Jane Flint is Professor Emerita of Molecular Biology at Princeton University. Dr. Flint's research focused on investigation of the mechanisms by which viral gene products modulate host pathways and antiviral defenses to allow efficient reproduction in normal human cells of adenoviruses, viruses that are used in such therapeutic applications as gene transfer and cancer treatment.
 
Vincent R. Racaniello is Higgins Professor of Microbiology & Immunology at Columbia University Vagelos College of Physicians & Surgeons. Dr. Racaniello has been studying viruses for over 40 years, including polio- virus, rhinovirus, enteroviruses, hepatitis C virus, and Zika virus. He blogs about virus-es at virology.ws and is host of This Week in Virology.
 
Glenn F. Rall is a Professor and the Chief Academic Officer at the Fox Chase Cancer Center, and is an Adjunct Professor in the Microbiology and Immunology departments at the University of Pennsylvania, as well as Thomas Jefferson, Drexel, and Temple Universities. Dr. Rall studies viral infections of the brain and the immune responses to those infections, with the goal of defining how viruses contribute to disease.
 
Theodora Hatziioannou is a Research Associate Professor at Rockefeller University and is actively involved in teaching programs at Albert Einstein College of Medicine. Dr. Hatziioannou has worked on multiple viruses with a focus on retroviruses and the molecular mechanisms that govern virus tropism and on the improvement of animal models for human disease.
 
Anna Marie Skalka is a Professor Emerita and former Senior Vice President for Basic Research at the Fox Chase Cancer Center. Dr. Skalka is internationally recognized for her contributions to the understanding of the biochemical mechanisms by which retroviruses replicate and insert their genetic material into the host genome, as well as her research into other molecular aspects of retrovirus biology.

Volume 1
 
Preface
 
Acknowledgments
 
About the Authors
 
PART I: The Science of Virology
 
1 Foundations
 
Luria's Credo
 
Viruses Defined
 
Why We Study Viruses
 
Viruses Are Everywhere
 
Viruses Infect All Living Things
 
Viruses Can Cause Human Disease
 
Viruses Can Be Beneficial
 
Viruses "R" Us
 
Viruses Can Cross Species Boundaries
 
Viruses Are Unique Tools To Study Biology
 
Virus Prehistory
 
Viral Infections in Antiquity
 
The First Vaccines Microorganisms as Pathogenic Agents
 
Discovery of Viruses
 
The Defining Properties of Viruses
 
The Structural Simplicity of Virus Particles
 
The Intracellular Parasitism of Viruses
 
Cataloging Animal Viruses
 
The Classical System
 
Classification by Genome Type: the Baltimore System
 
A Common Strategy for Viral Propagation
 
Perspectives
 
References
 
Study Questions
 
2 The Infectious Cycle
 
Introduction
 
The Infectious Cycle
 
The Cell
 
Entering Cells
 
Viral RNA Synthesis
 
Viral Protein Synthesis
 
Viral Genome Replication
 
Assembly of Progeny Virus Particles
 
Viral Pathogenesis
 
Overcoming Host Defenses
 
Cultivation of Viruses
 
Cell Culture
 
Embryonated Eggs
 
Laboratory Animals
 
Assay of Viruses
 
Measurement of Infectious Units
 
Efficiency of Plating
 
Measurement of Virus Particles
 
Viral Reproduction: the Burst Concept
 
The One-Step Growth Cycle
 
One-Step Growth Analysis: a Valuable Tool for Studying Animal Viruses
 
Global Analysis
 
DNA Microarrays
 
Mass Spectrometry
 
Protein-Protein Interactions
 
Single-Cell Virology
 
Perspectives
 
References
 
Study Questions
 
PART II: Molecular Biology
 
3 Genomes and Genetics
 
Introduction
 
Genome Principles and the Baltimore System
 
Structure and Complexity of Viral Genomes
 
DNA Genomes
 
RNA Genomes
 
What Do Viral Genomes Look Like?
 
Coding Strategies
 
What Can Viral Sequences Tell Us?
 
The "Big and Small" of Viral Genomes: Does Size Matter?
 
The Origin of Viral Genomes
 
Genetic Analysis of Viruses
 
Classical Genetic Methods
 
Engineering Mutations into Viral Genomes
 
Engineering Viral Genomes: Viral Vectors
 
Perspectives
 
References
 
Study Questions
 
4 Structure
 
Introduction
 
Functions of the Virion
 
Nomenclature
 
Methods for Studying Virus Structure
 
Building a Protective Coat
 
Helical Structures
 
Capsids with Icosahedral Symmetry
 
Other Capsid Architectures
 
Packaging the Nucleic Acid Genome
 
Direct Contact of the Genome with a Protein Shell
 
Packaging by Specialized Viral Proteins
 
Packaging by Cellular Proteins
 
Viruses with Envelopes
 
Viral Envelope Components
 
Simple Enveloped Viruses: Direct Contact of External Proteins with the Capsid or Nucleocapsid
 
Enveloped Viruses with an Additional Protein Layer
 
Large Viruses with Multiple
 
Structural Elements Particles with Helical or Icosahedral Parts Alternative Architectures
 
Other Components of Virions
 
Enzymes
 
Other Viral Protei

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Principles of Virology, the leading virology textbook in use, is an extremely valuable and highly informative presentation of virology at the interface of modern cell biology and immunology. This text utilizes a uniquely rational approach by highlighting common principles and processes across all viruses. Using a set of representative viruses to illustrate the breadth of viral complexity, students are able to understand viral reproduction and pathogenesis and are equipped with the necessary tools for future encounters with new or understudied viruses.
 
This fifth edition was updated to keep pace with the ever-changing field of virology. In addition to the beloved full-color illustrations, video interviews with leading scientists, movies, and links to exciting blogposts on relevant topics, this edition includes study questions and active learning puzzles in each chapter, as well as short descriptions regarding the key messages of references of special interest.
 
Volume I: Molecular Biology focuses on the molecular processes of viral reproduction, from entry through release. Volume II: Pathogenesis and Control addresses the interplay between viruses and their host organisms, on both the micro- and macroscale, including chapters on public health, the immune response, vaccines and other antiviral strategies, viral evolution, and a brand new chapter on the therapeutic uses of viruses. These two volumes can be used for separate courses or together in a single course. Each includes a unique appendix, glossary, and links to internet resources.
 
Principles of Virology, Fifth Edition, is ideal for teaching the strategies by which all viruses reproduce, spread within a host, and are maintained within populations. This edition carefully reflects the results of extensive vetting and feedback received from course instructors and students, making this renowned textbook even more appropriate for undergraduate and graduate courses in virology, microbiology, and infectious diseases.