Drug Disposition and Pharmacokinetics The most up-to-date edition of a leading reference in drug disposition and pharmacokinetics In this new, fully-revised edition of Drug Disposition and Pharmacokinetics: Principles and Applications for Medicine, Toxicology and Biotechnology the authors deliver an authoritative and comprehensive discussion of the fate of drug molecules in the body, as well as its implications for pharmacological and clinical effects. The text offers a unique and balanced approach that combines discussion of the specific physical and biological factors affecting the absorption, distribution, metabolism, and excretion of drugs, with mathematical assessments of plasma and body fluid concentrations. The book assumes little prior knowledge and is an ideal reference for practicing professionals in industry as well as researchers and academics. This latest edition provides readers with a new introductory chapter, as well as new chapters covering monoclonal antibodies, the role of stereochemistry in drug disposition and pharmacokinetics, DMPK in non-human species, and the recent use of AI in drug development. Readers will also find: Thorough introductions to drug disposition, pharmacokinetics, and pharmacokinetic modeling In-depth treatments of the kinetics of drug elimination and the relationship between concentration and effect, including PK PD modeling Comprehensive discussions of predictive pharmacokinetics and the disposition of biological molecules, including peptides and monoclonal antibodies Detailed examinations of the effects of sex, pregnancy, age, and disease, as well as drug monitoring in therapeutics and the use of AI in drug development and treatment Perfect for professionals and researchers working with the scientific aspects of drug disposition in human and veterinary medicine, toxicology, and pharmacology. Drug Disposition and Pharmacokinetics will earn a place in the libraries of students of senior-level courses in pharmacy.

Drug Disposition and PharmacokineticsThe most up-to-date edition of a leading reference in drug disposition and pharmacokineticsIn this new, fully-revised edition of Drug Disposition and Pharmacokinetics: Principles and Applications for Medicine, Toxicology and Biotechnology the authors deliver an authoritative and comprehensive discussion of the fate of drug molecules in the body, as well as its implications for pharmacological and clinical effects. The text offers a unique and balanced approach that combines discussion of the specific physical and biological factors affecting the absorption, distribution, metabolism, and excretion of drugs, with mathematical assessments of plasma and body fluid concentrations. The book assumes little prior knowledge and is an ideal reference for practicing professionals in industry as well as researchers and academics.This latest edition provides readers with a new introductory chapter, as well as new chapters covering monoclonal antibodies, the role of stereochemistry in drug disposition and pharmacokinetics, DMPK in non-human species, and the recent use of AI in drug development. Readers will also find:* Thorough introductions to drug disposition, pharmacokinetics, and pharmacokinetic modeling* In-depth treatments of the kinetics of drug elimination and the relationship between concentration and effect, including PK-PD modeling* Comprehensive discussions of predictive pharmacokinetics and the disposition of biological molecules, including peptides and monoclonal antibodies* Detailed examinations of the effects of sex, pregnancy, age, and disease, as well as drug monitoring in therapeutics and the use of AI in drug development and treatmentPerfect for professionals and researchers working with the scientific aspects of drug disposition in human and veterinary medicine, toxicology, and pharmacology. Drug Disposition and Pharmacokinetics will earn a place in the libraries of students of senior-level courses in pharmacy.

Preface1 Setting the Scene: Concepts, Nature of Drugs and Quality of Results2 Drug Disposition and Fate3 Pharmacokinetic Modelling4 Pharmacokinetics of Metabolism and Excretion5 Quantitative Pharmacological Relationships6 Predictive Pharmacokinetics7 Disposition of Peptides and Other Biological Molecules8 Monoclonal Antibodies9 Drug Metabolism and Pharmacokinetics in Veterinary Sciences10 Factors Affecting Plasma Concentrations. Consideration of Special Populations.11 Pharmacogenetics, Pharmacogenomics and Precision Medicine12 Effects of Sex and Pregnancy on Drug Disposition and Pharmacokinetics13 Developmental Pharmacology and Age-related Phenomena14 Effects of Disease on Drug Disposition and Pharmacokinetics15 Role of Stereochemistry in Drug Disposition and Pharmacokinetics16 Drug Metabolism and Pharmacokinetics in Drug Interactions and Toxicity17 Drug Monitoring in Therapeutics18 From Antiquity to the Age of Artificial Intelligence: Reflections on the Past, Present and Future of Drug Disposition and PharmacokineticsIndex