It is a pleasure to introduce this new book, Clinical and Pathological Aspects of Skin Diseases in Endocrine, Metabolic, Nutritional, and Deposition Disease, edited by two of my friends and respected colleagues, Franco Rongioletti and Bruce R. Smoller. In fact, I was very ent- siastic when I learned that they were preparing this work. Although endocrine, metabolic, w, and deposition diseases are regularly included in general textbooks of dermatology and d- matopathology, one gains the general impression that these topics receive little emphasis and are mainly included for completeness. The prospect of having all of this information in one volume, lovingly described and detailed by experts in the feld, should be of great interest not only to dermatologists, pathologists, and dermatopathologists but also to internists and en- crinologists, who may well gain a different perspective on these disorders. As a derma- pathologist, I am also pleased that this project has been organized and undertaken by two distinguished authorities in cutaneous pathology. This assures a close integration of histo- thology and other laboratory techniques with the clinical aspects of these disorders, which will make it possible – perhaps for the frst time – to view these conditions in a truly comprehensive way. So I invite you, the reader, to open this volume and dig in; be prepared for an eye-catching, intellectually stimulating, and ultimately rewarding experience! Charlottesville, VA James W. Patterson v w Foreword II Dermatopathology is a bridge between Dermatology and Pathology.

Part I. CUTANEOUS ENDOCRINE DISEASE 1. ADRENAL DISEASE Kennet Calder/Bruce Smoller 1.1.Cushing's syndrome 1.2.Addison's disease 1.3.Pheocromocytoma 2. PANCREAS DISEASE AND DIABETES MELLITUS Franco Rongioletti 2.1. Non infectious skin manifestations 2.1.1 Necrobiosis lipoidica 2.1.2 Diabetic dermopathy 2.1.3 Granuloma annulare 2.1.4 Diabetic thick skin 2.1.5 Bullosis diabeticorum 2.1.6 Eruptive xanthomas 2.1.7 Acquired perforating dermatosis 2.1.8 Acanthosis nigricans 2.1.9 Miscellanea 2.2 Cutaneous infections 2.2.1 Bacterial Infections 2.2.2 Candida Infections 2.2.3 Dermatophyte Infections 2.2.4 Rare infections 2.3 Complications due to diabetic neuropathy and vasculopathy 2.4 Complications due to diabetes treatment 3. THYROID DISEASE Alfredo Rebora/Franco Rongioletti 3.1.Hyperthyroidism 3.2.Hypothyroidism 4. PITUITARY GLAND DISEASE Martina Montinari/Franco Rongioletti 4.1. Acromegaly 4.2. Hyperprolactinemia 4.3 Cushing’s disease 4.4 Panhypopituitarism 5. PARATHYROID DISEASE Yann Charli-Joseph/Marcela Saeb-Lima 5.1.Hyperparathyroidism 5.1.1 Familial (hereditary) forms of primary hyperparathyroidism 5.1.2 Hyperparathyroidism related to renal failure 5.1.3 Other cutaneous manifestations 5.2. Hypoparathyroidism Part II.CUTANEOUS METABOLIC DISEASE 6. DYSLIPIDEMIA (HYPERLIPIDEMIA) Terry Katona/Bruce Smoller 6.1 Specific xanthomas 6.1.1 Planar xanthomas 6.1.2 Eruptive xanthomas 6.1.3 Tuberous xanthomas 6.1.4 Tendinous xanthomas 6.1.5 Cholesterotic fibrous histiocytoma 7. GOUT Uma Sundram 8.LIPOMATOSIS Uma Sundram 8.1 Diffuse lipomatosis 8.2 Familial multiple lipomatosis 8.3 Multiple symmetric lipomatosis 8.4 Adiposis dolorosa (Dercum’s disease) 8.5 Syndromes that can demonstrate multiple lipomas 8.5.1 Proteus syndrome 8.5.2 Bannayan-Zonana syndrome 9.OBESITY Jessica Linder/Amena Usmani/Maria Miteva/Camillo Ricordi/Paolo Romanelli 9.1 Achrocordons 9.2 Adiposis dolorosa 9.3 Hidradenitis suppurativa 9.4 Lymphedema 9.5Acanthosis nigricans 9.6 Strie distensae 9.7 Hyperandrogenism 9.8 Plantar hyperkeratosis 9.9 Other skin manifestations 10.PORPHYRIAS Jaqueline Junkins-Hopkins 10.1 Congenital erythropoietic porphyria (CEP) 10.2 Porphyria cutanea tarda 10.3 Erythropoietic protoporphyria 10.4 Hepatoerythropoietic porphyria 10.5 Pseudoporphyria 11.HEMOCHROMATOSIS Aurora Parodi/Franco Rongioletti 12.THE METABOLIC SYNDROME IN PSORIASIS Paolo Gisondi/GiampieroGirolomoni III. CUTANEOUS NUTRITIONAL DISEASE 13.ACQUIRED NUTRITIONAL DEFICIENCIES Martina Montinari/Aurora Parodi/Franco Rongioletti 13.1 Scurvy 13.2 Acquired acrodermatitis enteropatica (dermatitis associated with zinc deficiency) 13.3 Pellagra 13.4 Iron deficiency 13.5 Other nutritional deficiencies 14.ANOREXIA NERVOSA Jameel Ahmad Brown 14.1 Xerosis 14.2 Lanugo-like body hairs 14.3 Alopecia 14.4 Hypercarotenemia/Carotenoderma 14.5 Acne 14.6 Acrocyanosis 14.7 Pruritus 14.8 Purpura 14.9 Nail Changes 14.10 Angular Cheilitis 14.11 Russell’s Sign 14.12 Finger Clubbing, fixed drug eruption, and photosensitivity dermatitis 14.13 Miscellanea 15.ALCOHOL ABUSE Torello Lotti/ Angelo Massimiliano D’Erme 15.1 Skin diseases significantly associated with alcoholism 15.2 Nutritional and metabolic diseases with skin symptoms induced by alcoholism 15.3 Skin diseases exacerbated by alcohol 16.GLUCAGONOMA SYNDROME AND NECROLYTIC MIGRATORY ERYTHEMA Franco Rongioletti IV. CUTANEOUS DEPOSITION DISEASE 17. AMYLOIDOSES Franco Rongioletti 17.1 Acquired systemic amylodoses with cutaneous involvement 17.1.1 Primary and myeloma-associated amyloidosis (AL amyloidosis) 17.1.2 Secondary systemic AA amyloidosis 17.1.3 ? 2-Microglobulin hemodialysis-associated amyloidosis 17.2. Hereditary/familial systemic amyloidoses with cutaneous involvement 17.3. Localized cutaneous amyloidoses 17.3.1 Primary localized cutaneous amyloidoses 17.3.2. Secondary localized cutaneous amyloidosis 18.MUCINOSES Franco Rongioletti 18.1

It is a pleasure to introduce this new book, Clinical and Pathological Aspects of Skin Diseases in Endocrine, Metabolic, Nutritional, and Deposition Disease, edited by two of my friends and respected colleagues, Franco Rongioletti and Bruce R. Smoller. In fact, I was very ent- siastic when I learned that they were preparing this work. Although endocrine, metabolic, w, and deposition diseases are regularly included in general textbooks of dermatology and d- matopathology, one gains the general impression that these topics receive little emphasis and are mainly included for completeness. The prospect of having all of this information in one volume, lovingly described and detailed by experts in the feld, should be of great interest not only to dermatologists, pathologists, and dermatopathologists but also to internists and en- crinologists, who may well gain a different perspective on these disorders. As a derma- pathologist, I am also pleased that this project has been organized and undertaken by two distinguished authorities in cutaneous pathology. This assures a close integration of histo- thology and other laboratory techniques with the clinical aspects of these disorders, which will make it possible – perhaps for the frst time – to view these conditions in a truly comprehensive way. So I invite you, the reader, to open this volume and dig in; be prepared for an eye-catching, intellectually stimulating, and ultimately rewarding experience! Charlottesville, VA James W. Patterson v w Foreword II Dermatopathology is a bridge between Dermatology and Pathology.