduate students of bio-medicinal chemistry who are keen to explore the potential of bioactive natural products. It also provides useful information for scientists working in various research fields where natural products have a primary role.

List of contributors ixForeword xviiPreface xixSection I: Bioactive compounds from diverse plant microbial and marine sources1 Bioactive compounds from vegetable and fruit by-products 3B. De Ancos C. Colina-Coca D. González-Pena and C. Sánchez-Moreno2 Bioactive compounds in fresh-cut fruits: Occurrence and impact of processing and cold storage 37María Elida Pirovani Andrea Marcela Piagentini and Franco Van de Velde3 Pressurized hot water extraction of polyphenols from plant material 63José Rodrigo Vergara-Salinas José Cuevas-Valenzuela and José R. Pérez-Correa4 Bioactive compounds in cereals: Technological and nutritional properties 103Bart³omiej Makowski Justyna Rosicka-Kaczmarek and Ewa Nebesny5 Antimicrobials from medicinal plants: Research initiatives challenges and the future prospects 123Anita Pandey and Vasudha Agnihotri6 Coccoloba uvifera as a source of components with antioxidant activity 151Maira Segura Campos Jorge Ruiz Ruiz Luis Chel Guerrero and David Betancur Ancona7 Bioactive compounds and medical significance of some endangered medicinal plants from the Western Ghats region of India 163Manoharan Melvin Joe Abitha Benson Muniappan Ayyanar and Tongmin Sa8 Fungal bioactive compounds: An overview 195Gerardo Díaz-Godínez9 Arbuscular mycorrhizal fungi: Association and production of bioactive compounds in plants 225Marcela C. Pagano and Partha P. Dhar10 Extremophiles as source of novel bioactive compounds with industrial potential 245Mohamed Neifar Sameh Maktouf Raoudha Ellouze Ghorbel Atef Jaouani and Ameur Cherif11 New trends in microbial production of natural complex bioactive isoprenoids 269Rama Raju Baadhe Ravichandra Potumarthi Naveen Kumar Mekala and Vijai K. Gupta12 Production of c-phycocyanin and its potential applications 283Mohammed Kuddus Poonam Singh George Thomas and Athar AliSection II: Chemistry biotechnology and industrial relevance13 Glycosides: From biosynthesis to biological activity toward therapeutic application 303Maria Henriques L. Ribeiro14 Trehalose mimics as bioactive compounds 345Davide Bini Antonella Sgambato Luca Gabrielli Laura Russo and Laura Cipolla15 Virtual screening and prediction of the molecular mechanism of bioactive compounds in silico 371Bashir A. Akhoon Krishna P. Singh Madhumita Karmakar Suchi Smita Rakesh Pandey and Shailendra K. Gupta16 Steroids in natural matrices: Chemical features and bioactive properties 395Joao C.M. Barreira and Isabel C.F.R. Ferreira17 Bioactive compounds obtained through biotechnology 433Gustavo Molina Franciele M. Pelissari Marina G. Pessoa and Gláucia M. Pastore18 Metabolic engineering of bioactive compounds in berries 463Ivayla Dincheva Ilian Badjakov and Violeta Kondakova19 Food-derived multifunctional bioactive proteins and peptides: Sources and production 483Dominic Agyei Ravichandra Potumarthi and Michael K. Danquah20 Food-derived multifunctional bioactive proteins and peptides: Applications and recent advances 507Dominic Agyei Ravichandra Potumarthi and Michael K. DanquahSection III: Biochemistry and nutraceutical or health-related applications21 An overview of the molecular and cellular interactions of some bioactive compounds 527Amro Abd Al Fattah Amara22 Bioactive compounds as growth factors and 3D matrix materials in stem cell research 555Naveen Kumar Mekala Rama Raju Baadhe and Ravichandra Potumarthi23 Phytosterols: Biological effects and mechanisms of hypocholesterolemic action 565Rafaela da Silva Marineli Cibele Priscila Busch Furlan Anne y Castro Marques Juliano Bicas Gláucia Maria Pastore and Mário Roberto Maróstica Jr.24 Overview of the role of food bioactive compounds as complementary therapy for celiac disease 583Antonio Cilla Laia Alemany Juan Antonio Giménez and José Moisés Laparra25 Bioactive lipid components from ruminant milk and meat: The new face of human health 599Malgorzata Szumacher-Strabel Mohamed El-Sherbiny Adam Cieslak Joanna Szczechowiak and Hanna Winiarska26 The milk fat globule membrane: A potential source of health-promoting glycans 631Sarah A. Ross Jonathan A. Lane Michelle Kilcoyne Lokesh Joshi and Rita M. Hickey27 Seaweed and milk derived bioactive peptides and small molecules in functional foods and cosmeceuticals 669Maria Hayes Melani García-García Ciarán Fitzgerald and Tomas LafargaIndex 693