A fully updated and expanded edition of the bestselling guide on toxicology and its practical application Covers the diverse chemical hazards encountered in the modern work and natural environment, and provides a practical understanding of these hazards New chapters cover the emerging areas of toxicology such as omics, computational toxicology, and nanotoxicology Provides clear explanations and practical understanding of the fundamentals necessary for an understanding of the effects of chemical hazards on human health and ecosystems Includes case histories and examples from industry demonstrate the application of toxicological principles Supplemented with numerous illustrations to clarify and summarize key points, annotated bibliographies, and a comprehensive glossary of toxicological terms

A fully updated and expanded edition of the bestselling guide ontoxicology and its practical application* Covers the diverse chemical hazards encountered in themodern work and natural environment, and provides a practicalunderstanding of these hazards* New chapters cover the emerging areas of toxicologysuch as omics, computational toxicology, and nanotoxicology* Provides clear explanations and practicalunderstanding of the fundamentals necessary for an understanding ofthe effects of chemical hazards on human health andecosystems* Includes case histories and examples from industrydemonstrate the application of toxicological principles* Supplemented with numerous illustrations to clarifyand summarize key points, annotated bibliographies, and acomprehensive glossary of toxicological terms

Contributors viiPreface ix1 General Principles of Toxicology 1Robert C. James, Stephen M. Roberts, and Phillip L.Williams2 Xenobiotic Absorption, Distribution, Metabolism, and Excretion29Michael R. Franklin3 Toxicokinetics 59Rebecca A. Clewell and Harvey J. Clewell III4 Omics Technologies in Toxicology 89Mary Jane Cunningham5 Toxicity of the Hematopoietic System 103Sherilyn A. Gross6 Hepatotoxicity: Toxic Effects on the Liver 125Robert C. James and Stephen M. Roberts7 Nephrotoxicity: Toxic Responses of the Kidney 139Lawrence H. Lash8 Neurotoxicity: Toxic Effects on the Nervous System 157William M. Caudle and Gary W. Miller9 Dermatotoxicity: Toxic Effects on the Skin 169Sailesh Konda and Howard I. Maibach10 Pulmonotoxicity: Toxic Effects in the Lung 179Cuiqing Liu and Qinghua Sun11 Immunotoxicity: Toxic Effects on the Immune System 197Eric S. Sobel and Stephen M. Roberts12 Toxic Effects on Reproduction 211Mary L. Hixon13 Developmental Toxicology 223Vincent F. Garry and Peter L. Truran14 Mutagenesis and Genetic Toxicology 235Martha M. Moore, Meagan B. Myers, and Robert H. Heflich15 Chemical Carcinogenesis 259James E. Klaunig16 Properties and Effects of Metals 283David B. Mayfield, Ari S. Lewis, Lisa A. Bailey, and Barbara D.Beck17 Properties and Effects of Pesticides 309Janice Britt18 Properties and Effects of Solvents and Solvent-Like Chemicals325Christopher M. Teaf, Michele M. Garber, and J. MichaelKuperberg19 Nanotoxicology 359Hongbo Ma, Steve Diamond, Georgia Hinkley, and Stephen M.Roberts20 Computational Toxicology 373Richard S. Judson, David M. Reif, and Keith A. Houck21 E pidemiological Issues in Occupational and EnvironmentalHealth 391Michael S. Bloom and John E. Vena22 Occupational and Environmental Health 411Brenda S. Buikema, T. Renée Anthony, and FredricGerr23 Human Health Risk Assessment 425Leah D. Stuchal, Robert C. James, and Stephen M. RobertsGlossary 457Index 471