Springer Book Archives

Introductory Paper.- Fungal Dimorphism: A Sideways Look.- Molecular Genetics of Morphogenetic Processes.- Molecular Controls of Conidiogenesis in Aspergillus nidulans.- Physical and Genetic Mapping of Candida albicans.- Genetic Basis for Dimorphism and Pathogenicity in Candida albicans.- The Multiple Chitin Synthase Genes of Candida albicans and Other Pathogenic Fungi-A Review.- Key Genes in the Regulation of Dimorphism of Candida albicans.- Switching and the Regulation of Gene Transcription in Candida albicans.- Characterization of Saccharomyces cerevisiae Pseudohyphal Growth.- Phase Transition in Wangiella dermatitidis: Identification of Cell-Division-Cycle Genes Involved in Yeast Bud Emergence.- Cell Biology and Biochemistry.- Morphological Aspects of Fungal Dimorphism.- Mathematical Analysis of the Cellular Basis of Fungal Dimorphism.- Quantification of Candida Morphology In Vitro and In Vivo.- Nature and Control of Cell Wall Biosynthesis.- Possible Roles of Mannoproteins in the Construction of Candida albicans Cell Wall.- Is There a Role for Sterols and Steroids in Fungal Growth and Transition from Yeast to Hyphal-Form and Vice-Versa? An Overview.- Factors Regulating Morphogenesis in Coccidioides immitis.- Dimorphism in Histoplasma capsulatum: Study of Cell Differentiation and Adaptation.- Biochemical and Physiological Aspects in the Dimorpism of Paracoccidioides brasiliensis.- Studies on Phase Transitions in Sporothrix schenkii: Possible Involvement of Protein Kinase C.- Clues about Chromoblastomycotic and Other Dematiaceous Fungal Pathogens based on Wangiella as a Model.- Dimorphism in Mucor Species.- Morphological Variation in Malassezia and Its Significance in Pityriasis Versicolor.- Dimorphism and Pathogenesis.- Complement Receptors in Candida albicans and Other Yeasts: Structure, Function and Role in Pathogenesis.- Immunogenic and Immunomodulatory Roles of Distinct Mannoprotein Constituents of Candida albicans.- Structural and Antigenic Correlates of Histoplasma capsulatum.- Pathogenicity of Wangiella dermatitidis.- Do Dimorphic Fungi more Easily Escape Host Defenses and Treatment?.- Diagnosis and Treatment of Mycoses.- Significance of Morphologic Form in Producing Immunodiagnostic Antigens for Dimorphic Fungal Pathogens.- Diagnosis of Histoplasmosis - Review of Current Methods.- Animal Models of Mycoses caused by Fungi that Produce Yeast- and Hyphal Forms.- Morphological Aspects of Antifungal Action.- Dimorphism and Candidosis: Clinical and Therapeutic Implications.- Treatment of Sporotrichosis, Blastomycosis and Histoplasmosis.- Azole Compounds in the Treatment of Paracoccidioidomycosis.- Current Therapy for Coccidioidomycosis.- Treatment of Phaeohyphomycosis and Pityriasis Versicolor.- Penicilium marneffei: Dimorphism and Treatment.

Fungal dimorphism is a topic that sounds inherently too rarified to attract more than a specialist audience. Yet some 230 individuals representing an eclectic mixture of interests, from basic science to medical practice, gathered in Churchill College, Cambridge in Semptember 1992 for a meeting devoted only to this subject. The symposium was the fourth in a series "Topics in Mycology" to be jointly organized by the Janssen Research Foundation and the International Society for Human and Animal Mycology. The participants enjoyed a rich and varied diet of oral presentations and poster displays in the field of fungal morphogenesis. This book sets down in print the material presented at the dimorphism symposium. We think that the high quality of these papers conveys very well the flavor of what was an excellent meeting. The selection of contributions in this volume covers very wide ground indeed. Chapters devoted to some non-pathogenic fungi are included, because the scientific basis of morphological development belongs to the fields of cellular and molecular biology: it does not recognize the boundary imposed by considerations of virulence of a fungus for a human host. Yet morphogenetic change in those fungi that do cause human disease frequently appears to be a component of the pathological process: many important pathogens change from a hyphal form in the external environment to a round form in infected tissues. This relationship between dimorphism and pathogenicity is the point of contact between pure biology and medicine.