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Long Non-coding RNAs in Human Disease
ISBN-13:
9783319239071
Veröffentl:
2016
Einband:
eBook
Seiten:
262
Autor:
Kevin V. Morris
Serie:
394, Current Topics in Microbiology and Immunology
eBook Typ:
PDF
eBook Format:
Reflowable eBook
Kopierschutz:
Digital Watermark [Social-DRM]
Sprache:
Englisch
Beschreibung:
Thisvolume focuses on the roles of long non-coding RNAs (lncRNAs) in contextsranging from human cancers to cardiovascular disease and ageing. The role oflncRNAs in X-inactivation and those lncRNAs derived from pseudogenes, pastretroelements integrated within the human genome, as well as the role thesepseudogene-derived lncRNAs play in cancer development are discussed in detail. Further,the book examines the function of lncRNAs in diseases such as diabetes, in smoothmuscle formation, and in the modulation of nuclear receptors, as well as inconnection with perspectiveson the development ofpersonalized therapeutics. It offers an appealing and insightful resource forscientists and clinicians alike.
This volume focuses on the roles of long non-coding RNAs (lncRNAs) in contexts ranging from human cancers to cardiovascular disease and ageing. The role of lncRNAs in X-inactivation and those lncRNAs derived from pseudogenes, past retroelements integrated within the human genome, as well as the role these pseudogene-derived lncRNAs play in cancer development are discussed in detail. Further, the book examines the function of lncRNAs in diseases such as diabetes, in smooth muscle formation, and in the modulation of nuclear receptors, as well as in connection with perspectives on the development of personalized therapeutics. It offers an appealing and insightful resource for scientists and clinicians alike.
Understanding the Complex Circuitry of lncRNAs at the X-inactivation Center and its Implications in Disease Conditions.- Long Non-coding RNA ANRIL and Polycomb in Human Cancers and Cardiovascular Disease.- Form and function of exosome associated long non-coding RNAs in cancer.- Long Non-coding RNAs in Lung Cancer.- Pseudogene-expressed RNAs: Emerging roles in gene regulation and disease.- Functional long non-coding RNAs in vascular smooth muscle cells.- Long Non-coding RNAs as Targets and Regulators of Nuclear Hormone Receptors.- Non-coding transcriptional landscape in human aging.- LncRNAs in stress response.- Expression Specificity of Disease-Associated lncRNAs: towards Personalized Medicine.