Tissue engineering and regenerative medicine will ultimately have a more profound impact than most of us can fully appreciate. The combination of the principles of engineering with advances in the material sciences, and an increased understanding of developmental biology has the potential to influence developments in medicine and biotechnology more than any single advance in these fields during the last several decades. I would first like to applaud the volume editor, Dr. Pietrzak, and the authors for their efforts in bringing together a group of interrelated topics to create a textbook emphasizing the Tissue Engineered generation of musculoskeletal tissue. The authors of this book are all established experts in their respective fields. The publication of a separate volume dedicated to musculoskeletal tissue regeneration as part of a series focusing on orthopedic biology and medicine is a reflection of the tremendous growth of knowledge and ongoing developments that have occurred in this field over the last decade. Musculoskeletal Tissue Regeneration: Biological Materials and Methods is intended to cover the basic fundamentals and early treatment of musculoskeletal disease, tissue loss and wound healing, as well as provide a comprehensive summary of recent advances in regenerative medicine and tissue engineering as they relate to the musculoskeletal system, and should serve as a reference for researchers and graduate students in this discipline.

Chapter 1 Musculoskeletal and Wound Treatment Through the Ages: A Brief Historical Tour William S. Pietrzak, Ph.D. Chapter 2 Musculoskeletal Fundamentals: Form, Function, and a Survey of Healing Strategies Wei Shen, M.D., Ph.D., Mario Ferretti, M.D., Mollie Manley, B.S., Freddie Fu, M.D. Chapter 3 Overview of Fracture Repair Bruce Doll, D.D.S, Ph.D., Matthew Aleef, M.D., Jeffrey O. Hollinger, D.D.S., Ph.D. Section II. Hard Tissue Technologies Chapter 4 Autograft Bone Takaaki Fujishiro, M.D., Ph.D., Hideo Kobayashi, M.D., Ph.D., Thomas W. Bauer, M.D., Ph.D. Chapter 5. Biology of Bone Allograft and Clinical Application Victor M. Goldberg, M.D. Chapter 6 Demineralized Bone Matrix: Maximizing New Bone Formation for Successful Bone Implantation Lloyd Wolfinbarger Jr., Ph.D., Liisa M. Eisenlohr, Ph.D., M.B.A., Katrina Ruth, B.S. Chapter 7 Deproteinized Bovine Bone Xenograft Andreas Stavropoulos, D.D.S., Ph.D. Chapter 8 Bioactive Bioceramics Racquel Zapanta LeGeros, Ph.D., Guy Daculsi, John P. LeGeros Chapter 9 Distraction Osteogenesis of the Orthopedic Skeleton: Basic Principles and Clinical Applications Mikhail L. Samchukov, M.D., Marina R. Makarov, M.D., Alexander M. Cherkashin, M.D., John G. Birch, M.D. Chapter 10 Distraction Osteogenesis of the Facial Skeleton Robert J. Havlik, M.D. Chapter 11 Bone Morphogenetic Proteins and Other Bone Growth Factors Barbara D. Boyan, Ph.D., Ramsey C. Kinney, Kimberly Singh, Joseph K. Williams, Yolanda Cillo, Zvi Schwartz Chapter 12 Biological Approaches to Spinal Fusion Andrew K. Simpson, B.S., Peter G. Whang, M.D., Jonathan Grauer, M.D. Chapter 13 Electrical Bone Stimulation Josh Simon, Ph.D., Bruce Simon, Ph.D. Section III Soft Tissue Technologies Chapter 14 Mensical Repair Techniques F. Alan Barber, M.D., F.A.C.S. Chapter 15 Lessons Learned From Our First 100 Meniscus Allograft Transplants in Arthritic Knees Kevin R. Stone, M.D., Ann W. Walgenbach, RN,NP, Abhi Freyer, B.A.S. Chapter 16 Tissue Engineering of the Mensicus Pieter Buma, Ph.D., Marloes van Meel, Tony van Tienen, M.D., Ph.D., Rene Veth, M.D., Ph.D. Chapter 17 Osteochondral Grafts Simon Görtz, M.D., Michael B. Boyd, D.O., William D. Bugbee, M.D. Chapter 18 Autologous Chondrocyte Cartilage Repair Stefan Marlovits, M.D., M.B.A. Chapter 19 Autograft and Allograft ACL Reconstruction: Construct Rationale Keith W. Lawhorn, M.D., Stephen M. Howell, M.D. Chapter 20 Tissue Engineered Anterior Cruciate Ligament Graft Timothy M. Simon, Ph.D., Douglas W. Jackson, M.D. Chapter 21 Biologic Scaffold Materials for Orthopaedic Soft Tissue Reconstruction Stephen F. Badylak, D.V.M., Ph.D., M.D. Chapter 22 Muscle Repair After Injury and Disease Fabrisia Ambrosio, PhD, MPT, Yong Li, MD, PhD, Arvydas Usas, MD, Michael L. Boninger, MD, Johnny Huard, PhD Section 4 Generalized Approaches Chapter 23 Principles of Musculoskeletal Tissue Banking Theodore I. Malinin, M.S., M.D. Chapter 24 Bioabsorbable Polymer Applications in Musculoskeletal Fixation and Healing William S. Pietrzak, Ph.D. Chapter 25 Tissue Adhesives: Science,

Tissue engineering and regenerative medicine will ultimately have a more profound impact than most of us can fully appreciate. The combination of the principles of engineering with advances in the material sciences, and an increased understanding of developmental biology has the potential to influence developments in medicine and biotechnology more than any single advance in these fields during the last several decades. I would first like to applaud the volume editor, Dr. Pietrzak, and the authors for their efforts in bringing together a group of interrelated topics to create a textbook emphasizing the Tissue Engineered generation of musculoskeletal tissue. The authors of this book are all established experts in their respective fields. The publication of a separate volume dedicated to musculoskeletal tissue regeneration as part of a series focusing on orthopedic biology and medicine is a reflection of the tremendous growth of knowledge and ongoing developments that have occurred in this field over the last decade. Musculoskeletal Tissue Regeneration: Biological Materials and Methods is intended to cover the basic fundamentals and early treatment of musculoskeletal disease, tissue loss and wound healing, as well as provide a comprehensive summary of recent advances in regenerative medicine and tissue engineering as they relate to the musculoskeletal system, and should serve as a reference for researchers and graduate students in this discipline.