In this newly updated, second edition, leading medical specialists critically review for the general practitioner the latest techniques for the clinical management of diabetic neuropathy. These authoritative contributors focus on the practical aspects of diabetic neuropathy and describe in detail the treatments that are currently available or expected to become available in the near future. They also include concise discussions of the pathogenesis of diabetic neuropathy and highlight the relatively unknown features of neuropathy that can significantly impact a patient's life. Comprehensive, up-to-date bibliographies at the end of each chapter provide an opportunity for the interested physician to gain a more detailed picture of a particular topic.

In this newly updated, second edition, leading medical specialists critically review for the general practitioner the latest techniques for the clinical management of diabetic neuropathy. These authoritative contributors focus on the practical aspects of diabetic neuropathy and describe in detail the treatments that are currently available or expected to become available in the near future. They also include concise discussions of the pathogenesis of diabetic neuropathy and highlight the relatively unknown features of neuropathy that can significantly impact a patient's life. Comprehensive, up-to-date bibliographies at the end of each chapter provide an opportunity for the interested physician to gain a more detailed picture of a particular topic.

Historical Aspects of Diabetic Neuropathies.- The Epidemiology of Diabetic Neuropathy.- Genomics of Diabetic Neuropathy.- Transgenic and Gene Knockout Analysis of Diabetic Neuropathy.- Hyperglycemia-Initiated Mechanisms in Diabetic Neuropathy.- Effectors—Sonic Hedgehog and p38 Mitogen-Activated Protein Kinase.- Neuronal and Schwann Cell Death in Diabetic Neuropathy.- Metabolic-Functional-Structural Correlations in Somatic Neuropathies in the Spontaneously Type 1 and Type 2 Diabetic BB-Rats.- Experimental Diabetic Autonomic Neuropathy.- Spinal Cord.- Diabetic Encephalopathy.- Microangiopathy, Diabetes, and the Peripheral Nervous System.- Pathogenesis of Human Diabetic Neuropathy.- Clinical Features of Diabetic Polyneuropathy.- Micro- and Macrovascular Disease in Diabetic Neuropathy.- Clinical Diagnosis of Diabetic Neuropathy.- Punch Skin Biopsy in Diabetic Neuropathy.- Aldose Reductase Inhibitors for the Treatment of Diabetic Neuropathy.- Other Therapeutic Agents for the Treatment of Diabetic Neuropathy.- Pathophysiology of Neuropathic Pain.- Treatment of Painful Diabetic Neuropathy.- Focal and Multifocal Diabetic Neuropathy.- Hypoglycemia and the Autonomic Nervous System.- Cardiovascular Autonomic Neuropathy.- Postural Hypotension and Anhidrosis.- Gastrointestinal Syndromes Due to Diabetes Mellitus.- Genitourinary Complications.- Management of Diabetic Foot Complications.