A new perspective on the link between inflammation and cancer Inflammation is the human body s normal biological response to threats in the modern world, as well as a defense against the harmful influence of pathogens, the environment, and poor nutrition. But what happens when the inflammatory response is triggered repeatedly and sustained for long periods of time? Cancer and Inflammation Mechanisms: Chemical, Biological, and Clinical Aspects discusses the mechanisms by which chronic inflammation can lead to cancer, the various causative agents, and possible prevention methods. A compilation of the latest information coming out of the various fields of cancer research, this book provides a detailed look at inflammation-related carcinogenesis from the perspective of researchers at the forefront of the field. It takes an interdisciplinary approach to the topic, and provides comprehensive information about the major factors at work in inflammation, cancer, and the intersection of the two conditions. Topics include: A general overview of inflammation-related cancer The biochemistry of inflammation and its effects on DNA Molecular biology and the role of microRNA in carcinogenesis Specific causative agents including oncogenic viruses, asbestos, and nanomaterial Anti-inflammatories, nutraceuticals, and other preventative measures A deeper understanding of the mechanisms behind inflammation-related carcinogenesis can lead to better patient outcomes by improving diagnostics and prevention, as well as altering the approach to treatment. Cancer and Inflammation Mechanisms: Chemical, Biological, and Clinical Aspects provides the knowledge base researchers need to push the field forward.

A new perspective on the link between inflammation andcancerInflammation is the human body's normal biologicalresponse to threats in the modern world, as well as a defenseagainst the harmful influence of pathogens, the environment, andpoor nutrition. But what happens when the inflammatory response istriggered repeatedly and sustained for long periods of time?Cancer and Inflammation Mechanisms: Chemical, Biological, andClinical Aspects discusses the mechanisms by which chronicinflammation can lead to cancer, the various causative agents, andpossible prevention methods.A compilation of the latest information coming out of thevarious fields of cancer research, this book provides a detailedlook at inflammation-related carcinogenesis from the perspective ofresearchers at the forefront of the field. It takes aninterdisciplinary approach to the topic, and provides comprehensiveinformation about the major factors at work in inflammationcancer, and the intersection of the two conditions. Topicsinclude:* A general overview of inflammation-related cancer* The biochemistry of inflammation and its effects on DNA* Molecular biology and the role of microRNA incarcinogenesis* Specific causative agents including oncogenic virusesasbestos, and nanomaterial* Anti-inflammatories, nutraceuticals, and other preventativemeasuresA deeper understanding of the mechanisms behindinflammation-related carcinogenesis can lead to better patientoutcomes by improving diagnostics and prevention, as well asaltering the approach to treatment. Cancer and InflammationMechanisms: Chemical, Biological, and Clinical Aspects providesthe knowledge base researchers need to push the field forward.

CONTRIBUTORS ixPREFACE xvSECTION I GENERAL OVERVIEW OF INFLAMMATION-RELATEDCANCERCHAPTER 1 INFECTION, INFLAMMATION, AND CANCER: OVERVIEW 1Hiroshi Ohshima, Noriyuki Miyoshi, and Susumu TomonoCHAPTER 2 STEM CELL THEORY AND INFLAMMATION-RELATED CANCER9Toshihiko Tanno and William MatsuiCHAPTER 3 EPITHELIAL-MESENCHYMAL TRANSITION: A LINKBETWEEN CANCER AND INFLAMMATION 23Jonas Fuxe and Mikael C. I. KarlssonSECTION II BIOCHEMISTRY IN INFLAMMATION-RELATEDCANCERCHAPTER 4 ROLE OF NITRATIVE DNA DAMAGE IN INFLAMMATION RELATEDCARCINOGENESIS 41Yusuke Hiraku and Shosuke KawanishiCHAPTER 5 LIPID PEROXIDATION-DERIVED DNA ADDUCTS AND THEROLE IN INFLAMMATION-RELATED CARCINOGENESIS 61Helmut Bartsch and Urmila Jagadeesan NairCHAPTER 6 LEVEL OF INFLAMMATION-RELATED DNA ADDUCTS IN HUMANTISSUES 75Tomonari Matsuda, Pei-Hsin Chou, and Haruhiko SugimuraSECTION III MOLECULAR BIOLOGY IN INFLAMMATION-RELATEDCANCERCHAPTER 7 TOLL-LIKE RECEPTORS: ROLE IN INFLAMMATION AND CANCER83Sarang Tartey and Osamu TakeuchiCHAPTER 8 INFLAMMASOMES AND INFLAMMATION 103Kaiwen W. Chen, Ayanthi A. Richards, Alina Zamoshnikova, andKate SchroderCHAPTER 9 ACTIVATION-INDUCED CYTIDINE DEAMINASE: AN INTRINSICGENOME MODULATOR IN INFLAMMATION-ASSOCIATED CANCER DEVELOPMENT119Hiroyuki Marusawa and Tsutomu ChibaCHAPTER 10 MicroRNA AND INFLAMMATION-RELATED CANCER 131Zhaojian Gong, Zhaoyang Zeng, Pranab Behari Mazumder, Jian MaMing Zhou, Xiayu Li, Xiaoling Li, Wei Xiong, Yong Li, and GuiyuanLiCHAPTER 11 INFLAMMATION AS A NICHE FOR TUMOR PROGRESSION149Futoshi OkadaSECTION IV INFLAMMATION-RELATED CANCER INDUCED BY SPECIFICCAUSESCHAPTER 12 HUMAN PAPILLOMAVIRUS AND CERVICAL CANCER 165Kurt J. SalesCHAPTER 13 HEPATITIS VIRUSES AND HEPATOCELLULAR CARCINOMA181Wai-Kay Seto, Ching-Lung Lai, and Man-Fung YuenCHAPTER 14 EPSTEIN-BARR VIRUS AND NASOPHARYNGEAL CARCINOMA193Xiaoying Zhou, Xue Xiao, Fu Chen, Tingting Huang, and ZheZhangCHAPTER 15 BARRETT'S ESOPHAGUS AND ESOPHAGEAL CANCER213Albert Roessner and Angela PoehlmannCHAPTER 16 ASBESTOS-INDUCED CHRONIC INFLAMMATION AND CANCER223Andrea Napolitano, Sandro Jube, Giovanni Gaudino, Harvey I.Pass, Michele Carbone, and Haining YangCHAPTER 17 NANOMATERIALS 235Yiqun Mo, Rong Wan, David J. Tollerud, and Qunwei ZhangCHAPTER 18 INFLAMMATORY PATHWAYS OF RADIATION-INDUCED TISSUEINJURY 249Danae A. Laskaratou, Ifigeneia V. Mavragani, and Alexandros G.GeorgakilasCHAPTER 19 PHOTOCARCINOGENESIS AND INFLAMMATION 271Chikako NishigoriSECTION V. PREVENTION OF INFLAMMATION-RELATEDCARCINOGENESISCHAPTER 20 CHEMOPREVENTION OF COLORECTAL CANCER BYANTI-INFLAMMATORY AGENTS 285Michihiro Mutoh, Mami Takahashi, and Keiji WakabayashiCHAPTER 21 NUTRACEUTICALS AND COLON CANCER PREVENTION 301Deepak Poudyal and Lorne J. HofsethCHAPTER 22 CANCER CHEMOPREVENTION BY TARGETING COX-2 USINGDIETARY PHYTOCHEMICALS 339Kyung-Soo Chun and Young-Joon SurhCHAPTER 23 REGULATION OF INFLAMMATION-ASSOCIATED INTESTINALDISEASES WITH PHYTOCHEMICALS 355Akira MurakamiINDEX 371