The Metabolic Syndrome is a valuable reference text, covering all aspects of the metabolic syndrome and its constituent diseases including inflammation, oxidation and adipocytokines. This book explains the aetiology, pathogenesis and clinical treatment of all risk factors as well as the relationship with diabetes, non alcoholic fatty liver disease, polycystic ovary syndrome and coronary heart disease. The Metabolic Syndrome has been further improved from the 1st edition that was highly commended in 2006 Annual British Medical Association medical books competition. All chapters from the first edition are fully updated and this new edition contains an increase in international contributions and five new chapters on: Childhood obesity and metabolic syndrome Bariatric surgery for obesity Fitness Brain insulin resistance and appetite The nature of the insulin resistance seen in metabolic syndrome. This brand new edition of The Metabolic Syndrome will be an indispensable resource for all clinical researchers, physicians and scientists requiring detailed up-to-date information on the metabolic syndrome to further their own research or to treat and manage the syndrome and its complications. Specifically, the text will be of particular relevance to those involved and working in the fields of diabetes, endocrinology, obesity, cardiology, vascular disease and hepatology.

The Metabolic Syndrome is a valuable reference textcovering all aspects of the metabolic syndrome and its constituentdiseases including inflammation, oxidation and adipocytokines. Thisbook explains the aetiology, pathogenesis and clinical treatment ofall risk factors as well as the relationship with diabetes, nonalcoholic fatty liver disease, polycystic ovary syndrome andcoronary heart disease.The Metabolic Syndrome has been furtherimproved from the 1st edition that was highly commendedin 2006 Annual British Medical Association medical bookscompetition. All chapters from the first edition are fullyupdated and this new edition contains an increase in internationalcontributions and five new chapters on:* Childhood obesity and metabolic syndrome* Bariatric surgery for obesity* Fitness* Brain insulin resistance and appetite* The nature of the insulin resistance seen in metabolicsyndrome.This brand new edition of The Metabolic Syndromewill be an indispensable resource for all clinical researchersphysicians and scientists requiring detailed up-to-date informationon the metabolic syndrome to further their own research or to treatand manage the syndrome and its complications. Specifically, thetext will be of particular relevance to those involved and workingin the fields of diabetes, endocrinology, obesity, cardiologyvascular disease and hepatology.

List of Contributors viiForeword, Professor Sir George Alberti xiPreface xiii1 The Epidemiology of the Metabolic Syndrome and its Association with Diabetes, Cardiovascular Disease and Other Conditions 1Sarah H. Wild and Christopher D. Byrne2 Metabolic Syndrome and Ethnicity 19Therese Tillin and Nita G. Forouhi3 Developmental Origins of Endothelial Dysfunction: a Key Step in Cardiometabolic Disease 45Christopher Torrens, Geraldine F. Clough and Mark A. Hanson4 Developmental Origins of Insulin Resistance and Type 2 Diabetes 60Susan E. Ozanne and Kenneth Siddle5 The Metabolic Syndrome in Childhood 81Ram Weiss and Sonia Caprio6 Assessment of Insulin Sensitivity 88Julia Szendroedi, Esther Phielix and Michael Roden7 Recent Progress in Identifying Genes Contributing to Type 2 Diabetes and Metabolic Syndrome 106Weijia Xie, Timothy M. Frayling and Michael N. Weedon8 Endocrine Aspects of the Metabolic Syndrome 120Richard I.G. Holt and Peter H. Sönksen9 Brain Insulin Resistance 139Katharine F. Hunt, Yee Seun Cheah and Stephanie A. Amiel10 Cardiorespiratory Fitness and the Metabolic Syndrome 165Paul A. McAuley and Steven N. Blair11 Metabolic Syndrome and Mental Illness 177Richard I.G. Holt and Robert C. Peveler12 Atherothrombosis and the Metabolic Syndrome 194Kristina F. Standeven and Peter J. Grant13 Inflammation and Metabolic Syndrome 210Sridevi Devaraj, David Siegel and Ishwarlal Jialal14 Adipocytokine Dysregulation, Obesity and the Metabolic Syndrome 229Ulf Smith and Xiaolin Yang15 Non-Alcoholic Fatty Liver Disease 245Mohamed H. Ahmed and Christopher D. Byrne16 Polycystic Ovary Syndrome 278Naveed Sattar17 Nutrition: Its Relevance in Development and Treatment of the Metabolic Syndrome 297Lisa Te Morenga and Jim Mann18 Treatments for the Metabolic Syndrome 327Markolf Hanefeld, Ulrike Schatz and Frank Schaper19 Metabolic/Bariatric Surgery Therapy for the Metabolic Syndrome 347Henry BuchwaldIndex 357