Synthesizing our expanding knowledge of the positive and negative consequences of cardiac adaptation, this analysis of developmental mechanisms, hypertrophy, and the role of the sympathetic nervous system will boost research into a range of cardiac conditions.

Comparative Aspects of Cardiac Adaptation.- Molecular Mechanisms in Cardiac Development.- Prenatal Adaptation to Overload.- Hypoxia and Mechanical Factors Drive Coronary Vascular Development.- Cardiac Metabolic Adaptation During Postnatal Development.- Ontogenetic Adaptation to Chronic Hypoxia.- Heart and Arterial Aging.- Differences in Concentric Cardiac Hypertrophy and Eccentric Hypertrophy.- Cardiac Adaptation to Volume Overload.- Functional Adaptation during the Development of Cardiac Hypertrophy and Heart Failure in Females.- Impact of Gender and Exercise on Cardiac Adaptation to Pathological Situations.- Cardiopulmonary Adaptation to High Altitude.- Cardiac Hypertrophy in Hypertension.- Exercise Training and Adverse Cardiac Remodeling and Dysfunction in Mice.- The Athlete’s Heart.- Role of β - Adrenoceptor/Adenylyl Cyclase System in Cardiac Hypertrophy.- Role of Phospholipase C in the α1 - Adrenoceptor Mediated Cardiac Hypertrophy.- Maladaptive Cardiac Remodeling: Signal-dependent Regulation of the Fibrotic Gene Program by CLP-1 in the Hypertrophic Heart.- Role of Sirtuins in Regulation of Cardiac Adaptation Associated with Hypertrophy.- Adaptation of Cardiac and Skeletal Muscle Mitochondria to Endurance Training: Implications for Cardiac Protection.- Adenosine as an Endogenous Adaptive Cardiac Antihypertrophic and Antiremodelling Factor.- Myocardial Adaptation and Autophagy.- Modulatory Role of VEGF in Angiogenesis for Cell Survival.- The Role of CaM Kinase II in Cardiac Function in Health and Disease.