This book represents my experience teaching graduate students in Biomedical Science at Hood College. Being science majors, the students have a limited background in philosophy and ethics. Most of the graduate students are employed at area research laboratories while also pursuing a Master of Science degree. Their practical day-to-day experience in scientific research is helpful in discussions of responsible conduct of research cases. Being aware of increased cases of misconduct the United States established the Office of Research Integrity (ORI). Their publication, Introduction to the Responsible Conduct of Research, defines misconduct as fabrication, falsification, and plagiarism. Concern for the breach of public trust with repercussions in scientific funding has led to mandates for courses in ethics for students pursuing a scientific career. In addition, the Human Genome Project megaproject funded Ethical, Legal, and Social Implications Research (genome.gov/ELSI/) recognizing that the genetic information produced by the project would come with applied ethical dilemmas. Teaching can be understood as conveying knowledge from generation to generation. Likewise systems of morality are collective acquisitions built up over millennia with social norms and values that aim to maintain social order. Research does not support the premise that knowing the rules of conduct will prevent misconduct. Indeed, compliance with rules can give a false sense of security, especially if the ethical reasoning grounding the rules is not understood. Therefore, I try to sketch a path through the potential phases and avenues of a scientific career, imagining that a person may do basic research, serve on ethics committees, and engage the public in ethical use of new advances in genetics. As a result the content of this text is divided into three parts. The first part deals with foundational material on science and ethics and cases that highlight proper scientific professional conduct. The second part deals with clinical research through which a research discovery is moved to the bedside of patients and the ethical parameters of the transition. The third part sketches the ethical dilemmas evolving from progress in genetic information to clinical applications. Helping students find a moral compass, a grounding of why one ought to behave in ethical ways in their profession and more generally in life is challenging. Doing so increases their awareness and mine of potential dilemmas and how to deal with them ethically.

This book represents my experience teaching graduate students in Biomedical Science at Hood College. Being science majors, the students have a limited background in philosophy and ethics. Most of the graduate students are employed at area research laboratories while also pursuing a Master of Science degree. Their practical day-to-day experience in scientific research is helpful in discussions of responsible conduct of research cases. Being aware of increased cases of misconduct the United States established the Office of Research Integrity (ORI). Their publication, Introduction to the Responsible Conduct of Research, defines misconduct as fabrication, falsification, and plagiarism. Concern for the breach of public trust with repercussions in scientific funding has led to mandates for courses in ethics for students pursuing a scientific career. In addition, the Human Genome Project megaproject funded Ethical, Legal, and Social Implications Research (genome.gov/ELSI/) recognizing that the genetic information produced by the project would come with applied ethical dilemmas. Teaching can be understood as conveying knowledge from generation to generation. Likewise systems of morality are collective acquisitions built up over millennia with social norms and values that aim to maintain social order. Research does not support the premise that knowing the rules of conduct will prevent misconduct. Indeed, compliance with rules can give a false sense of security, especially if the ethical reasoning grounding the rules is not understood. Therefore, I try to sketch a path through the potential phases and avenues of a scientific career, imagining that a person may do basic research, serve on ethics committees, and engage the public in ethical use of new advances in genetics. As a result the content of this text is divided into three parts. The first part deals with foundational material on science and ethics and cases that highlight proper scientific professional conduct. The second part deals with clinical research through which a research discovery is moved to the bedside of patients and the ethical parameters of the transition. The third part sketches the ethical dilemmas evolving from progress in genetic information to clinical applications. Helping students find a moral compass, a grounding of why one ought to behave in ethical ways in their profession and more generally in life is challenging. Doing so increases their awareness and mine of potential dilemmas and how to deal with them ethically.

Table of Contents: Acknowledgments / Introduction / Part I: Responsible Conduct in Research / Professional Scientific Conduct / Ethics / Preventing Misconduct / Part II: Research with Human Subjects: Clinical Research Ethics / Evolution of Regulations / Belmont Principles / Balancing Principles / Misconduct in Clinical Trials / Recognizing Patient Autonomy / Part III: Genetic Medicine / New Paradigms / Model Animals Lead to Human Discoveries / Genetic Testing vs. Screening / Ethical Issues in Genetic Medicine / Is the Prospect of Eugenics a Threat to Genetic Medicine? / Where Do We Go from Here / Bibliography / Author Biography