Beschreibung:
In this book, the authors discuss the genetics, geographic variation and disorders associated with skin pigmentation. Topics include the melanocortin-1 receptor as a key melanoma risk determinant and a critical regulator of the UV DNA damage repair response; three major signaling pathways involved in the establishment of mammalian skin and hair coloration via the regulation of tyrosinase activity; multiple genes and diverse hierarchical pathways that affect human pigmentation; acquired skin pigmenation; the pro-opiomelanocortin (POMC) and melanocortin systems in the regulation of human skin pigmentation; and an overview on the melanocyte precursor migration from neural cres.
In this book, the authors discuss the genetics, geographic variation and disorders associated with skin pigmentation. Topics include the melanocortin-1 receptor as a key melanoma risk determinant and a critical regulator of the UV DNA damage repair response; three major signaling pathways involved in the establishment of mammalian skin and hair coloration via the regulation of tyrosinase activity; multiple genes and diverse hierarchical pathways that affect human pigmentation; acquired skin pigmenation; the pro-opiomelanocortin (POMC) and melanocortin systems in the regulation of human skin pigmentation; and an overview on the melanocyte precursor migration from neural cres.