This book gives a comprehensive overview about medicinal inorganic chemistry. Topics like targeting strategies, mechanism of action, Pt-based antitumor drugs, radiopharmaceuticals are covered in detail and offer the reader an in-depth overview about this important topic.

Edited by a renowned and experienced lecturer, this handbook and reference provides an in-depth overview of this key area in medicine and bioinorganic chemistry, detailing such topics as targeting strategies, mechanism of action, Pt-based antitumor drugs and radiopharmaceuticals.

MEDICINAL INORGANIC CHEMISTRY: STATE OF THE ART, NEW TRENDS, AND A VISION OF THE FUTUREIntroductionAntimicrobial AgentsAntiviral AgentsSystemic and Metabolic Diseases Including InflammationMetal Chelating AgentsAntiarthritic Drugs and InflammationBipolar DisorderAnticancer AgentsSmall Molecule Delivery and ControlDiagnostic AgentsVeterinary Medicinal Inorganic ChemistryConclusions and VisionTARGETING STRATEGIES FOR METAL-BASED THERAPEUTICSIntroductionPhysiological TargetingMolecular TargetingImmunological TargetingConcluding RemarksCURRENT STATUS AND MECHANISM OF ACTION OF PLATINUM-BASED ANTICANCER DRUGSIntroductionMechanism of Action of CisplatinLimitations of Current Platinum-Based Compounds: New StrategiesNovel Concepts in the Development of Platinum Antitumor DrugsConcluding RemarksNEW TRENDS AND FUTURE DEVELOPMENTS OF PLATINUM-BASED ANTITUMOR DRUGSIntroductionMechanisms of Action and ResistanceMonofunctional Platinum(II) ComplexesTrans-Platinum(II) ComplexesMultinuclear Platinum(II) C omplexesPlatinum(IV) ComplexesDelivery of Platinum DrugsConcluding Remarks and Future PerspectivesRUTHENIUM AND OTHER NON-PLATINUM ANTICANCER COMPOUNDSIntroductionRuthenium Anticancer CompoundsFrom Gallium Nitrate to Oral Gallium ComplexesTitanium Anticancer CompoundsFerrocene-Derived Anticancer AgentsThe Main Group Organometallics Spirogermanium and Germanium-132Arsenic in Cancer ChemotherapyOvercoming the Resistance of Tumors to Anticancer Agents by Rare Earth Element CompoundsConclusionsTHE CHALLENGE OF ESTABLISHING RELIABLE SCREENING TESTS FOR SELECTING ANTICANCER METAL COMPOUNDSIntroductionTumor Cell Growth Inhibition and Cell Death Screening AssaysMetal-Based Anticancer Compounds and Gene Expression Microarray TechnologiesMetal-Based Anticancer Compounds and the Proteomic ApproachConcluding RemarksGOLD-BASED THERAPEUTIC AGENTS: A NEW PERSPECTIVEIntroductionBiological Chemistry of GoldGold Antiarthritic DrugsGold Complexes as Anticancer AgentsGold Complexes as Antiparasitic AgentsConcluding RemarksMRI CONTRAST AGENTS: STATE OF THE ART AND NEW TRENDSIntroductionT1 AgentsT2-Susceptibility AgentsCEST AgentsConcluding RemarksMETAL-BASED RADIOPHARMACEUTICALSIntroductionSelected Examples: Therapeutic RadiopharmaceuticalsDiagnostic Metal-Based RadiopharmaceuticalsPerspectives and ConclusionBORON AND GADOLINIUM IN THE NEUTRON CAPTURE THERAPY OF CANCERIntroductionBoron Neutron Capture TherapyRole of Medicinal Inorganic Chemistry in BNCTGadolinium Neutron Capture TherapyConclusions and Future OutlookESSENTIAL METAL RELATED METABOLIC DISORDERSIntroduction: What is Essentiality?Iron Metabolic Diseases: Acquired and GeneticCopper Metabolic DiseasesZinc Metabolic DiseasesDiseases Related to Imbalances in Electrolytic Metabolism: P, the Alkali Metals, and the Alkaline EarthsMetabolism of Other Trace ElementsConclusionsMETAL COMPOUNDS AS ENZYME INHIBITORSIntroductionKinase InhibitorsProteasome InhibitorsCarbonic Anhydrase Inhibitors (CAIs)Cyclooxygenase InhibitorsAcetylcholinesterase InhibitorsProtein Phosphatase InhibitorsTrypsin and Thrombin InhibitorsCysteine Protease Inhibitors and Glutathione Transferase InhibitorsHIV-1 Reverse Transcriptase and Protease InhibitorsTelomerase InhibitorsZinc Finger Protein InhibitorsCXCR4 InhibitorsXanthine Oxidase InhibitorsMiscellaneous Protein Inhibitors and ConclusionsBIOMEDICAL APPLICATIONS OF METAL-CONTAINING LUMINOPHORESIntroduction: Luminescence in Diagnostics and ImagingTransition-Metal Containing Luminescent AgentsLanthanide-Based LuminophoresNanoparticle-Based LuninophoresConclusions and Perspectives