Our knowledge and understanding of allergic diseases of the respiratory tract has improved to a point where new therapies are being developed for patient benefit. Inflammation and Allergy Drug Design explains the biologic science that underpins the pathophysiology of asthma and related disorders, as well as their mechanisms. This authoritative guide consists of 25 chapters, each detailing the cutting-edge developments in a particular field. It is divided into three parts, covering cytokines, chemokines, grow factors and mediators. This book allows immunologists, allergologists and researchers in the pharmaceutical industry to learn and appreciate the target biology in drug development. It also provides medical and pharmaceutical postgraduate students and clinicians with a basic understanding of allergic diseases in the respiratory tract.

Our knowledge and understanding of allergic diseases of therespiratory tract has improved to a point where new therapies arebeing developed for patient benefit.Inflammation and Allergy Drug Design explains thebiologic science that underpins the pathophysiology of asthma andrelated disorders, as well as their mechanisms. This authoritativeguide consists of 25 chapters, each detailing the cutting-edgedevelopments in a particular field. It is divided into three partscovering cytokines, chemokines, grow factors and mediators.This book allows immunologists, allergologists and researchersin the pharmaceutical industry to learn and appreciate the targetbiology in drug development. It also provides medical andpharmaceutical postgraduatestudents and clinicians with a basic understanding of allergicdiseases in the respiratory tract.

Contributors, viiPreface, xiiiPart I: Cells contributing to the pathogenesis of allergicdiseases in the respiratory tract1 Novel anti-infl ammatory drugs based on targeting lungdendritic cells and airway epithelial cells, 3Bart N. Lambrecht, Maud Plantinga, Monique Willart, and HamidaHammad2 Role of Th2 cells in the allergic diathesis, 15Marsha Wills-Karp3 Importance of Th17- and Th1-associated responses for thedevelopment of asthma, 27Tomohiro Yoshimoto, Hiroko Tsutsui, and Kenji Nakanishi4 Regulatory T cells, 39Chris Corrigan and Kimuli Ryanna5 A role for natural killer T-cell subsets in the pathogenesisof various allergic disorders, 59Hiroshi Watarai, Michishige Harada, Mayumi Tamari, and MasaruTaniguchi6 Regulatory roles of B cells in allergy and infl ammation67Kiyoshi Takatsu, Masashi Ikutani and Yoshinori Nagai7 Mast cells, 79Mindy Tsai and Stephen J. Galli8 Eosinophils, 107Nancy A. Lee, Mark V. Dahl, Elizabeth A. Jacobsen, and Sergei I.Ochkur9 Basophils in infl ammation and allergy drug design, 123Donald MacGlashan, Jr.10 Epithelial cells, 139Tillie-Louise Hackett, Stephanie Warner, Dorota Stefanowicz, andDarryl Knight11 Fibroblasts, 149Alastair G. Stewart, Lilian Soon, and Michael Schuliga12 Airway smooth muscle cells, 163Andrew J. Halayko and Pawan SharmaPart II: Cytokines contributing to the pathogenesis ofallergic diseases in the respiratory tract13 Interleukin 4, interleukin 13, and interleukin 9, 175Kenji Izuhara, Shoichiro Ohta, Hiroshi Shiraishi, and ShoichiSuzuki14 Interleukin 3, interleukin 5, andgranulocyte-macrophage colony-stimulating factor, 187Alba Llop-Guevara, Josip Marcinko, Ramzi Fattouh, and ManelJordana15 Interleukin 15, interleukin 17, and interleukin 25, 197Hiroshi Nakajima and Itsuo Iwamoto16 Thymic stromal lymphopoietin, 205Kazuhiko Arima and Yong-Jun Liu17 Interleukin 10, 215Whitney W. Stevens, Larry Borish, and John W. Steinke18 Tumor necrosis factor alpha, 225Christopher Brightling, Latifa Chachi, Dhan Desai, and YassineAmrani19 Profi brotic and angiogenic factors in asthma, 237Neville Berkman and Francesca Levi-Schaffer20 Chemokines, 253Luis M. Teran and Juan R. Velazquez21 Epithelial growth factors, 263Yasuhiro Gon and Shu HashimotoPart III: Other mediators contributing to the pathogenesis ofallergic diseases in the respiratory tract22 Prostanoids, 273Sarah A. Maher, Deborah L. Clarke, and Maria G. Belvisi23 Leukotrienes, 285Katsuhide Okunishi and Marc Peters-Golden24 Proteases in allergy, 297Keisuke Oboki and Hirohisa Saito25 Toll-like receptors, 307Jessica L. Allen, Aurelien Trompette, and Christopher L.KarpIndex, 317