This volume provides a comprehensive summary of the field, with expert recommendations on prediction and management. It details the recent consensus guidelines (2012) updating the definition of pancreatitis and its complications. The text thoughtfully summarizes the current prediction models for severe acute pancreatitis, including laboratory, clinical and imaging parameters. It also highlights the relative advantages and disadvantages of several of these models. Evidenced-based guidelines into medical and surgical management of both the hospitalized and discharged patient are described, with recommendations from expert authors pertaining to various clinical situations. Finally, complications of acute pancreatitis and their management, including the use of cutting-edge minimally-invasive therapies, is discussed.

Prediction and Management of Severe Acute Pancreatitis will serve as the fundamental source for those interested in and treating this disease, including practicing gastroenterologists, surgeons, radiologists, intensivists, hospitalists and pathologists.

Part I.  Definitions of Severe and Necrotizing Pancreatitis

Chapter 1. Revised Atlanta Classification of Acute Pancreatitis

Rupjyoti Talukdar and Santhi Swaroop Vege

Chapter 2. Organ Failure and Acute Pancreatitis

Colin D. Johnson

Chapter 3. Sterile and Infected Pancreatic Necrosis

Elham Afghani and Vikesh K. Singh

Chapter 4. Evolving Definitions of Severe Acute Pancreatitis

John A. Windsor and Maxim S. Petrov

Part II. Predictors and Characteristics of Severe Acute and Necrotizing Pancreatitis

Chapter 5. Clinical Predictors

Rawad Mounzer and Georgios I. Papachristou

Chapter 6. Imaging Predictors

Thomas L. Bollen

Chapter 7. Predictive Scoring Systems in Acute Pancreatitis

Kavya M. Reddy and Bechien U. Wu

Part III. Medical Management of Severe and Necrotizing Acute Pancreatitis

Chapter 8. Fluid Resuscitation in Acute Pancreatitis

Kartik Sampath and Timothy B. Gardner

Chapter 9. Antibiotic Therapy 

Wesley Leung and Andres Gelrud

Chapter 10. Nutrition in Severe Acute Pancreatitis

Kishore Vipperla and Stephen J. O’Keefe

Chapter 11. Pharmacologic Therapy

Walter G. Park

Part IV.  Interventional Management of Severe and Necrotizing Acute Pancreatitis

Chapter 12. Management of Ductal Leaks

Michael C. Larsen and Richard Kozarek

Chapter 13. Endoscopic Management of Severe Gallstone Pancreatitis

Takao Itoi and Peter V. Draganov

Chapter 14. Direct Endoscopic Necrosectomy

Todd H. Baron

Chapter 15. Retroperitoneoscopic Approaches for Infected Necrotizing Pancreatitis

Janneke van Grinsven, Marc G. Besselink, Olaf .J. Bakker, Sandra van Brunschot, Marja A. Boermeester, and Hjalmar C. van Santvoort

Chapter 16. Surgical Approaches

Roshni Venugopal, Kristin Pokorney-Colling, and Greg J. Beilman

Chapter 17. Interventions for Necrotizing Pancreatitis: A Multidisciplinary Approach

Martin L Freeman, Guru Trikudanathan, Mustafa Arain, Greg J. Beilman, Shawn

Mallery, and Rajeev Attam