This is an original work dedicated to an important and current topic in nephrology: organ crosstalk in acute renal injury.

Acute kidney injury is a prevalent and serious syndrome. The related mortality to this syndrome has not been significantly reduced in the last decades despite the advances in renal replacement therapy technology. For this reason, a new approach to obtain an effective treatment is urgently needed. The organ crosstalk perspective could be useful in order to achieve this objective since it implies a very early acute kidney injury diagnose and treatment.

This book includes a comprehensive review of the organ crosstalk perspective in acute kidney injury. Organized in two parts, the chapters in the first part present general subjects as an introduction to analysing the crosstalk concept. These chapters give an overview of the concepts of biosemiotics, hormones, neurotransmitters, cytokines, signalling and adhesion molecules, organ intercommunication, and epigenetics. The second part gathers chapters on the different kidney crosstalk, such as brain, lung, heart, liver, gut, and placenta. Finally, there is a chapter dedicated to the influence of renal replacement treatment on kidney crosstalk.

Since acute kidney injury is a topic of interest to many health professionals, this work will be a useful resource to general practitioners, internal medicine physicians, geriatricians, nephrologists, critical care therapists, immunologists, and also biologists and bioengineers.

Part I

Chapter 1: Nosology and Semiotics

Chapter 2: Acute kidney injury: definition and generalities  

Chapter 3: Hormones

Chapter 4: Neurotransmitters and autonomous nervous system

Chapter 5: Cytokines, chemokines, inflammasomes, myokines and complement-related factors in acute kidney injury (AKI)

Chapter 6: Genetic, epigenetics, and cell adhesion in acute kidney injury

Chapter 7: Organs Crosstalk Perspective

Chapter 8: Kidney-Brain Crosstalk in Acute Kidney Injury

Chapter 9: KIDNEY - LUNG CROSSTALK in Acute Kindey Injury

Chapter 10: Kidney-Heart Crosstalk in Acute Kidney Injury

Chapter 11: KIDNEY-GUT CROSS-TALK IN ACUTE KIDNEY INJURY

Chapter 12: Kidney-Liver Crosstalk in Acute Kidney Injury

Chapter 13: Kidney-Muscle cross-talk in acute kidney injury

Chapter 14: Kidney-Placenta Crosstalk in Acute Kidney Injury

Chapter 15: Renal Replacement Treatment, blood purification and Crosstalk in Acute Kidney Injury

Chapter 16: Acute kidney injury and organ crosstalk in COVID-19