Advances in Bone Marrow Transplant: Stem Cells and Tcell Depletion: Tcells, Graft versus Host Disease and Graft versus Leukemia: Innovative Approaches for Blood and Marrow Transplantation (R. Champlin et al.). Clinical Update on Malignant Lymphoma and Myeloma: Mechanism/Therapy: Mechanisms of Chromosomal Translocations in Malignant Lymphomas (M.J. Uppenkamp et al.). Update on Advancement in Leukemia: Characterization of Nras Promoter Mutations in Leukemia (H. Iland et al.). Update on Role of HIV and Viruses in Hematopoiesis: AIDSrelated NonHodgkin Lymphomas: Molecular Genetics, Viral Infection, and Cytokine Deregulation (G. Gaidano et al.). Molecular Regulation of Hematopoietic Genes and Gene Transfer: Targeted Gene Transfer into CD4 Positive Cells by HIVbased Retroviral Vectors (T. Shimada, K. Miyake). Cytokine Action and Signal Transduction: Expression and Signal Transduction of the FLT3 Tyrosine Kinase Receptor (O. Rosnet et al.). Thrombopoiesis and Erythropoiesis: An Update: Biological Effects of Thrombopoietin (TPO) (A. Grossman et al.). Cytokines and Myeloproliferative Disorders: The Role of GMCSF in Chronic Infections (C. Nath et al.). New Directions in Iron Chelating Therapy: Molecular Pathogenesis of Hemochromatosis (C. Camaschella et al.). 84 additional articles. Index.

This volume of Molecular Biology of Hematopoiesis is dedicated to John W. Adam son, M. D. , Tadamitsu Kishimoto, M. D. , Robert C. Gallo, M. D. , Arthur W. Nienhuis, M. D. , and Franco Mandelli, M. D. , for their contributions in developing an overall view of the state-of-the-art knowledge in the field of hematopoiesis. Richard Champlin, among other renowned clinicians, presented updated information on stem cells and T-cell depletion for bone marrow transplant. A clinical update on thrombopoietin was presented by Pamela Hunt of Amgen and by Kenneth Kaushansky. Arthur Nienhuis' and Katherine Turner's contribu tions to our current knowledge and advances in the fields of growth factors and gene transfer were also recognized during the 9th Symposium on Molecular Biology of Hematopoiesis in Genoa. The chapters cover such diverse areas as preclinical and clinical updates on growth factors and positive and negative regulatory molecules. "Advances in Leukemia: Mechanism and Treatment by Interferon" was presented by Professor Sante Tura. Readers will find presentation of exciting advances that have occurred in the area of hematopoiesis. The elucidation of gene structures of key growth factor proteins such as IL-12 and IL-II will lead to new insights and new approaches in understanding the regulation of hematopoiesis, as well as application of new growth factors.