Robert K. Murray, MD, PhD Professor (Emeritus) of Biochemistry University of Toronto Toronto, Ontario

Preface SECTION I Structures & Functions of Proteins & Enzymes 1 Biochemistry & Medicine 2 Water & pH 3 Amino Acids & Peptides 4 Proteins: Determination of Primary Structure 5 Proteins: Higher Orders of Structure SECTION II Enzymes: Kinetics, Mechanism, Regulation, & Role of Transition Metals 6 Proteins: Myoglobin & Hemoglobin 7 Enzymes: Mechanism of Action 8 Enzymes: Kinetics 9 Enzymes: Regulation of Activities 10 The Biochemical Roles of Transition Metals SECTION III Bioenergetics 11 Bioenergetics: The Role of ATP 12 Biologic Oxidation 13 The Respiratory Chain & Oxidative Phosphorylation SECTION IV Metabolism of Carbohydrates 14 Overview of Metabolism & the Provision of Metabolic Fuels 15 Carbohydrates of Physiological Significance 16 The Citric Acid Cycle: The Central Pathway of Carbohydrate, Lipid, & Amino Acid Metabolism 17 Glycolysis & the Oxidation of Pyruvate 18 Metabolism of Glycogen 19 Gluconeogenesis & the Control of Blood Glucose 20 The Pentose Phosphate Pathway & Other Pathways of Hexose Metabolism SECTION V Metabolism of Lipids 21 Lipids of Physiologic Significance 22 Oxidation of Fatty Acids: Ketogenesis 23 Biosynthesis of Fatty Acids & Eicosanoids 24 Metabolism of Acylglycerols & Sphingolipids 25 Lipid Transport & Storage 26 Cholesterol Synthesis, Transport, & Excretion SECTION VI Metabolism of Proteins & Amino Acids 27 Biosynthesis of the Nutritionally Nonessential Amino Acids 28 Catabolism of Proteins & of Amino Acid Nitrogen 29 Catabolism of the Carbon Skeletons of Amino Acids 30 Conversion of Amino Acids to Specialized Products 31 Porphyrins & Bile Pigments SECTION VII Structure, Function, & Replication of Informational Macromolecules 32 Nucleotides 33 Metabolism of Purine & Pyrimidine Nucleotides 34 Nucleic Acid Structure & Function 35 DNA Organization, Replication, & Repair 36 RNA Synthesis, Processing, & Modification 37 Protein Synthesis & the Genetic Code 38 Regulation of Gene Expression 39 Molecular Genetics, Recombinant DNA, & Genomic Technology SECTION VIII Biochemistry of Extracellular & Intracellular Communication 40 Membranes: Structure & Function 41 The Diversity of the Endocrine System 42 Hormone Action & Signal Transduction SECTION IX Special Topics (A) 43 Nutrition, Digestion, & Absorption 44 Micronutrients: Vitamins & Minerals 45 Free Radicals & Antioxidant Nutrients 46 Glycoproteins 47 Metabolism of Xenobiotics 48 Clinical Biochemistry SECTION X Special Topics (B) 49 Intracellular Traffic & Sorting of Proteins 50 The Extracellular Matrix 51 Muscle & the Cytoskeleton 52 Plasma Proteins & Immunoglobulins 53 Red Blood Cells 54 White Blood Cells SECTION XI Special Topics (C) 55 Hemostasis & Thrombosis 56 Cancer: An Overview 57 The Biochemistry of Aging 58 Biochemical Case Histories The Answer Bank Index

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