"e;Digital Transformation in Healthcare 5.0: IoT, AI, and Digital Twin"e; provides a comprehensive overview of the integration of cutting-edge technology with healthcare, from the Fourth Industrial Revolution (4IR) to the introduction of IoT, AI, and Digital Twin technologies. This in-depth discussion of the digital revolution expanding the healthcare industry covers a wide range of topics, including digital disruption in healthcare delivery, the impact of 4IR and Health 4.0, e-health services and applications, virtual reality's impact on accessible healthcare delivery, digital twins and dietary health technologies, big data analytics in healthcare systems, machine learning models for cost-effective healthcare delivery systems, affordable healthcare with machine learning, enhanced biomedical signal processing with machine learning, and data-driven AI for information retrieval of biomedical images.