An exploration of the raw power of genetic material to refashion itself to any purpose Virtually all organisms contain multiple mobile DNAs that can move from place to place, and in some organisms, mobile DNA elements make up a significant portion of the genome. Mobile DNA III provides a comprehensive review of recent research, including findings suggesting the important role that mobile elements play in genome evolution and stability. Editor-in-Chief Nancy L. Craig assembled a team of multidisciplinary experts to develop this cutting-edge resource that covers the specific molecular mechanisms involved in recombination, including a detailed structural analysis of the enzymes responsible presents a detailed account of the many different recombination systems that can rearrange genomes examines the tremendous impact of mobile DNA in virtually all organisms Mobile DNA III is valuable as an in-depth supplemental reading for upper level life sciences students and as a reference for investigators exploring new biological systems. Biomedical researchers will find documentation of recent advances in understanding immune-antigen conflict between host and pathogen. It introduces biotechnicians to amazing tools for in vivo control of designer DNAs. It allows specialists to pick and choose advanced reviews of specific elements and to be drawn in by unexpected parallels and contrasts among the elements in diverse organisms. Mobile DNA III provides the most lucid reviews of these complex topics available anywhere.

An exploration of the raw power of genetic material to refashion itself to any purpose...Virtually all organisms contain multiple mobile DNAs that can move from place to place, and in some organisms, mobile DNA elements make up a significant portion of the genome. Mobile DNA III provides a comprehensive review of recent research, including findings suggesting the important role that mobile elements play in genome evolution and stability.Editor-in-Chief Nancy L. Craig assembled a team of multidisciplinary experts to develop this cutting-edge resource that* covers the specific molecular mechanisms involved in recombination, including a detailed structural analysis of the enzymes responsible* presents a detailed account of the many different recombination systems that can rearrange genomes* examines the tremendous impact of mobile DNA in virtually all organismsMobile DNA III is valuable as an in-depth supplemental reading for upper level life sciences students and as a reference for investigators exploring new biological systems. Biomedical researchers will find documentation of recent advances in understanding immune-antigen conflict between host and pathogen. It introduces biotechnicians to amazing tools for in vivo control of designer DNAs. It allows specialists to pick and choose advanced reviews of specific elements and to be drawn in by unexpected parallels and contrasts among the elements in diverse organisms.Mobile DNA III provides the most lucid reviews of these complex topics available anywhere.

I. Introduction1. A Moveable Feast: An Introduction to Mobile DNAII. Conservative Site-Specific Recombination2. An Overview of Tyrosine Site-specific Recombination: From an Flp Perspective3. The Serine Recombinases4. The lambda Integrase Site-specific Recombination Pathway5. Cre Recombinase6. The Integron: Adaptation On Demand7. Xer Site-Specific Recombination: Promoting Vertical and Horizontal Transmission of Genetic Information8. The Integration and Excision of CTnDOT9. Site-specific DNA Inversion by Serine Recombinases10. Serine Resolvases11. Phage-encoded Serine Integrases and Other Large Serine Recombinases12. Hairpin Telomere Resolvases13. Biology of Three ICE Families: SXT/R391, ICEBs1, and ICESt1/ICESt3III. Programmed Rearrangements14. V(D)J Recombination: Mechanism, Errors, and Fidelity15. Related Mechanisms of Antibody Somatic Hypermutation and Class Switch Recombination16. Programmed Genome Rearrangements in Tetrahymena17. Programmed Rearrangement in Ciliates: Paramecium18. Programmed Genome Rearrangements in the Ciliate Oxytricha19. DNA Recombination Strategies During Antigenic Variation in the African Trypanosome20. Recombination and Diversification of the Variant Antigen Encoding Genes in the Malaria Parasite Plasmodium falciparum21. Mobile DNA in the Pathogenic Neisseria22. vls Antigenic Variation Systems of Lyme Disease Borrelia: Eluding Host Immunity through both Random, Segmental Gene Conversion and Framework Heterogeneity23. Mating-type Gene Switching in Saccharomyces cerevisiae24. A Unique DNA Recombination Mechanism of the Mating/Cell-type Switching of Fission Yeasts: a ReviewIV. Dna-Only Transposons25. Mechanisms of DNA Transposition26. Everyman's Guide to Bacterial Insertion Sequences27. Copy-out-Paste-in Transposition of IS911: A Major Transposition Pathway28. The IS200/IS605 Family and "Peel and Paste" Single-strand Transposition Mechanism29. Transposons Tn10 and Tn530. Tn731. Transposable Phage Mu32. The Tn3-family of Replicative Transposons33. P Transposable Elements in Drosophila and other Eukaryotic Organisms34. Mariner and the ITm Superfamily of TransposonsV. LTR Retrotransposons35. hAT Transposable Elements36. Mutator and MULE Transposons37. Adeno-associated Virus as a Mammalian DNA Vector38. Sleeping Beauty Transposition39. piggyBac Transposon40. Helitrons, the Eukaryotic Rolling-circle Transposable Elements41. Ty1 LTR-retrotransposon of Budding Yeast, Saccharomyces cerevisiae42. Ty3, a Position-specific Retrotransposon in Budding Yeast43. The Long Terminal Repeat Retrotransposons Tf1 and Tf2 of Schizosaccharomyces pombe44. Retroviral Integrase Structure and DNA Recombination Mechanism45. Host Factors in Retroviral Integration and Selection of Integration Target Sites46. Reverse Transcription of Retroviruses and LTR Retrotransposons47. Mammalian Endogenous Retroviruses48. Retroviral DNA Transposition: Themes and VariationsVI. Non-LTR Retrotransposons49. Integration, Regulation, and Long-Term Stability of R2 Retrotransposons50. Site-Specific non-LTR retrotransponsons51. The Influence of LINE-1 and SINE Retrotransposons on Mammalian Genomes52. Mobile Bacterial Group II Introns at the Crux of Eukaryotic Evolution53. Diversity-generating Retroelements in Phage and Bacterial Genomes54. An Unexplored Diversity of Reverse Transcriptases in Bacteria55. Tyrosine Recombinase Retrotransposons and TransposonsIndex