The field of oral microbiology has seen fundamental conceptual changes in recent years. Microbial communities are now seen as the fundamental etiological agent in oral diseases through their interface with host inflammatory responses. Study of structured microbial communities has increased our understanding of the roles of each member in the pathogenesis of oral diseases, principles that apply to both periodontitis and dental caries. Against this backdrop, the third edition of Oral Microbiology and Immunology has been substantially expanded and rewritten by an international team of authors and editors. Featured in the current edition are: links between oral infections and systemic disease revised and updated overview of the role of the immune system in oral infections thorough discussions of biofilm development and control more extensive illustrations and Key Points for student understanding Graduate students, researchers, and clinicians as well as students will find this new edition valuable in study and practice. The field of oral microbiology has seen fundamental conceptual changes in recent years. Microbial communities are now seen as the fundamental etiological agent in oral diseases through their interface with host inflammatory responses. Study of structured microbial communities has increased our understanding of the roles of each member in the pathogenesis of oral diseases, principles that apply to both periodontitis and dental caries.

The field of oral microbiology has seen fundamental conceptual changes in recent years. Microbial communities are now seen as the fundamental etiological agent in oral diseases through their interface with host inflammatory responses. Study of structured microbial communities has increased our understanding of the roles of each member in the pathogenesis of oral diseases, principles that apply to both periodontitis and dental caries.Against this backdrop, the third edition of Oral Microbiology and Immunology has been substantially expanded and rewritten by an international team of authors and editors. Featured in the current edition are:* links between oral infections and systemic disease* revised and updated overview of the role of the immune system in oral infections* thorough discussions of biofilm development and control* more extensive illustrations and Key Points for student understandingGraduate students, researchers, and clinicians as well as students will find this new edition valuable in study and practice. The field of oral microbiology has seen fundamental conceptual changes in recent years. Microbial communities are now seen as the fundamental etiological agent in oral diseases through their interface with host inflammatory responses. Study of structured microbial communities has increased our understanding of the roles of each member in the pathogenesis of oral diseases, principles that apply to both periodontitis and dental caries.

Contributors xxiPreface xxvAbout the Editors xxviiSection I General Principles of Oral Microbiology and Immunology 11 General Microbiology 3Howard F. JenkinsonKey points 282 The Immune System and Its Functions 29George Hajishengallis and Jonathan M. KorostoffKey points 50Further Reading 513 The Oral Environment 53Frank A. Scannapieco and Stefan RuhlKey points 80Further Reading 804 Isolation, Classification, and Identification of Oral Bacteria 81Eugene J. Leys, Ann L. Griffen, and Clifford BeallKey points 99Further Reading 995 Oral Microbial Ecology 101Howard F. Jenkinson and Richard J. LamontKey points 121Further Reading 1226 Oral Microbial Physiology 123Paul G. Egland and Robert E. MarquisKey points 147Further Reading 1477 Genetics and Molecular Biology of Oral Microorganisms 149Angela H. Nobbs, Bing-Yan Wang, and Gena D. TribbleKey points 187Further Reading 1888 Applied Molecular Biology and the Oral Microbes 189Hansel M. Fletcher, Arunima Mishra, Sasanka Chukkapalli, Stuart Dashper, and Ann Progulske-FoxKey points 211Further Reading 2129 Population Genetics of Oral Bacteria 213Mogens KilianKey points 225Further Reading 22610 Immunology of the Oral Cavity 227Evlambia Hajishengallis and George HajishengallisKey points 248Further Reading 248Section II Infection-Driven Oral Diseases 24911 Dental Caries: Etiology and Pathogenesis 251William H. Bowen, Livia M. A. Tenuta, Hyun Koo, and Jaime A. CuryKey points 265Further Reading 26512 Pathogenic Mechanisms in Dental Caries 267José A. Lemos, Hui Wu, Robert G. Quivey, Jr., and Hyun KooKey points 284Further Reading 28513 Periodontal Diseases: General Concepts 287Panos N. PapapanouKey points 307Further Reading 30714 Virulence Factors of Periodontal Bacteria 309Richard J. Lamont, Janina P. Lewis, and Jan Potempa15 Immunopathogenic Mechanisms in Periodontal Disease 333George HajishengallisKey points 356Further Reading 35716 Oral Virology 359Matti SällbergKey points 395Further Reading 39617. Fungi and Fungal Infections of the Oral Cavity 397Richard D. Cannon, Ann R. Holmes, and Norman A. FirthKey points 414Further Reading 41518 Endodontic Infections and Therapeutic Approaches 417Brenda P. F. A. Gomes, Isabela N. Rôças, and José F. Siqueira, Jr.Further Reading 43219 Systemic Disease and the Oral Microbiota 433Angela H. Nobbs and Mark C. HerzbergSection III Control of Oral Diseases 45520 Antibiotics: Mechanisms of Action, Resistance, and Clinical Use in Dentistry 457Pin-Chuang Lai, Hyun Koo, Paul Stoodley, and John WaltersKey points 494Further Reading 49421 Therapeutic Approaches for Biofilm Control and Host Modulation in Oral Diseases 495Yijin Ren, Henry C. van der Mei, George Hajishengallis, Hyun Koo, and Henk J. BusscherKey points 522Further Reading 52222 Infection Prevention and Control in Dentistry 525J. Christopher Fenno, Stephen J. Stefanac, and Brandonn K. PerryKey points 549Further Reading 550Index 551