Nucleic Acids in Medicinal Chemistry and Chemical Biology An up-to-date and comprehensive exploration of nucleic acid medicinal chemistry and its applications In Nucleic Acids in Medicinal Chemistry and Chemical Biology: Drug Development and Clinical Applications, a team of distinguished researchers delivers a comprehensive overview of the chemistry and biology of nucleic acids and their therapeutic applications. The book emphasizes the latest research in the field, including new technologies like CRISPR that create novel possibilities to edit mutated genes at the genomic DNA level and to treat inherited diseases and cancers. The authors explore the application of modified nucleosides and nucleotides in medicinal chemistry, a variety of current topics on nucleic acid chemistry and biology, nucleic acid drugs used to treat disease, and more. They also probe new domains of pharmaceutical research, offering the reader a wealth of new drug discovery opportunities emerging in this dynamic field. Readers will also find: A thorough introduction to the basic terminology and knowledge of the field of nucleic acid medicinal chemistry Comprehensive explorations of the methods used to determine the development of nucleic acid drugs Practical discussions of new technologies, like CRISPR, nanotechnology-based delivery systems, synthetic biology, and DNA-encoded chemical libraries In-depth examinations of the latest, cutting-edge developments in nucleic acid medicinal chemistry Perfect for medicinal and nucleic acid chemists, Nucleic Acids in Medicinal Chemistry and Chemical Biology will also earn a place in the libraries of biochemists, chemical biologists, and pharmaceutical researchers.

Nucleic Acids in Medicinal Chemistry and Chemical BiologyAn up-to-date and comprehensive exploration of nucleic acid medicinal chemistry and its applicationsIn Nucleic Acids in Medicinal Chemistry and Chemical Biology: Drug Development and Clinical Applications, a team of distinguished researchers delivers a comprehensive overview of the chemistry and biology of nucleic acids and their therapeutic applications. The book emphasizes the latest research in the field, including new technologies like CRISPR that create novel possibilities to edit mutated genes at the genomic DNA level and to treat inherited diseases and cancers.The authors explore the application of modified nucleosides and nucleotides in medicinal chemistry, a variety of current topics on nucleic acid chemistry and biology, nucleic acid drugs used to treat disease, and more. They also probe new domains of pharmaceutical research, offering the reader a wealth of new drug discovery opportunities emerging in this dynamic field.Readers will also find:* A thorough introduction to the basic terminology and knowledge of the field of nucleic acid medicinal chemistry* Comprehensive explorations of the methods used to determine the development of nucleic acid drugs* Practical discussions of new technologies, like CRISPR, nanotechnology-based delivery systems, synthetic biology, and DNA-encoded chemical libraries* In-depth examinations of the latest, cutting-edge developments in nucleic acid medicinal chemistryPerfect for medicinal and nucleic acid chemists, Nucleic Acids in Medicinal Chemistry and Chemical Biology will also earn a place in the libraries of biochemists, chemical biologists, and pharmaceutical researchers.

Chapter 1. Phosph(on)ate Prodrugs-prof.Junbiao Chang.docxchapter 2-Cyclic Dinucleotides A New Generation Drug for Immune Therapy-prof Xi.docxChapter 3-Enzymatic and Endogenous Synthesis of NAD(P)-derived Calcium-mobilizing Messengers-Prof Lee.docxChapter 4-Selenium Atom-modified Nucleic Acids for Structural, Functional and Diagnostic Studies-prof huang.docxchapter 5-Sequence-specific chromosomal DNA binders an unfulfilled promise-Prof Sugiyama.docxchapter 6- DNA synthesis and synthetic genome-prof Yuan.docxChapter 7-Methods for mapping of nucleic acids epigenetic modifications and its clinic applications-prof zhou.docxChapter 8-main text.docxChapter 9-nucleic acid-based nanocarriers as drug delivry system-Prof. Jongbum Lee-no figure.docxChapter 10.docxChapter 11-Oligonucleotide therapeutics-Prof. Yang.docxChapter 12-CRISPRCas9 a therapeutic solution by manipulating nucleic acids-prof.Deng.docxchapter 13-Aptamer properties, functions and applications-prof Tan.docxchapter 14-G-quadruplex as a platform for new perspectives in nucleic acid targeting for therapeutic applications-Prof.Sissi.doc