Pediatric Inflammatory Bowel Disease

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2512 g
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285x212x38 mm
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Petar Mamula, MD Associate Professor of Pediatrics, The Children's Hospital of Philadelphia, Division of GI, Hepatology & Nutrition, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA Andrew B. Grossman, MDCo-Director, Center for Pediatric Inflammatory Bowel Disease, The Children's Hospital of Philadelphia, Division of GI, Hepatology & Nutrition , Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USARobert N. Baldassano, MD Director, Center for Pediatric Inflammatory Bowel Disease, The Children's Hospital of Philadelphia, Division of GI, Hepatology & Nutrition, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA< USAJudith R. Kelsen, MD The Children's Hospital of Philadelphia, Division of GI, Hepatology & Nutrition, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USAJonathan E. Markowitz, MD, MSCE Clinical Professor of Pediatrics, University of South Carolina School of Medicine - Greenville Chief, Division of Pediatric Gastroenterology & Nutrition, Greenville Health System, Greenville, SC, USA
Includes updated and new chapters regarding pathogenesis, clinic features, and management of IBD

Section I Etiology and Pathogenesis


1 Genetics of Inflammatory Bowel Diseases

Christopher J. Cardinale, Hakon Hakonarson


2 The Intestinal Immune System During Homeostasis and Inflammatory Bowel Disease

David A. Hill, William A. Faubion Jr.


3 Cytokines and Inflammatory Bowel Disease

Edwin F. de Zoeten, Ivan J. Fuss


4 The Gut Microbiota and Inflammatory Bowel Disease

Máire A. Conrad, Gary D. Wu, Judith R. Kelsen


5 Immune Dysregulation Associated with Very Early-Onset Inflammatory Bowel Disease

Judith Kelsen, Kathleen Sullivan



Section II Epidemiology and Clinical Features


6 Epidemiology of Pediatric Inflammatory Bowel Disease

Shehzad Saeed, Subra Kugathasan


7 The Natural History of Crohn Disease in Children

Benjamin Sahn, James Markowitz


8 Natural History of Ulcerative Colitis in Children

Peter Townsend, Jeffrey S. Hyams


9 Natural History of Pediatric Indeterminate Colitis

Melissa A. Fernandes, Sofia Verstraete, Melvin B. Heyman


10 Extraintestinal Manifestations of Pediatric Inflammatory Bowel Disease

Shervin Rabizadeh, Maria Oliva-Hemker


11 Liver Disease in Pediatric Inflammatory Bowel Disease

Amanda Ricciuto, Binita M. Kamath


12 Growth Impairment in Pediatric Inflammatory Bowel Disease

Thomas D. Walters, Anne M. Griffiths


13 Inflammatory Bowel Diseases and Skeletal Health

Francisco Sylvester


14 Puberty and Pediatric-Onset Inflammatory Bowel Disease

Dianne Deplewski, Neera Gupta, Barbara S. Kirschner


15 Classification of Inflammatory Bowel Disease in Children

Mary E. Sherlock, Eric I. Benchimol



Section III Diagnosis


16 The History and Physical Exam

Alka Goyal


17 Differential Diagnosis of Inflammatory Bowel Disease

Thierry Lamireau, Raphael Enaud


18 Laboratory Evaulation of Inflammatory Bowel Disease

Jennifer Strople, Benjamin D. Gold


19 Fecal Biomarkers in Inflammatory Bowel Disease

Jennifer Damman, KT Park


20 Radiologic Evaulation of Pediatric Inflammatory Bowel Disease

Stephen M. Druhan, Benedict C. Nwomeh


21 Endoscopy and Inflammatory Bowel Disease

Shishu Sharma, Krishnappa Venkatesh, Mike Thomson


22 The Pathology of Chronic Inflammatory Bowel Disease

Pierre Russo


23 Video Capsule Endoscopy in Inflammatory Bowel Disease

Ernest G. Seidman, Che Yung Chao, Ana Maria Sant'Anna


24 Bone Health in Pediatric Inflammatory Bowel Disease

Dale Lee, Edisio Semeao



Section IV Medical Therapy


25 5-Aminosalicylate Therapy

Michael Stephens, Michelle Gonzalez


26 Antibiotic Therapy

Lindsey Albenberg, Howard Kader, Adam Paul


27 Nutritional Management of Inflammatory Bowel Disease

Anthony Otley, Andrew Day, Mary Zachos


28 Probiotic Therapy

David R. Mack


29 Corticosteroids

Charles M. Samson, Johanna C. Escher


30 6-Mercaptopurpine Therapy

Carmen Cuffari


31 Methotrexate

Joel R. Rosh


32 Infliximab Therapy for Pediatric Crohn Disease and Ulcerative Colitis

Philip Minar, Dana Dykes, Ana Catalina Arce-Clachar, Shehzad A. Saeed


33 Anti-TNF Biologic Therapies Other Than Infliximab

Calen A. Steiner, Emily P. Whitfield, Jeremy Adler, Peter D.R. Higgins


34 Therapeutic Drug Monitoring in Pediatric Inflammatory Bowel Disease

Namita Singh, Marla C. Dubinsky


35 New Non-anti-TNF Therapies for the Treatment of Inflammatory Bowel Disease


36 Medical Treatment of Perianal Crohn's Disease Fistulae

Mark T. Osterman, Gary R. Lichtenstein


37 Treatment of Acute Severe Ulcerative Colitis

Jess L. Kaplan, Harland S. Winter


38 Dietary Therapies for Inflammatory Bowel Disease

Ronen Stein, Robert N. Baldassano


39 Complementary and Alternative Therapies

Jennifer Panganiban, Jessi Erlichman, Maria Mascarenhas



Section V Surgical Considerations


40 Management of Intraabdominal Complications of Inflammatory Bowel Disease

Elizabeth C. Maxwell, Peter Mattei, Andrew B. Grossman


41 Surgical Management of Crohn Disease in Children

Daniel von Allmen


42 Surgical Treatment of Ulcerative Colitis

Peter Mattei


43 Postoperative Surveillance and Management of Crohn's Disease

Arthur M. Barrie III, Miguel Regueiro


44 Pouchitis After Ileal Pouch-Anal Anastomosis

Jacob Kurowski, Marsha Kay, Robert Wyllie


45 Enteral Feeding Devices and Ostomies

Judith J. Stellar



Section VI Research


46 Clinical Indices for Pediatric Inflammatory Bowel Disease Research

Dan Turner, Oren Ledder


47 Clinical Trials (Clinical Perspective)

Salvatore Cucchiara, Marina Aloi


48 Clinical Trials (Industry/Regulatory Perspective)

Tara Altepeter, Kurt Brown, Peterson Johnson, Andrew E. Mulberg



Section VII Special Considerations


49 Infectious Complications of Pediatric Inflammatory Bowel Disease

Monica I. Ardura, Sandra C. Kim


50 Psychological Aspects of Inflammatory Bowel Disease in Children and Adolescents

Bonney Reed-Knight, Laura M. Mackner, Wallace V. Crandall


51 Measurement of Quality of Life in Pediatric Inflammatory BOwel Disease

Amy Grant, Anthony Otley


52 Irritable Bowel Syndrome and Functional GI Disorders in Inflammatory Bowel Disease

Khalil I El-Chammas, Manu R. Sood


53 Inflammatory Bowel Disease in Pregnancy

Sunanda Kane


54 Immunizations in the Child with Inflammatory Bowel Disease

Athos Bousvaros, Ying Lu


55 Malignant Tumors Arising in Inflammatory Bowel Disease

Thomas A. Ullman, Rona Yaeger


56 Quality Improvement in Inflammatory Bowel Disease

Jeremy Adler, Richard B. Colletti, Wallace V. Crandall, Peter A. Margolis


57 Fostering Self-Management and Patient Activation

David Alain Wohl, Justin Vandergrift


58 Advocacy for Pediatric Patients with Inflammatory Bowel Disease

Janis Arnold, Athos Bousvaros


59 Legislative Advocacy

Sarah Buchanan, Suzanne Rosenthal


60 Transition from Pediatric to Adult Care

Stacy A. Kahn, Sandra C. Kim

The latest edition of this essential text provides a comprehensive overview of the unique pediatric issues of inflammatory bowel disease. Through new and thoroughly revised chapters, the volume features updates regarding pathogenesis, clinic features, and management, with an emphasis on recent understanding of pharmacokinetics and the utilization of cutting edge therapeutic monitoring to maximize efficacy of medical management. The new edition also highlights newer, recently approved drugs, emerging therapies, and the most recent recommendations regarding post-operative management for patients who ultimately require surgery.

Written by experts in the field, Pediatric Inflammatory Bowel Disease, Third Edition is a valuable resource for both pediatric and adult gastroenterologists involved in the care of children with inflammatory bowel disease.

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