Provides coverage of the pathogenesis, clinical, morphologic, molecular and investigational aspects of a full range of blood disorders seen in daily practice The revised fifth edition of this renowned atlas presents readers with a comprehensive, visual guide to clinical hematology, featuring 2700 full-color photographs and figures depicting the spectrum of hematological diseases. Ranging from photographs of the clinical manifestations and key microscopic findings to diagrams of the molecular aspects of these diseases, the book provides up-to-date information of the blood diseases that clinicians encounter every day. Color Atlas of Clinical Hematology: Molecular and Cellular Basis of Disease offers the reader an understanding of normal cell machinery, and of the molecular basis for such processes as DNA and cell replication, RNA species, trafficking and splicing, protein synthesis, transcription factors, growth factor signal transduction, epigenetics, cell differentiation, autophagy, and apoptosis. The text goes on to explore how these processes are disturbed in the various diseases of the bone marrow, blood, and lymphoid systems. Helps solve difficult diagnostic challenges and covers complex principles using highly illustrative, full-color images Explores all aspects of benign and malignant hematology, including blood transfusion and coagulation with extensive coverage of the pathogenesis of common clinical entities Provides a quick and easy reference of key diagnostic issues in a comprehensive yet concise format Includes and illustrates the WHO Classification of Hematologic Malignancies Illustrates the new knowledge of the molecular basis of inherited and acquired blood diseases Color Atlas of Clinical Hematology: Molecular and Cellular Basis of Disease is the must-have resource for both trainee and practising hematologists, and for every department of hematology."e;Substantially updated and now multi-authored so that all aspects of haematology are equally covered, including the newest developments in molecular biology and genomic sequencing"e;"e;There is a surplus of invention in communicating complex problems here and an admirable effort to keep the reader totally up-to-date"e;

Provides coverage of the pathogenesis, clinical, morphologic, molecular and investigational aspects of a full range of blood disorders seen in daily practiceThe revised fifth edition of this renowned atlas presents readers with a comprehensive, visual guide to clinical hematology, featuring 2700 full-color photographs and figures depicting the spectrum of hematological diseases. Ranging from photographs of the clinical manifestations and key microscopic findings to diagrams of the molecular aspects of these diseases, the book provides up-to-date information of the blood diseases that clinicians encounter every day.Color Atlas of Clinical Hematology: Molecular and Cellular Basis of Disease offers the reader an understanding of normal cell machinery, and of the molecular basis for such processes as DNA and cell replication, RNA species, trafficking and splicing, protein synthesis, transcription factors, growth factor signal transduction, epigenetics, cell differentiation, autophagy, and apoptosis. The text goes on to explore how these processes are disturbed in the various diseases of the bone marrow, blood, and lymphoid systems.* Helps solve difficult diagnostic challenges and covers complex principles using highly illustrative, full-color images* Explores all aspects of benign and malignant hematology, including blood transfusion and coagulation with extensive coverage of the pathogenesis of common clinical entities* Provides a quick and easy reference of key diagnostic issues in a comprehensive yet concise format* Includes and illustrates the WHO Classification of Hematologic Malignancies* Illustrates the new knowledge of the molecular basis of inherited and acquired blood diseasesColor Atlas of Clinical Hematology: Molecular and Cellular Basis of Disease is the must-have resource for both trainee and practising hematologists, and for every department of hematology."Substantially updated and now multi-authored so that all aspects of haematology are equally covered, including the newest developments in molecular biology and genomic sequencing""There is a surplus of invention in communicating complex problems here and an admirable effort to keep the reader totally up-to-date"

Preface xxx1 Molecular Biology of the Cell2 Hematopoiesis3 Growth Factor Signaling4 Erythropoiesis and Examination of the Peripheral Blood and Bone Marrow5 Hypochromic Anemias6 The Porphyrias and Iron Overload7 Megaloblastic Anemias8 Hemolytic Anemias9 Genetic Disorders of Hemoglobin10 Benign Disorders of Phagocytes11 Benign Disorders of Lymphocytes and Plasma Cells12 Aplastic and Dyserythropoietic Anemias13 The Hematologic Neoplasms: Laboratory Techniques and Acute Myeloid Leukemia14 Acute Lymphoblastic Leukemia15 Myelodysplastic Syndromes16 Myeloproliferative Neoplasms17 Mastocytosis, Myeloid/Lymphoid Neoplasms with Eosinophilia and Specific Cytogenetic Rearrangements, Myelodysplastic/Myeloproliferative Neoplasms18 Chronic Lymphocytic Leukemia and Other Mature B- and T/Nk-Cell Leukemias19 Small B-Cell Lymphomas20 Aggressive Mature B-Cell Neoplasms21 Myeloma and Related Neoplasms22 Peripheral T- and NK-Cell Neoplasms23 Hodgkin Lymphoma24 Histiocytic Disorders25 Stem Cell Transplantation26 Normal Hemostasis, Platelet Production and Function27 Vascular and Platelet Bleeding Disorders28 Inherited and Acquired Coagulation Disorders29 Thrombosis and Antithrombotic Therapy30 Hematologic Aspects of Systemic Diseases31 Parasitic Disorders32 Blood TransfusionAppendix 1 2016 World Health Organization Classification of Lymphoid and Myeloid NeoplasmsIndex xxx